Simultaneous Quantification of Eleven Thiopurine Nucleotides by Liquid Chromatography-Tandem Mass Spectrometry

The prodrugs azathioprine and 6-mercaptopurine, which are well-established anticancer and immunosuppressive agents, are extensively metabolized by activating and inactivating enzymes. Whereas the 6-thioguanine nucleotides (TGN) are currently being considered as major active metabolites, methylthioin...

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Veröffentlicht in:	Analytical chemistry (Washington) 2012-02, Vol.84 (3), p.1294-1301
Hauptverfasser:	Hofmann, Ute, Heinkele, Georg, Angelberger, Sieglinde, Schaeffeler, Elke, Lichtenberger, Cornelia, Jaeger, Simon, Reinisch, Walter, Schwab, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Azathioprine - analysis Azathioprine - metabolism Azathioprine - therapeutic use Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid Crohn Disease - drug therapy Erythrocytes Erythrocytes - chemistry Erythrocytes - metabolism Exact sciences and technology Guanine Nucleotides - analysis Humans Immunosuppressive Agents - analysis Immunosuppressive Agents - metabolism Immunosuppressive Agents - therapeutic use Isotope Labeling Mass spectrometry Mercaptopurine - analysis Mercaptopurine - metabolism Mercaptopurine - therapeutic use Metabolism Metabolites Methylthioinosine - analysis Other chromatographic methods Spectrometric and optical methods Tandem Mass Spectrometry Thionucleotides - analysis Thionucleotides - metabolism
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