CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome

Women classified as having triple-negative tumors have a poor prognosis. The importance of CD44(+)/CD24(-/low) (stem/progenitor cell-phenotype) in breast cancer patients has also been appreciated. However, correlation between triple negativity and CD44(+)/CD24(-/low) with tumor recurrence remains el...

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Veröffentlicht in:	Human pathology 2012-03, Vol.43 (3), p.364-373
Hauptverfasser:	Idowu, Michael O, Kmieciak, Maciej, Dumur, Catherine, Burton, Regina S, Grimes, Margaret M, Powers, Celeste N, Manjili, Masoud H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biomarkers, Tumor - metabolism Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism CD24 Antigen - genetics CD24 Antigen - metabolism Cell Line, Tumor Disease Models, Animal Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Mice Mice, Transgenic Middle Aged Neoplasm Staging Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oligonucleotide Array Sequence Analysis Receptor, ErbB-2 - metabolism Receptors, Steroid - metabolism
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