Very late initiation of HAART impairs treatment response at 48 and 96 weeks: results from a meta-analysis of randomized clinical trials

Initiation of highly active antiretroviral therapy (HAART) with low CD4 lymphocyte counts is associated with AIDS-related and non-AIDS-related events and increased mortality. However, no clear association has been found with an increased rate of treatment failure. We conducted a meta-analysis includ...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2012-02, Vol.67 (2), p.312-321
Hauptverfasser:	PEREZ-MOLINA, Jose A, DIAZ-MENENDEZ, Marta, PLANA, María N, ZAMORA, Javier, LOPEZ-VELEZ, Rogelio, MORENO, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Anti-HIV Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretroviral Therapy, Highly Active - methods Biological and medical sciences CD4 Lymphocyte Count Clinical trials Coinfection Drug therapy Hepatitis B - complications Hepatitis B virus Hepatitis C - complications Hepatitis C virus HIV Infections - drug therapy HIV Infections - immunology HIV Infections - mortality Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Meta-analysis Mortality Pharmacology. Drug treatments Randomized Controlled Trials as Topic Survival Analysis Time Factors Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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