Growth hormone receptor (ghr) RNAi decreases proliferation and enhances apoptosis in CMT‐U27 canine mammary carcinoma cell line

Canine mammary gland has been identified as a major site of the extrapituitary growth hormone (GH) production. This finding is linked to its role in tumourigenesis of the mammary gland. Our previous studies indicated the role of GH and GH receptor (GHR) in regulation of proliferation and apoptosis....

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Veröffentlicht in:	Veterinary & comparative oncology 2012-03, Vol.10 (1), p.2-15
Hauptverfasser:	Pawłowski, K. M, Popielarz, D, Szyszko, K, Gajewska, M, Motyl, T, Król, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Apoptosis canine mammary cancer carcinoma cell communication cell cycle Cell Line, Tumor cell viability Databases, Nucleic Acid death Dog Diseases - metabolism Dog Diseases - pathology Dogs Female gene silencing growth hormone growth hormone receptor Immunohistochemistry - veterinary mammary glands Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology Mammary Neoplasms, Experimental - metabolism Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism RNA Interference siRNA somatotropin somatotropin receptors
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