Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15
Summary Early T‐cell precursor acute lymphoblastic leukaemia (ETP‐ALL) is a recently identified subtype of T‐ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers...
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| Veröffentlicht in: | British journal of haematology 2012-02, Vol.156 (3), p.358-365 |
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| creator | Inukai, Takeshi Kiyokawa, Nobutaka Campana, Dario Coustan-Smith, Elaine Kikuchi, Akira Kobayashi, Miyuki Takahashi, Hiroyuki Koh, Katsuyoshi Manabe, Atsushi Kumagai, Masaaki Ikuta, Koichiro Hayashi, Yasuhide Tsuchida, Masahiro Sugita, Kanji Ohara, Akira |
| description | Summary
Early T‐cell precursor acute lymphoblastic leukaemia (ETP‐ALL) is a recently identified subtype of T‐ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT‐ALL using a previously classified cohort. Then, we applied the cell marker profile that best discriminated ETP‐ALL to a cohort of 91 patients with T‐ALL enrolled in the Tokyo Children’s Cancer Study Group L99‐15 study, which included allogeneic stem cell transplantation (allo‐SCT) for patients with poor prednisone response. Five of the 91 patients (5·5%) met the ETP‐ALL criteria. There were no significant differences in presenting clinical features between these and the remaining 86 patients. Response to early remission induction therapy was inferior in ETP‐ALL as compared with T‐ALL. The ETP‐ALL subgroup showed a significantly poorer event‐free survival (4‐year rate; 40%) than the T‐ALL subgroup (70%, P = 0·014). Of note, three of four relapsed ETP‐ALL patients survived after allo‐SCT, indicating that allo‐SCT can be effective for this drug‐resistant subtype of T‐ALL. |
| doi_str_mv | 10.1111/j.1365-2141.2011.08955.x |
| format | Article |
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Early T‐cell precursor acute lymphoblastic leukaemia (ETP‐ALL) is a recently identified subtype of T‐ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT‐ALL using a previously classified cohort. Then, we applied the cell marker profile that best discriminated ETP‐ALL to a cohort of 91 patients with T‐ALL enrolled in the Tokyo Children’s Cancer Study Group L99‐15 study, which included allogeneic stem cell transplantation (allo‐SCT) for patients with poor prednisone response. Five of the 91 patients (5·5%) met the ETP‐ALL criteria. There were no significant differences in presenting clinical features between these and the remaining 86 patients. Response to early remission induction therapy was inferior in ETP‐ALL as compared with T‐ALL. The ETP‐ALL subgroup showed a significantly poorer event‐free survival (4‐year rate; 40%) than the T‐ALL subgroup (70%, P = 0·014). Of note, three of four relapsed ETP‐ALL patients survived after allo‐SCT, indicating that allo‐SCT can be effective for this drug‐resistant subtype of T‐ALL.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2011.08955.x</identifier><identifier>PMID: 22128890</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>acute lymphoblastic leukaemia ; Adolescent ; allogeneic stem cell transplantation ; Antigens, CD - analysis ; Antigens, Neoplasm - analysis ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; cell marker profile ; Child ; Child, Preschool ; childhood ; Combined Modality Therapy ; Disease-Free Survival ; Drug Resistance, Neoplasm ; Early T-cell precursor ; Female ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Infant ; Japan - epidemiology ; Kaplan-Meier Estimate ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - surgery ; Prednisone - administration & dosage ; Remission Induction ; Stem Cell Transplantation ; Transplantation, Homologous ; Treatment Outcome</subject><ispartof>British journal of haematology, 2012-02, Vol.156 (3), p.358-365</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5195-510e169f2ebade3e5abf1b0d9ad04e00860babbe1600b7919f422f3bb51b612d3</citedby><cites>FETCH-LOGICAL-c5195-510e169f2ebade3e5abf1b0d9ad04e00860babbe1600b7919f422f3bb51b612d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2011.08955.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2011.08955.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25564832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22128890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inukai, Takeshi</creatorcontrib><creatorcontrib>Kiyokawa, Nobutaka</creatorcontrib><creatorcontrib>Campana, Dario</creatorcontrib><creatorcontrib>Coustan-Smith, Elaine</creatorcontrib><creatorcontrib>Kikuchi, Akira</creatorcontrib><creatorcontrib>Kobayashi, Miyuki</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Koh, Katsuyoshi</creatorcontrib><creatorcontrib>Manabe, Atsushi</creatorcontrib><creatorcontrib>Kumagai, Masaaki</creatorcontrib><creatorcontrib>Ikuta, Koichiro</creatorcontrib><creatorcontrib>Hayashi, Yasuhide</creatorcontrib><creatorcontrib>Tsuchida, Masahiro</creatorcontrib><creatorcontrib>Sugita, Kanji</creatorcontrib><creatorcontrib>Ohara, Akira</creatorcontrib><title>Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Early T‐cell precursor acute lymphoblastic leukaemia (ETP‐ALL) is a recently identified subtype of T‐ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT‐ALL using a previously classified cohort. Then, we applied the cell marker profile that best discriminated ETP‐ALL to a cohort of 91 patients with T‐ALL enrolled in the Tokyo Children’s Cancer Study Group L99‐15 study, which included allogeneic stem cell transplantation (allo‐SCT) for patients with poor prednisone response. Five of the 91 patients (5·5%) met the ETP‐ALL criteria. There were no significant differences in presenting clinical features between these and the remaining 86 patients. Response to early remission induction therapy was inferior in ETP‐ALL as compared with T‐ALL. The ETP‐ALL subgroup showed a significantly poorer event‐free survival (4‐year rate; 40%) than the T‐ALL subgroup (70%, P = 0·014). Of note, three of four relapsed ETP‐ALL patients survived after allo‐SCT, indicating that allo‐SCT can be effective for this drug‐resistant subtype of T‐ALL.</description><subject>acute lymphoblastic leukaemia</subject><subject>Adolescent</subject><subject>allogeneic stem cell transplantation</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>cell marker profile</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>childhood</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Drug Resistance, Neoplasm</subject><subject>Early T-cell precursor</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Japan - epidemiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - surgery</subject><subject>Prednisone - administration & dosage</subject><subject>Remission Induction</subject><subject>Stem Cell Transplantation</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAQhiMEYsvCKyBf0HJJGDtx4iBxWCLosipw2CIQF8tOJtSt2xQ7Ec1L8Mw4tJQbwheP5O8fj_1FEaGQ0LBerBOa5jxmNKMJA0oTECXnyeFeNDsf3I9mAFDEFDJxET3yfg1AU-D0YXTBGGVClDCLflbW7EytLPHm2860odzVSLqWoHJ2JMu4RmvJ3mE9ON85ouqhR2LH7X7Vaat8b2picdgo3Br1kjj0g-391KBfIVl2m7Ej1crYxuHuypNqau_IXT80I5m7btif6kVZxpQ_jh60ynp8ctovo09v3yyrm3jxcf6uul7ENacljzkFpHnZMtSqwRS50i3V0JSqgQwBRA5aaR0YAF2UtGwzxtpUa051TlmTXkZXx757130f0Pdya_z0UrXDbvCyZLRgHDIWyOf_JCkwEJkQaR5QcURr13nvsJV7Z7bKjQGSkze5lpMeOemRkzf525s8hOjT0y2D3mJzDv4RFYBnJ0D5YKt14R-N_8txnmcincZ9deR-GIvjfw8gX9_eTFXIx8e88T0eznnlNjIv0oLLzx_mkt-K4uv7L0Lepb8ATZHDLg</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Inukai, Takeshi</creator><creator>Kiyokawa, Nobutaka</creator><creator>Campana, Dario</creator><creator>Coustan-Smith, Elaine</creator><creator>Kikuchi, Akira</creator><creator>Kobayashi, Miyuki</creator><creator>Takahashi, Hiroyuki</creator><creator>Koh, Katsuyoshi</creator><creator>Manabe, Atsushi</creator><creator>Kumagai, Masaaki</creator><creator>Ikuta, Koichiro</creator><creator>Hayashi, Yasuhide</creator><creator>Tsuchida, Masahiro</creator><creator>Sugita, Kanji</creator><creator>Ohara, Akira</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15</title><author>Inukai, Takeshi ; Kiyokawa, Nobutaka ; Campana, Dario ; Coustan-Smith, Elaine ; Kikuchi, Akira ; Kobayashi, Miyuki ; Takahashi, Hiroyuki ; Koh, Katsuyoshi ; Manabe, Atsushi ; Kumagai, Masaaki ; Ikuta, Koichiro ; Hayashi, Yasuhide ; Tsuchida, Masahiro ; Sugita, Kanji ; Ohara, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5195-510e169f2ebade3e5abf1b0d9ad04e00860babbe1600b7919f422f3bb51b612d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>acute lymphoblastic leukaemia</topic><topic>Adolescent</topic><topic>allogeneic stem cell transplantation</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>cell marker profile</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>childhood</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Drug Resistance, Neoplasm</topic><topic>Early T-cell precursor</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Infant</topic><topic>Japan - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - surgery</topic><topic>Prednisone - administration & dosage</topic><topic>Remission Induction</topic><topic>Stem Cell Transplantation</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inukai, Takeshi</creatorcontrib><creatorcontrib>Kiyokawa, Nobutaka</creatorcontrib><creatorcontrib>Campana, Dario</creatorcontrib><creatorcontrib>Coustan-Smith, Elaine</creatorcontrib><creatorcontrib>Kikuchi, Akira</creatorcontrib><creatorcontrib>Kobayashi, Miyuki</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Koh, Katsuyoshi</creatorcontrib><creatorcontrib>Manabe, Atsushi</creatorcontrib><creatorcontrib>Kumagai, Masaaki</creatorcontrib><creatorcontrib>Ikuta, Koichiro</creatorcontrib><creatorcontrib>Hayashi, Yasuhide</creatorcontrib><creatorcontrib>Tsuchida, Masahiro</creatorcontrib><creatorcontrib>Sugita, Kanji</creatorcontrib><creatorcontrib>Ohara, Akira</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inukai, Takeshi</au><au>Kiyokawa, Nobutaka</au><au>Campana, Dario</au><au>Coustan-Smith, Elaine</au><au>Kikuchi, Akira</au><au>Kobayashi, Miyuki</au><au>Takahashi, Hiroyuki</au><au>Koh, Katsuyoshi</au><au>Manabe, Atsushi</au><au>Kumagai, Masaaki</au><au>Ikuta, Koichiro</au><au>Hayashi, Yasuhide</au><au>Tsuchida, Masahiro</au><au>Sugita, Kanji</au><au>Ohara, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>156</volume><issue>3</issue><spage>358</spage><epage>365</epage><pages>358-365</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Early T‐cell precursor acute lymphoblastic leukaemia (ETP‐ALL) is a recently identified subtype of T‐ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT‐ALL using a previously classified cohort. Then, we applied the cell marker profile that best discriminated ETP‐ALL to a cohort of 91 patients with T‐ALL enrolled in the Tokyo Children’s Cancer Study Group L99‐15 study, which included allogeneic stem cell transplantation (allo‐SCT) for patients with poor prednisone response. Five of the 91 patients (5·5%) met the ETP‐ALL criteria. There were no significant differences in presenting clinical features between these and the remaining 86 patients. Response to early remission induction therapy was inferior in ETP‐ALL as compared with T‐ALL. The ETP‐ALL subgroup showed a significantly poorer event‐free survival (4‐year rate; 40%) than the T‐ALL subgroup (70%, P = 0·014). Of note, three of four relapsed ETP‐ALL patients survived after allo‐SCT, indicating that allo‐SCT can be effective for this drug‐resistant subtype of T‐ALL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22128890</pmid><doi>10.1111/j.1365-2141.2011.08955.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 2012-02, Vol.156 (3), p.358-365 |
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| subjects | acute lymphoblastic leukaemia Adolescent allogeneic stem cell transplantation Antigens, CD - analysis Antigens, Neoplasm - analysis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences cell marker profile Child Child, Preschool childhood Combined Modality Therapy Disease-Free Survival Drug Resistance, Neoplasm Early T-cell precursor Female Hematologic and hematopoietic diseases Humans Immunophenotyping Infant Japan - epidemiology Kaplan-Meier Estimate Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - surgery Prednisone - administration & dosage Remission Induction Stem Cell Transplantation Transplantation, Homologous Treatment Outcome |
| title | Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15 |
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