Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway

Summary Background Previous studies have established that mycobacterial infections ameliorate allergic inflammation. However, a non‐infectious approach that controls allergic responses might represent a safer and more promising strategy. The 60–65 kDa heat shock protein (Hsp) family is endowed with...

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Veröffentlicht in:	Clinical and experimental allergy 2012-01, Vol.42 (1), p.131-143
Hauptverfasser:	Fonseca, D. M., Wowk, P. F., Paula, M. O., Campos, L. W., Gembre, A. F., Turato, W. M., Ramos, S. G., Dias-Baruffi, M., Barboza, R., Gomes, E., Silva, C. L., Russo, M., Bonato, V. L. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway allergic inflammation Allergens Allergic diseases Animal models Animals Antiinflammatory agents Bacterial Proteins - genetics Bacterial Proteins - immunology Biological and medical sciences Chaperonin 60 - genetics Chaperonin 60 - immunology Disease Models, Animal DNA DNA, Recombinant - administration & dosage DNA, Recombinant - immunology Eosinophilia Female Fundamental and applied biological sciences. Psychology Fundamental immunology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism heat shock protein Heat shock proteins Helper cells Hsp65 protein Humans Hypersensitivity Immunoregulation Immunotherapy Immunotherapy - methods Infection Inflammation Interleukin 10 Interleukin-10 - immunology Interleukin-10 - metabolism Leukocyte migration Lung diseases Lymphocytes T Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Mucus Mycobacterium Mycobacterium leprae - immunology Ovalbumin Plasmids recombinant DNA Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - therapy Respiratory tract Treatment Outcome
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