Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors

Inflammatory responses mediated by glial cells play a critical role in many pathological situations related to neurodegeneration such as Alzheimer's disease. Tissue plasminogen activator (tPA) is a serine protease which best‐known function is fibrinolysis, but it is also involved in many other...

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Veröffentlicht in:	Glia 2012-04, Vol.60 (4), p.526-540
Hauptverfasser:	Pineda, David, AmpurdanÉS, Coral, Medina, Manel G., Serratosa, Joan, Tusell, Josep Maria, Saura, Josep, Planas, Anna M., Navarro, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - pharmacology Animals Annexin A2 - metabolism Cells, Cultured Cerebral Cortex - cytology Drug Interactions Enzyme Inhibitors - pharmacology ERK1/2 Galectin 1 - deficiency Galectin 1 - metabolism Gene Knockout Techniques JNK Lipopolysaccharides - pharmacology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics Mice Mice, Inbred C57BL Mice, Knockout microglial activation Mutation - genetics Neuroglia - drug effects Neuroglia - metabolism neuroinflammation Nitric Oxide - metabolism p38 Peptide Fragments - pharmacology Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism RNA, Small Interfering - metabolism Time Factors Tissue Plasminogen Activator - deficiency Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - pharmacology TNFα Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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