Ileal bladder augmentation and vitamin B12: Levels decrease with time after surgery
Abstract Objective We investigated vitamin B12 deficiency following ileocystoplasty in children. Methods Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were c...
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| Veröffentlicht in: | Journal of pediatric urology 2012-02, Vol.8 (1), p.47-50 |
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| creator | Blackburn, S.C Parkar, S Prime, M Healiss, L Desai, D Mustaq, I Cuckow, P Duffy, P Cherian, A |
| description | Abstract Objective We investigated vitamin B12 deficiency following ileocystoplasty in children. Methods Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were considered deficient. The distance of the ileal segment from the ileocaecal valve was recorded. Results There were 105 patients in the series; 61 were male. Mean age at surgery was 7.7 years (SD = 3.9). The mean interval from surgery to most recent B12 level was 50 months (SD = 30). None of the patients were on B12 supplementation. Two patients were B12 deficient, both more than 7 years after surgery; 44% of patients with levels available 7 years after surgery had a B12 below 300 pg/ml. There was a significant negative correlation between B12 level and length of follow up (Spearman’s rank, P |
| doi_str_mv | 10.1016/j.jpurol.2010.11.007 |
| format | Article |
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Methods Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were considered deficient. The distance of the ileal segment from the ileocaecal valve was recorded. Results There were 105 patients in the series; 61 were male. Mean age at surgery was 7.7 years (SD = 3.9). The mean interval from surgery to most recent B12 level was 50 months (SD = 30). None of the patients were on B12 supplementation. Two patients were B12 deficient, both more than 7 years after surgery; 44% of patients with levels available 7 years after surgery had a B12 below 300 pg/ml. There was a significant negative correlation between B12 level and length of follow up (Spearman’s rank, P < 0.01). Twenty patients with an ileal segment sparing 60 cm from the ileocaecal valve had a higher mean B12 (524 vs 419, SEM 60 vs 28). This was not statistically significant. Conclusion We demonstrate a reduction in serum B12 level with time following ileocystoplasty. These patients should have their B12 levels measured in the long term.</description><identifier>ISSN: 1477-5131</identifier><identifier>EISSN: 1873-4898</identifier><identifier>DOI: 10.1016/j.jpurol.2010.11.007</identifier><identifier>PMID: 21183408</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age Distribution ; Anastomosis, Surgical ; B12 ; Bladder augmentation ; Child ; Child, Preschool ; Cohort Studies ; Enterocystoplasty ; Female ; Follow-Up Studies ; Humans ; Ileocystoplasty ; Ileum - surgery ; Incidence ; Male ; Pediatric ; Pediatrics ; Postoperative Care - methods ; Reconstructive Surgical Procedures - adverse effects ; Reconstructive Surgical Procedures - methods ; Retrospective Studies ; Risk Assessment ; Sex Distribution ; Time Factors ; Treatment Outcome ; Urinary Bladder - abnormalities ; Urinary Bladder - surgery ; Urology ; Vitamin B 12 - blood ; Vitamin B 12 Deficiency - epidemiology ; Vitamin B 12 Deficiency - etiology ; Vitamin B 12 Deficiency - physiopathology</subject><ispartof>Journal of pediatric urology, 2012-02, Vol.8 (1), p.47-50</ispartof><rights>Journal of Pediatric Urology Company</rights><rights>2010 Journal of Pediatric Urology Company</rights><rights>Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-1345582f8d032dc88aa3eff442354536590dfb8ce00bc01e5962f4818b8366953</citedby><cites>FETCH-LOGICAL-c416t-1345582f8d032dc88aa3eff442354536590dfb8ce00bc01e5962f4818b8366953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpurol.2010.11.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21183408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blackburn, S.C</creatorcontrib><creatorcontrib>Parkar, S</creatorcontrib><creatorcontrib>Prime, M</creatorcontrib><creatorcontrib>Healiss, L</creatorcontrib><creatorcontrib>Desai, D</creatorcontrib><creatorcontrib>Mustaq, I</creatorcontrib><creatorcontrib>Cuckow, P</creatorcontrib><creatorcontrib>Duffy, P</creatorcontrib><creatorcontrib>Cherian, A</creatorcontrib><title>Ileal bladder augmentation and vitamin B12: Levels decrease with time after surgery</title><title>Journal of pediatric urology</title><addtitle>J Pediatr Urol</addtitle><description>Abstract Objective We investigated vitamin B12 deficiency following ileocystoplasty in children. Methods Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were considered deficient. The distance of the ileal segment from the ileocaecal valve was recorded. Results There were 105 patients in the series; 61 were male. Mean age at surgery was 7.7 years (SD = 3.9). The mean interval from surgery to most recent B12 level was 50 months (SD = 30). None of the patients were on B12 supplementation. Two patients were B12 deficient, both more than 7 years after surgery; 44% of patients with levels available 7 years after surgery had a B12 below 300 pg/ml. There was a significant negative correlation between B12 level and length of follow up (Spearman’s rank, P < 0.01). Twenty patients with an ileal segment sparing 60 cm from the ileocaecal valve had a higher mean B12 (524 vs 419, SEM 60 vs 28). This was not statistically significant. Conclusion We demonstrate a reduction in serum B12 level with time following ileocystoplasty. These patients should have their B12 levels measured in the long term.</description><subject>Age Distribution</subject><subject>Anastomosis, Surgical</subject><subject>B12</subject><subject>Bladder augmentation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Enterocystoplasty</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Ileocystoplasty</subject><subject>Ileum - surgery</subject><subject>Incidence</subject><subject>Male</subject><subject>Pediatric</subject><subject>Pediatrics</subject><subject>Postoperative Care - methods</subject><subject>Reconstructive Surgical Procedures - adverse effects</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urinary Bladder - abnormalities</subject><subject>Urinary Bladder - surgery</subject><subject>Urology</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>Vitamin B 12 Deficiency - etiology</subject><subject>Vitamin B 12 Deficiency - physiopathology</subject><issn>1477-5131</issn><issn>1873-4898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxSMEoqXwDRDyjVOWGdtJHA5ItOJPpZU4FM6WY0-Kg5MstrNovz2JtnDgwmlGo_feSL9XFC8RdghYvxl2w2GJc9hx2E64A2geFZeoGlFK1arH6y6bpqxQ4EXxLKUBQDTA26fFBUdUQoK6LO5uA5nAumCco8jMcj_SlE3288TM5NjRZzP6iV0jf8v2dKSQmCMbySRiv3z-zrIfiZk-r-60xHuKp-fFk96ERC8e5lXx7eOHrzefy_2XT7c37_ellVjnEoWsKsV75UBwZ5UyRlDfS8lFJStRVy24vlOWADoLSFVb814qVJ0Sdd1W4qp4fc49xPnnQinr0SdLIZiJ5iXplqPkiiu1KuVZaeOcUqReH6IfTTxpBL3R1IM-09QbTY2oV5qr7dXDg6Ubyf01_cG3Ct6dBSsWOnqKOllPkyXnI9ms3ez_9-HfABv85K0JP-hEaZiXOK0INerENei7rdGtUAQA2baN-A0smZt5</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Blackburn, S.C</creator><creator>Parkar, S</creator><creator>Prime, M</creator><creator>Healiss, L</creator><creator>Desai, D</creator><creator>Mustaq, I</creator><creator>Cuckow, P</creator><creator>Duffy, P</creator><creator>Cherian, A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Ileal bladder augmentation and vitamin B12: Levels decrease with time after surgery</title><author>Blackburn, S.C ; Parkar, S ; Prime, M ; Healiss, L ; Desai, D ; Mustaq, I ; Cuckow, P ; Duffy, P ; Cherian, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-1345582f8d032dc88aa3eff442354536590dfb8ce00bc01e5962f4818b8366953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Distribution</topic><topic>Anastomosis, Surgical</topic><topic>B12</topic><topic>Bladder augmentation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Enterocystoplasty</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Ileocystoplasty</topic><topic>Ileum - surgery</topic><topic>Incidence</topic><topic>Male</topic><topic>Pediatric</topic><topic>Pediatrics</topic><topic>Postoperative Care - methods</topic><topic>Reconstructive Surgical Procedures - adverse effects</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Urinary Bladder - abnormalities</topic><topic>Urinary Bladder - surgery</topic><topic>Urology</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>Vitamin B 12 Deficiency - etiology</topic><topic>Vitamin B 12 Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blackburn, S.C</creatorcontrib><creatorcontrib>Parkar, S</creatorcontrib><creatorcontrib>Prime, M</creatorcontrib><creatorcontrib>Healiss, L</creatorcontrib><creatorcontrib>Desai, D</creatorcontrib><creatorcontrib>Mustaq, I</creatorcontrib><creatorcontrib>Cuckow, P</creatorcontrib><creatorcontrib>Duffy, P</creatorcontrib><creatorcontrib>Cherian, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blackburn, S.C</au><au>Parkar, S</au><au>Prime, M</au><au>Healiss, L</au><au>Desai, D</au><au>Mustaq, I</au><au>Cuckow, P</au><au>Duffy, P</au><au>Cherian, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ileal bladder augmentation and vitamin B12: Levels decrease with time after surgery</atitle><jtitle>Journal of pediatric urology</jtitle><addtitle>J Pediatr Urol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>8</volume><issue>1</issue><spage>47</spage><epage>50</epage><pages>47-50</pages><issn>1477-5131</issn><eissn>1873-4898</eissn><abstract>Abstract Objective We investigated vitamin B12 deficiency following ileocystoplasty in children. Methods Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were considered deficient. The distance of the ileal segment from the ileocaecal valve was recorded. Results There were 105 patients in the series; 61 were male. Mean age at surgery was 7.7 years (SD = 3.9). The mean interval from surgery to most recent B12 level was 50 months (SD = 30). None of the patients were on B12 supplementation. Two patients were B12 deficient, both more than 7 years after surgery; 44% of patients with levels available 7 years after surgery had a B12 below 300 pg/ml. There was a significant negative correlation between B12 level and length of follow up (Spearman’s rank, P < 0.01). Twenty patients with an ileal segment sparing 60 cm from the ileocaecal valve had a higher mean B12 (524 vs 419, SEM 60 vs 28). This was not statistically significant. Conclusion We demonstrate a reduction in serum B12 level with time following ileocystoplasty. These patients should have their B12 levels measured in the long term.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21183408</pmid><doi>10.1016/j.jpurol.2010.11.007</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Distribution Anastomosis, Surgical B12 Bladder augmentation Child Child, Preschool Cohort Studies Enterocystoplasty Female Follow-Up Studies Humans Ileocystoplasty Ileum - surgery Incidence Male Pediatric Pediatrics Postoperative Care - methods Reconstructive Surgical Procedures - adverse effects Reconstructive Surgical Procedures - methods Retrospective Studies Risk Assessment Sex Distribution Time Factors Treatment Outcome Urinary Bladder - abnormalities Urinary Bladder - surgery Urology Vitamin B 12 - blood Vitamin B 12 Deficiency - epidemiology Vitamin B 12 Deficiency - etiology Vitamin B 12 Deficiency - physiopathology |
| title | Ileal bladder augmentation and vitamin B12: Levels decrease with time after surgery |
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