Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs
All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well i...
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| Veröffentlicht in: | Journal of general virology 2012-03, Vol.93 (Pt 3), p.603-607 |
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| container_end_page | 607 |
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| container_issue | Pt 3 |
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| container_title | Journal of general virology |
| container_volume | 93 |
| creator | Yoshikawa, Rokusuke Yasuda, Jiro Kobayashi, Takeshi Miyazawa, Takayuki |
| description | All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus. |
| doi_str_mv | 10.1099/vir.0.036228-0 |
| format | Article |
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Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.</description><identifier>ISSN: 1465-2099</identifier><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/vir.0.036228-0</identifier><identifier>PMID: 22131312</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Society for General Microbiology</publisher><subject>Amino Acid Transport System ASC - metabolism ; amino acid transporters ; Animals ; attenuated vaccines ; Biological and medical sciences ; cats ; Cells, Cultured ; Dogs ; Endogenous Retroviruses - physiology ; Fundamental and applied biological sciences. Psychology ; immunosuppression (physiological) ; kidney cells ; Macaca mulatta ; Mason-Pfizer monkey virus ; Mason-Pfizer monkey virus - physiology ; Microbiology ; Miscellaneous ; Receptors, Virus - metabolism ; risk ; vaccines ; Virology ; Virus Attachment ; virus receptors ; viruses</subject><ispartof>Journal of general virology, 2012-03, Vol.93 (Pt 3), p.603-607</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-da978d1be8ba072f3d3272093631ef85ef592b798f852f8a87065c148293276e3</citedby><cites>FETCH-LOGICAL-c454t-da978d1be8ba072f3d3272093631ef85ef592b798f852f8a87065c148293276e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3747,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25544377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22131312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, Rokusuke</creatorcontrib><creatorcontrib>Yasuda, Jiro</creatorcontrib><creatorcontrib>Kobayashi, Takeshi</creatorcontrib><creatorcontrib>Miyazawa, Takayuki</creatorcontrib><title>Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.</description><subject>Amino Acid Transport System ASC - metabolism</subject><subject>amino acid transporters</subject><subject>Animals</subject><subject>attenuated vaccines</subject><subject>Biological and medical sciences</subject><subject>cats</subject><subject>Cells, Cultured</subject><subject>Dogs</subject><subject>Endogenous Retroviruses - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>immunosuppression (physiological)</subject><subject>kidney cells</subject><subject>Macaca mulatta</subject><subject>Mason-Pfizer monkey virus</subject><subject>Mason-Pfizer monkey virus - physiology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Receptors, Virus - metabolism</subject><subject>risk</subject><subject>vaccines</subject><subject>Virology</subject><subject>Virus Attachment</subject><subject>virus receptors</subject><subject>viruses</subject><issn>1465-2099</issn><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0M9LwzAUB_AgitPp1aPmIp5a87Npj6P-mDAQ3HYOaZqMStfMpBX87412_iCH9yAfXvK-AFxglGJUFLfvjU9RimhGSJ6gA3CCWcYTEq8O__UTcBrCK0KYMS6OwYQQTOMhJ2Beqq7pDJwtyxWGqqu_OwKVN9AOne4b16kWeqPNrnc-QOs8fLlLMGYwvj0E2HSwdptwBo6saoM539cpWD_cr8p5snh-fCpni0QzzvqkVoXIa1yZvFJIEEtrSkT8Is0oNjbnxvKCVKLIY09srnKBMq4xy0kRYWboFNyMc3fevQ0m9HLbBG3aVnXGDUEWJC4nSIajTEepvQvBGyt3vtkq_yExkl_hybiARHIML5YpuNyPHqqtqX_5T1oRXO-BClq11qtON-HPcc4YFSK6q9FZ5aTa-GjWS4JwhhAiokCMfgIqpHzK</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Yoshikawa, Rokusuke</creator><creator>Yasuda, Jiro</creator><creator>Kobayashi, Takeshi</creator><creator>Miyazawa, Takayuki</creator><general>Society for General Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs</title><author>Yoshikawa, Rokusuke ; Yasuda, Jiro ; Kobayashi, Takeshi ; Miyazawa, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-da978d1be8ba072f3d3272093631ef85ef592b798f852f8a87065c148293276e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amino Acid Transport System ASC - metabolism</topic><topic>amino acid transporters</topic><topic>Animals</topic><topic>attenuated vaccines</topic><topic>Biological and medical sciences</topic><topic>cats</topic><topic>Cells, Cultured</topic><topic>Dogs</topic><topic>Endogenous Retroviruses - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>immunosuppression (physiological)</topic><topic>kidney cells</topic><topic>Macaca mulatta</topic><topic>Mason-Pfizer monkey virus</topic><topic>Mason-Pfizer monkey virus - physiology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Receptors, Virus - metabolism</topic><topic>risk</topic><topic>vaccines</topic><topic>Virology</topic><topic>Virus Attachment</topic><topic>virus receptors</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, Rokusuke</creatorcontrib><creatorcontrib>Yasuda, Jiro</creatorcontrib><creatorcontrib>Kobayashi, Takeshi</creatorcontrib><creatorcontrib>Miyazawa, Takayuki</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, Rokusuke</au><au>Yasuda, Jiro</au><au>Kobayashi, Takeshi</au><au>Miyazawa, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>93</volume><issue>Pt 3</issue><spage>603</spage><epage>607</epage><pages>603-607</pages><issn>1465-2099</issn><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. 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| subjects | Amino Acid Transport System ASC - metabolism amino acid transporters Animals attenuated vaccines Biological and medical sciences cats Cells, Cultured Dogs Endogenous Retroviruses - physiology Fundamental and applied biological sciences. Psychology immunosuppression (physiological) kidney cells Macaca mulatta Mason-Pfizer monkey virus Mason-Pfizer monkey virus - physiology Microbiology Miscellaneous Receptors, Virus - metabolism risk vaccines Virology Virus Attachment virus receptors viruses |
| title | Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs |
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