Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4

► This is the first report to clarify how FRP acts in immunity on a molecular level. ► FRP associates with CD14 on the cell surface and triggers TLR4 signaling. ► FRP is considered to be a DAMP, because FRP is one of the endogenous TLR4 agonists. ► Similar to LPS, FRP can induce tolerance to TLR4 si...

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Veröffentlicht in:	FEBS letters 2012-02, Vol.586 (4), p.319-324
Hauptverfasser:	Murakami, Kosaku, Tanaka, Masao, Usui, Takashi, Kawabata, Daisuke, Shiomi, Aoi, Iguchi-Hashimoto, Mikiko, Shimizu, Masakazu, Yukawa, Naoichiro, Yoshifuji, Hajime, Nojima, Takaki, Ohmura, Koichiro, Fujii, Takao, Umehara, Hisanori, Mimori, Tsuneyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-type II collagen antibody-induced arthritis CAIA CD14 CIA collagen-induced arthritis damage-associated molecular patterns DAMPs DIP2A disco-interacting protein 2 homolog A from Drosophila follistatin-like 1 follistatin-related protein Follistatin-Related Proteins - antagonists & inhibitors Follistatin-Related Proteins - genetics Follistatin-Related Proteins - immunology Follistatin-Related Proteins - pharmacology FRP FSTL1 Gene Knockdown Techniques HEK293 Cells high-mobility group box1 HMGB1 Humans IL-6 IL-8 Immunity, Innate Innate immunity interleukin 6 interleukin 8 Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis lipopolysaccharide Lipopolysaccharide Receptors - metabolism LPS matrix metalloproteinases Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout MMPs/Mmps MRP-8/14 myeloid-related protein-8/14 NIH 3T3 Cells PAMPs pathogen-associated molecular patterns PMB Polymixin B Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - pharmacology Rheumatoid arthritis Rhodobacter sphaeroides LPS RS-LPS Signal Transduction TGF-β TLR4 toll-like receptor 4 Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism transforming growth factor β
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