Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules
Background Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. To our knowledge, no data are available about the prevalence of thyroid nodules in female obese patients. The aim of this study was to investigate the prevalence of thyroid n...
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| Veröffentlicht in: | Obesity surgery 2012-03, Vol.22 (3), p.460-464 |
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| creator | Cappelli, Carlo Pirola, Ilenia Mittempergher, Francesco De Martino, Elvira Casella, Claudio Agosti, Barbara Nascimbeni, Riccardo Formenti, Annamaria Rosei, Enrico Agabiti Castellano, Maurizio |
| description | Background
Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. To our knowledge, no data are available about the prevalence of thyroid nodules in female obese patients. The aim of this study was to investigate the prevalence of thyroid nodules in morbidly obese women.
Methods
One hundred eight consecutive female obese patients were selected from those referred to our medical and surgery outpatients providing that following criteria were satisfied: (1) affected by morbid obesity (body mass index (BMI) >40 kg/m
2
); (2) no previous diagnosis of thyroid disease; (3) biochemically proven euthyroid state at the time of recruitment. Ninety-seven control subjects, constituted by normo-weight and/or slightly overweight (BMI ≤ 30 kg/m
2
) women, should satisfy the above criteria 2 and 3. All the subjects were submitted to ultrasound investigation.
Results
The two groups of patients displayed no differences for age and fT4 levels. Obese patients clearly showed a lower prevalence of thyroid nodules [odds ratio 0.294, 95% confidence interval 0.206–0.382]. A single nodule was found in 23% of obese patients as compared to 65% of control subjects (
p
|
| doi_str_mv | 10.1007/s11695-011-0410-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_921423305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>921423305</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-fe5cea499ce5748f969625df06800fa0e330aeb7d0818c8004e1e955709e21793</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_gBcJXjytzmQ_cyzFL6jWQ8VjSHdndct2U5Ndpf_elK0KgqcwyTPvZB7GThEuESC9coiJjANADCBCCOI9NsQUMl-JbJ8NQSYQZFKEA3bk3BJAYCLEIRsIjCRiGA7Z44Oxi6rgswW5qt3wquEvZkUNrxwfO2fySrdU8NZwzafmkyx_svSha2py4qbk87eNNb7_0RRdTe6YHZS6dnSyO0fs-eZ6PrkLprPb-8l4GuRhCm1QUpyTjqTMKU6jrJSJTERclJBkAKUGCkPQtEgLyDDL_V1ESDKOU5AkMJXhiF30uWtr3jtyrVpVLqe61g2ZzinpNxQ-JPbk-R9yaTrb-M95CKRMQ5l5CHsot8Y5S6Va22ql7UYhqK1q1atWXrXaqlbb4LNdcLdYUfHT8e3WA6IHnH9qXsn-Tv4_9QuIv4bh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>920997398</pqid></control><display><type>article</type><title>Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Cappelli, Carlo ; Pirola, Ilenia ; Mittempergher, Francesco ; De Martino, Elvira ; Casella, Claudio ; Agosti, Barbara ; Nascimbeni, Riccardo ; Formenti, Annamaria ; Rosei, Enrico Agabiti ; Castellano, Maurizio</creator><creatorcontrib>Cappelli, Carlo ; Pirola, Ilenia ; Mittempergher, Francesco ; De Martino, Elvira ; Casella, Claudio ; Agosti, Barbara ; Nascimbeni, Riccardo ; Formenti, Annamaria ; Rosei, Enrico Agabiti ; Castellano, Maurizio</creatorcontrib><description>Background
Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. To our knowledge, no data are available about the prevalence of thyroid nodules in female obese patients. The aim of this study was to investigate the prevalence of thyroid nodules in morbidly obese women.
Methods
One hundred eight consecutive female obese patients were selected from those referred to our medical and surgery outpatients providing that following criteria were satisfied: (1) affected by morbid obesity (body mass index (BMI) >40 kg/m
2
); (2) no previous diagnosis of thyroid disease; (3) biochemically proven euthyroid state at the time of recruitment. Ninety-seven control subjects, constituted by normo-weight and/or slightly overweight (BMI ≤ 30 kg/m
2
) women, should satisfy the above criteria 2 and 3. All the subjects were submitted to ultrasound investigation.
Results
The two groups of patients displayed no differences for age and fT4 levels. Obese patients clearly showed a lower prevalence of thyroid nodules [odds ratio 0.294, 95% confidence interval 0.206–0.382]. A single nodule was found in 23% of obese patients as compared to 65% of control subjects (
p
< 0.0001). No difference for age (year) was found between obese and non-obese subjects with nodules (40.5 ± 8.2 vs. 44.2 ± 8.9, respectively,
p
= 0.07).
Conclusions
Our data clearly show a significantly lower prevalence of thyroid nodules in morbidly obese patients. Further studies are needed to confirm and to understand this first observation.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-011-0410-5</identifier><identifier>PMID: 21491133</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Body Mass Index ; Case-Control Studies ; Clinical Research ; Female ; Humans ; Italy - epidemiology ; Medicine ; Medicine & Public Health ; Obesity ; Obesity, Morbid - diagnostic imaging ; Obesity, Morbid - epidemiology ; Obesity, Morbid - metabolism ; Prevalence ; Risk Assessment ; Risk Factors ; Surgery ; Thyroid diseases ; Thyroid Nodule - diagnostic imaging ; Thyroid Nodule - epidemiology ; Thyroid Nodule - metabolism ; Thyrotropin - metabolism ; Ultrasonography ; Women</subject><ispartof>Obesity surgery, 2012-03, Vol.22 (3), p.460-464</ispartof><rights>Springer Science + Business Media, LLC 2011</rights><rights>Springer Science + Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-fe5cea499ce5748f969625df06800fa0e330aeb7d0818c8004e1e955709e21793</citedby><cites>FETCH-LOGICAL-c370t-fe5cea499ce5748f969625df06800fa0e330aeb7d0818c8004e1e955709e21793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-011-0410-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-011-0410-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21491133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cappelli, Carlo</creatorcontrib><creatorcontrib>Pirola, Ilenia</creatorcontrib><creatorcontrib>Mittempergher, Francesco</creatorcontrib><creatorcontrib>De Martino, Elvira</creatorcontrib><creatorcontrib>Casella, Claudio</creatorcontrib><creatorcontrib>Agosti, Barbara</creatorcontrib><creatorcontrib>Nascimbeni, Riccardo</creatorcontrib><creatorcontrib>Formenti, Annamaria</creatorcontrib><creatorcontrib>Rosei, Enrico Agabiti</creatorcontrib><creatorcontrib>Castellano, Maurizio</creatorcontrib><title>Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. To our knowledge, no data are available about the prevalence of thyroid nodules in female obese patients. The aim of this study was to investigate the prevalence of thyroid nodules in morbidly obese women.
Methods
One hundred eight consecutive female obese patients were selected from those referred to our medical and surgery outpatients providing that following criteria were satisfied: (1) affected by morbid obesity (body mass index (BMI) >40 kg/m
2
); (2) no previous diagnosis of thyroid disease; (3) biochemically proven euthyroid state at the time of recruitment. Ninety-seven control subjects, constituted by normo-weight and/or slightly overweight (BMI ≤ 30 kg/m
2
) women, should satisfy the above criteria 2 and 3. All the subjects were submitted to ultrasound investigation.
Results
The two groups of patients displayed no differences for age and fT4 levels. Obese patients clearly showed a lower prevalence of thyroid nodules [odds ratio 0.294, 95% confidence interval 0.206–0.382]. A single nodule was found in 23% of obese patients as compared to 65% of control subjects (
p
< 0.0001). No difference for age (year) was found between obese and non-obese subjects with nodules (40.5 ± 8.2 vs. 44.2 ± 8.9, respectively,
p
= 0.07).
Conclusions
Our data clearly show a significantly lower prevalence of thyroid nodules in morbidly obese patients. Further studies are needed to confirm and to understand this first observation.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Clinical Research</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Obesity, Morbid - diagnostic imaging</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Obesity, Morbid - metabolism</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Thyroid diseases</subject><subject>Thyroid Nodule - diagnostic imaging</subject><subject>Thyroid Nodule - epidemiology</subject><subject>Thyroid Nodule - metabolism</subject><subject>Thyrotropin - metabolism</subject><subject>Ultrasonography</subject><subject>Women</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBcJXjytzmQ_cyzFL6jWQ8VjSHdndct2U5Ndpf_elK0KgqcwyTPvZB7GThEuESC9coiJjANADCBCCOI9NsQUMl-JbJ8NQSYQZFKEA3bk3BJAYCLEIRsIjCRiGA7Z44Oxi6rgswW5qt3wquEvZkUNrxwfO2fySrdU8NZwzafmkyx_svSha2py4qbk87eNNb7_0RRdTe6YHZS6dnSyO0fs-eZ6PrkLprPb-8l4GuRhCm1QUpyTjqTMKU6jrJSJTERclJBkAKUGCkPQtEgLyDDL_V1ESDKOU5AkMJXhiF30uWtr3jtyrVpVLqe61g2ZzinpNxQ-JPbk-R9yaTrb-M95CKRMQ5l5CHsot8Y5S6Va22ql7UYhqK1q1atWXrXaqlbb4LNdcLdYUfHT8e3WA6IHnH9qXsn-Tv4_9QuIv4bh</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Cappelli, Carlo</creator><creator>Pirola, Ilenia</creator><creator>Mittempergher, Francesco</creator><creator>De Martino, Elvira</creator><creator>Casella, Claudio</creator><creator>Agosti, Barbara</creator><creator>Nascimbeni, Riccardo</creator><creator>Formenti, Annamaria</creator><creator>Rosei, Enrico Agabiti</creator><creator>Castellano, Maurizio</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules</title><author>Cappelli, Carlo ; Pirola, Ilenia ; Mittempergher, Francesco ; De Martino, Elvira ; Casella, Claudio ; Agosti, Barbara ; Nascimbeni, Riccardo ; Formenti, Annamaria ; Rosei, Enrico Agabiti ; Castellano, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-fe5cea499ce5748f969625df06800fa0e330aeb7d0818c8004e1e955709e21793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Clinical Research</topic><topic>Female</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Obesity, Morbid - diagnostic imaging</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Obesity, Morbid - metabolism</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Thyroid diseases</topic><topic>Thyroid Nodule - diagnostic imaging</topic><topic>Thyroid Nodule - epidemiology</topic><topic>Thyroid Nodule - metabolism</topic><topic>Thyrotropin - metabolism</topic><topic>Ultrasonography</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cappelli, Carlo</creatorcontrib><creatorcontrib>Pirola, Ilenia</creatorcontrib><creatorcontrib>Mittempergher, Francesco</creatorcontrib><creatorcontrib>De Martino, Elvira</creatorcontrib><creatorcontrib>Casella, Claudio</creatorcontrib><creatorcontrib>Agosti, Barbara</creatorcontrib><creatorcontrib>Nascimbeni, Riccardo</creatorcontrib><creatorcontrib>Formenti, Annamaria</creatorcontrib><creatorcontrib>Rosei, Enrico Agabiti</creatorcontrib><creatorcontrib>Castellano, Maurizio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cappelli, Carlo</au><au>Pirola, Ilenia</au><au>Mittempergher, Francesco</au><au>De Martino, Elvira</au><au>Casella, Claudio</au><au>Agosti, Barbara</au><au>Nascimbeni, Riccardo</au><au>Formenti, Annamaria</au><au>Rosei, Enrico Agabiti</au><au>Castellano, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>22</volume><issue>3</issue><spage>460</spage><epage>464</epage><pages>460-464</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. To our knowledge, no data are available about the prevalence of thyroid nodules in female obese patients. The aim of this study was to investigate the prevalence of thyroid nodules in morbidly obese women.
Methods
One hundred eight consecutive female obese patients were selected from those referred to our medical and surgery outpatients providing that following criteria were satisfied: (1) affected by morbid obesity (body mass index (BMI) >40 kg/m
2
); (2) no previous diagnosis of thyroid disease; (3) biochemically proven euthyroid state at the time of recruitment. Ninety-seven control subjects, constituted by normo-weight and/or slightly overweight (BMI ≤ 30 kg/m
2
) women, should satisfy the above criteria 2 and 3. All the subjects were submitted to ultrasound investigation.
Results
The two groups of patients displayed no differences for age and fT4 levels. Obese patients clearly showed a lower prevalence of thyroid nodules [odds ratio 0.294, 95% confidence interval 0.206–0.382]. A single nodule was found in 23% of obese patients as compared to 65% of control subjects (
p
< 0.0001). No difference for age (year) was found between obese and non-obese subjects with nodules (40.5 ± 8.2 vs. 44.2 ± 8.9, respectively,
p
= 0.07).
Conclusions
Our data clearly show a significantly lower prevalence of thyroid nodules in morbidly obese patients. Further studies are needed to confirm and to understand this first observation.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21491133</pmid><doi>10.1007/s11695-011-0410-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Obesity surgery, 2012-03, Vol.22 (3), p.460-464 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| subjects | Adult Body Mass Index Case-Control Studies Clinical Research Female Humans Italy - epidemiology Medicine Medicine & Public Health Obesity Obesity, Morbid - diagnostic imaging Obesity, Morbid - epidemiology Obesity, Morbid - metabolism Prevalence Risk Assessment Risk Factors Surgery Thyroid diseases Thyroid Nodule - diagnostic imaging Thyroid Nodule - epidemiology Thyroid Nodule - metabolism Thyrotropin - metabolism Ultrasonography Women |
| title | Morbid Obesity in Women is Associated to a Lower Prevalence of Thyroid Nodules |
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