Cytokine levels and profiles in children related to sickle cell disease and asthma status
Atopic asthma in patients with sickle cell disease (SCD) is associated with an increased risk of acute chest syndrome (ACS). Cytokine-mediated inflammation might explain this association. Studies of cytokine profiles in patients with SCD have yielded conflicting data, but the possible influence of a...
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| Veröffentlicht in: | Journal of interferon & cytokine research 2012-01, Vol.32 (1), p.1-5 |
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| creator | Knight-Madden, Jennifer Vergani, Diego Patey, Richard Sylvester, Karl Hussain, Munther J Forrester, Terrence Greenough, Anne |
| description | Atopic asthma in patients with sickle cell disease (SCD) is associated with an increased risk of acute chest syndrome (ACS). Cytokine-mediated inflammation might explain this association. Studies of cytokine profiles in patients with SCD have yielded conflicting data, but the possible influence of asthma status has not been examined. Our aim was to test the hypothesis that cytokine levels and profiles in SCD children reflected their asthma status. Samples from 155 Jamaican children (80 had SCD) and 64 British children (53 had SCD) who had their asthma status documented were analyzed for the presence and levels of interleukin 4 (IL-4) and interferon (IFN)-γ; they were also classified by their T helper cell (Th) cytokine profile. Jamaican children with SCD, when compared with Jamaican controls, were more likely to be diagnosed with asthma (P=0.001), more likely to be IL-4 positive (P |
| doi_str_mv | 10.1089/jir.2011.0030 |
| format | Article |
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Cytokine-mediated inflammation might explain this association. Studies of cytokine profiles in patients with SCD have yielded conflicting data, but the possible influence of asthma status has not been examined. Our aim was to test the hypothesis that cytokine levels and profiles in SCD children reflected their asthma status. Samples from 155 Jamaican children (80 had SCD) and 64 British children (53 had SCD) who had their asthma status documented were analyzed for the presence and levels of interleukin 4 (IL-4) and interferon (IFN)-γ; they were also classified by their T helper cell (Th) cytokine profile. Jamaican children with SCD, when compared with Jamaican controls, were more likely to be diagnosed with asthma (P=0.001), more likely to be IL-4 positive (P<0.001), and more likely to be classified as having a Th-2 pattern (<0.001). In contrast, British children with SCD, when compared with the British controls, were less likely to have been diagnosed with asthma (P=0.04) and less likely to be classified as having a Th-2 pattern (P=0.006). Regression analysis demonstrated that amongst Jamaican children, SCD status, but not asthma status, ACS history, or gender, was predictive of IL-4 positivity and Th-2 status (P<0.001). In British children, none of those variables were significant predictors of IL-4 positivity or Th status. Cytokine profiles differed between Jamaican and British children. In the Jamaican children they reflected SCD, but not asthma or ACS status.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2011.0030</identifier><identifier>PMID: 21916607</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - immunology ; Asthma - blood ; Asthma - complications ; Asthma - immunology ; Child ; Child, Preschool ; Cytokines - blood ; Cytokines - immunology ; Humans ; Th2 Cells - immunology</subject><ispartof>Journal of interferon & cytokine research, 2012-01, Vol.32 (1), p.1-5</ispartof><rights>(©) Copyright 2012, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-89e4482ed8188f43a8424a9ea878f9686e7d471a7b84f89379ddc8d3859e0d973</citedby><cites>FETCH-LOGICAL-c351t-89e4482ed8188f43a8424a9ea878f9686e7d471a7b84f89379ddc8d3859e0d973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21916607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knight-Madden, Jennifer</creatorcontrib><creatorcontrib>Vergani, Diego</creatorcontrib><creatorcontrib>Patey, Richard</creatorcontrib><creatorcontrib>Sylvester, Karl</creatorcontrib><creatorcontrib>Hussain, Munther J</creatorcontrib><creatorcontrib>Forrester, Terrence</creatorcontrib><creatorcontrib>Greenough, Anne</creatorcontrib><title>Cytokine levels and profiles in children related to sickle cell disease and asthma status</title><title>Journal of interferon & cytokine research</title><addtitle>J Interferon Cytokine Res</addtitle><description>Atopic asthma in patients with sickle cell disease (SCD) is associated with an increased risk of acute chest syndrome (ACS). Cytokine-mediated inflammation might explain this association. Studies of cytokine profiles in patients with SCD have yielded conflicting data, but the possible influence of asthma status has not been examined. Our aim was to test the hypothesis that cytokine levels and profiles in SCD children reflected their asthma status. Samples from 155 Jamaican children (80 had SCD) and 64 British children (53 had SCD) who had their asthma status documented were analyzed for the presence and levels of interleukin 4 (IL-4) and interferon (IFN)-γ; they were also classified by their T helper cell (Th) cytokine profile. Jamaican children with SCD, when compared with Jamaican controls, were more likely to be diagnosed with asthma (P=0.001), more likely to be IL-4 positive (P<0.001), and more likely to be classified as having a Th-2 pattern (<0.001). In contrast, British children with SCD, when compared with the British controls, were less likely to have been diagnosed with asthma (P=0.04) and less likely to be classified as having a Th-2 pattern (P=0.006). Regression analysis demonstrated that amongst Jamaican children, SCD status, but not asthma status, ACS history, or gender, was predictive of IL-4 positivity and Th-2 status (P<0.001). In British children, none of those variables were significant predictors of IL-4 positivity or Th status. Cytokine profiles differed between Jamaican and British children. In the Jamaican children they reflected SCD, but not asthma or ACS status.</description><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - immunology</subject><subject>Asthma - blood</subject><subject>Asthma - complications</subject><subject>Asthma - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Humans</subject><subject>Th2 Cells - immunology</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkT1PwzAQhi0EoqUwsiKLhSnFjp34PKKKL6kSCwxMkRtfVLduUuwEqf-ehBYGFqa74bn37vQQcsnZlDPQtysXpinjfMqYYEdkzLNMJUrm2XHfM6UTrZkakbMYV4yxHFJ9SkYp1zzPmRqT99mubdauRurxE32kprZ0G5rKeYzU1bRcOm8D1jSgNy1a2jY0unLtkZboPbUuoon4PWdiu9wYGlvTdvGcnFTGR7w41Al5e7h_nT0l85fH59ndPClFxtsENEoJKVrgAJUUBmQqjUYDCiqdQ47KSsWNWoCsQAulrS3BCsg0MquVmJCbfW5_9UeHsS02Lg6nmRqbLhY6ZcBklor_SZ5zmYEYyOs_5KrpQt2_0UMZl0Lmw-JkD5WhiTFgVWyD25iwKzgrBjdF76YY3BSDm56_OoR2iw3aX_pHhvgCu8eI6g</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Knight-Madden, Jennifer</creator><creator>Vergani, Diego</creator><creator>Patey, Richard</creator><creator>Sylvester, Karl</creator><creator>Hussain, Munther J</creator><creator>Forrester, Terrence</creator><creator>Greenough, Anne</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Cytokine levels and profiles in children related to sickle cell disease and asthma status</title><author>Knight-Madden, Jennifer ; Vergani, Diego ; Patey, Richard ; Sylvester, Karl ; Hussain, Munther J ; Forrester, Terrence ; Greenough, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-89e4482ed8188f43a8424a9ea878f9686e7d471a7b84f89379ddc8d3859e0d973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - immunology</topic><topic>Asthma - blood</topic><topic>Asthma - complications</topic><topic>Asthma - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytokines - blood</topic><topic>Cytokines - immunology</topic><topic>Humans</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knight-Madden, Jennifer</creatorcontrib><creatorcontrib>Vergani, Diego</creatorcontrib><creatorcontrib>Patey, Richard</creatorcontrib><creatorcontrib>Sylvester, Karl</creatorcontrib><creatorcontrib>Hussain, Munther J</creatorcontrib><creatorcontrib>Forrester, Terrence</creatorcontrib><creatorcontrib>Greenough, Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interferon & cytokine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knight-Madden, Jennifer</au><au>Vergani, Diego</au><au>Patey, Richard</au><au>Sylvester, Karl</au><au>Hussain, Munther J</au><au>Forrester, Terrence</au><au>Greenough, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine levels and profiles in children related to sickle cell disease and asthma status</atitle><jtitle>Journal of interferon & cytokine research</jtitle><addtitle>J Interferon Cytokine Res</addtitle><date>2012-01</date><risdate>2012</risdate><volume>32</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>1079-9907</issn><eissn>1557-7465</eissn><abstract>Atopic asthma in patients with sickle cell disease (SCD) is associated with an increased risk of acute chest syndrome (ACS). Cytokine-mediated inflammation might explain this association. Studies of cytokine profiles in patients with SCD have yielded conflicting data, but the possible influence of asthma status has not been examined. Our aim was to test the hypothesis that cytokine levels and profiles in SCD children reflected their asthma status. Samples from 155 Jamaican children (80 had SCD) and 64 British children (53 had SCD) who had their asthma status documented were analyzed for the presence and levels of interleukin 4 (IL-4) and interferon (IFN)-γ; they were also classified by their T helper cell (Th) cytokine profile. Jamaican children with SCD, when compared with Jamaican controls, were more likely to be diagnosed with asthma (P=0.001), more likely to be IL-4 positive (P<0.001), and more likely to be classified as having a Th-2 pattern (<0.001). In contrast, British children with SCD, when compared with the British controls, were less likely to have been diagnosed with asthma (P=0.04) and less likely to be classified as having a Th-2 pattern (P=0.006). Regression analysis demonstrated that amongst Jamaican children, SCD status, but not asthma status, ACS history, or gender, was predictive of IL-4 positivity and Th-2 status (P<0.001). In British children, none of those variables were significant predictors of IL-4 positivity or Th status. Cytokine profiles differed between Jamaican and British children. In the Jamaican children they reflected SCD, but not asthma or ACS status.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>21916607</pmid><doi>10.1089/jir.2011.0030</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of interferon & cytokine research, 2012-01, Vol.32 (1), p.1-5 |
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| subjects | Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - immunology Asthma - blood Asthma - complications Asthma - immunology Child Child, Preschool Cytokines - blood Cytokines - immunology Humans Th2 Cells - immunology |
| title | Cytokine levels and profiles in children related to sickle cell disease and asthma status |
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