Evolutionary engineering of Saccharomyces cerevisiae for improved industrially important properties
Abstract This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the ‘rational’ metabolic engineering approach and its limitations such as extensive genetic and metabolic information requirement on the organism of interest, complexity of cellular...
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| Veröffentlicht in: | FEMS yeast research 2012-03, Vol.12 (2), p.171-182 |
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| creator | Cakar, Z Petek Turanli-Yildiz, Burcu Alkim, Ceren Yilmaz, Ulkü |
| description | Abstract
This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the ‘rational’ metabolic engineering approach and its limitations such as extensive genetic and metabolic information requirement on the organism of interest, complexity of cellular physiological responses, and difficulties of cloning in industrial strains, evolutionary engineering is discussed as an alternative, inverse metabolic engineering strategy. Major evolutionary engineering applications with S. cerevisiae are then discussed in two general categories: (1) evolutionary engineering of substrate utilization and product formation and (2) evolutionary engineering of stress resistance. Recent developments in functional genomics methods allow rapid identification of the molecular basis of the desired phenotypes obtained by evolutionary engineering. To conclude, when used alone or in combination with rational metabolic engineering and/or computational methods to study and analyze processes of adaptive evolution, evolutionary engineering is a powerful strategy for improvement in industrially important, complex properties of S. cerevisiae. |
| doi_str_mv | 10.1111/j.1567-1364.2011.00775.x |
| format | Article |
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This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the ‘rational’ metabolic engineering approach and its limitations such as extensive genetic and metabolic information requirement on the organism of interest, complexity of cellular physiological responses, and difficulties of cloning in industrial strains, evolutionary engineering is discussed as an alternative, inverse metabolic engineering strategy. Major evolutionary engineering applications with S. cerevisiae are then discussed in two general categories: (1) evolutionary engineering of substrate utilization and product formation and (2) evolutionary engineering of stress resistance. Recent developments in functional genomics methods allow rapid identification of the molecular basis of the desired phenotypes obtained by evolutionary engineering. To conclude, when used alone or in combination with rational metabolic engineering and/or computational methods to study and analyze processes of adaptive evolution, evolutionary engineering is a powerful strategy for improvement in industrially important, complex properties of S. cerevisiae.</description><identifier>ISSN: 1567-1356</identifier><identifier>EISSN: 1567-1364</identifier><identifier>DOI: 10.1111/j.1567-1364.2011.00775.x</identifier><identifier>PMID: 22136139</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>arabinose fermentation ; Biological Evolution ; Computer applications ; Engineering ; Evolution ; Evolution & development ; evolutionary engineering ; Genomics ; Industrial Microbiology ; Industrial strains ; Metabolic engineering ; Metabolic Engineering - methods ; Metabolism ; Phenotype ; Phenotypes ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; stress resistance ; xylose fermentation ; Yeast</subject><ispartof>FEMS yeast research, 2012-03, Vol.12 (2), p.171-182</ispartof><rights>2012 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. 2012</rights><rights>2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved</rights><rights>2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.</rights><rights>2012 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5555-fbbbc0c2c3880bc1c46834b30d14e6ef827d67f5d7aa434a98928f0ee5a6350e3</citedby><cites>FETCH-LOGICAL-c5555-fbbbc0c2c3880bc1c46834b30d14e6ef827d67f5d7aa434a98928f0ee5a6350e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1567-1364.2011.00775.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1567-1364.2011.00775.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27904,27905,45554,45555</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22136139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nielsen, Jens</contributor><creatorcontrib>Cakar, Z Petek</creatorcontrib><creatorcontrib>Turanli-Yildiz, Burcu</creatorcontrib><creatorcontrib>Alkim, Ceren</creatorcontrib><creatorcontrib>Yilmaz, Ulkü</creatorcontrib><title>Evolutionary engineering of Saccharomyces cerevisiae for improved industrially important properties</title><title>FEMS yeast research</title><addtitle>FEMS Yeast Res</addtitle><description>Abstract
This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the ‘rational’ metabolic engineering approach and its limitations such as extensive genetic and metabolic information requirement on the organism of interest, complexity of cellular physiological responses, and difficulties of cloning in industrial strains, evolutionary engineering is discussed as an alternative, inverse metabolic engineering strategy. Major evolutionary engineering applications with S. cerevisiae are then discussed in two general categories: (1) evolutionary engineering of substrate utilization and product formation and (2) evolutionary engineering of stress resistance. Recent developments in functional genomics methods allow rapid identification of the molecular basis of the desired phenotypes obtained by evolutionary engineering. To conclude, when used alone or in combination with rational metabolic engineering and/or computational methods to study and analyze processes of adaptive evolution, evolutionary engineering is a powerful strategy for improvement in industrially important, complex properties of S. cerevisiae.</description><subject>arabinose fermentation</subject><subject>Biological Evolution</subject><subject>Computer applications</subject><subject>Engineering</subject><subject>Evolution</subject><subject>Evolution & development</subject><subject>evolutionary engineering</subject><subject>Genomics</subject><subject>Industrial Microbiology</subject><subject>Industrial strains</subject><subject>Metabolic engineering</subject><subject>Metabolic Engineering - methods</subject><subject>Metabolism</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>stress resistance</subject><subject>xylose fermentation</subject><subject>Yeast</subject><issn>1567-1356</issn><issn>1567-1364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUU1P3DAQtVARu2z7F5ClHnpK8FfiROqlWkFBQkICeujJcpzJ4lUSb-1ky_57HBb2UITUucxo5r2Z0XsIYUpSGuN8ndIslwnluUgZoTQlRMosfTpC88Pg06HO8hk6DWFNCJWEFCdoxlhEUF7OkbnYunYcrOu132HoV7YH8LZfYdfge23Mo_au2xkI2ICHrQ1WA26cx7bbeLeFGtu-HsPgrW7b3dR1ftD9gON0A36wED6j40a3Ab685gX6dXnxsLxKbm5_Xi9_3CQmi5E0VVUZYpjhRUEqQ43ICy4qTmoqIIemYLLOZZPVUmvBhS6LkhUNAch0zjMCfIG-7ffG039GCIPqbDDQtroHNwZVsihIKSmLyK__INdu9H18TjHOhRRMxLxAxR5lvAvBQ6M23nZRJ0WJmnxQazVJrCa51eSDevFBPUXq2euBseqgPhDfhI-A73vAX9vC7r8Xq8vfd7GIdL6nu3HzATl5_9UzSounTg</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Cakar, Z Petek</creator><creator>Turanli-Yildiz, Burcu</creator><creator>Alkim, Ceren</creator><creator>Yilmaz, Ulkü</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Evolutionary engineering of Saccharomyces cerevisiae for improved industrially important properties</title><author>Cakar, Z Petek ; 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This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the ‘rational’ metabolic engineering approach and its limitations such as extensive genetic and metabolic information requirement on the organism of interest, complexity of cellular physiological responses, and difficulties of cloning in industrial strains, evolutionary engineering is discussed as an alternative, inverse metabolic engineering strategy. Major evolutionary engineering applications with S. cerevisiae are then discussed in two general categories: (1) evolutionary engineering of substrate utilization and product formation and (2) evolutionary engineering of stress resistance. Recent developments in functional genomics methods allow rapid identification of the molecular basis of the desired phenotypes obtained by evolutionary engineering. To conclude, when used alone or in combination with rational metabolic engineering and/or computational methods to study and analyze processes of adaptive evolution, evolutionary engineering is a powerful strategy for improvement in industrially important, complex properties of S. cerevisiae.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22136139</pmid><doi>10.1111/j.1567-1364.2011.00775.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | arabinose fermentation Biological Evolution Computer applications Engineering Evolution Evolution & development evolutionary engineering Genomics Industrial Microbiology Industrial strains Metabolic engineering Metabolic Engineering - methods Metabolism Phenotype Phenotypes Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism stress resistance xylose fermentation Yeast |
| title | Evolutionary engineering of Saccharomyces cerevisiae for improved industrially important properties |
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