Simultaneous detection of multiple mutations in epidermal growth factor receptor based on fluorescence quenching of quantum dots

► We develop a simultaneous detection method for multiple mutations. ► We detect two common mutations in the epidermal growth factor receptor gene. ► Fluorescence quenching due to aggregation of quantum dots is used for detection. ► This enables a simultaneous detection of mutations in exon 19 and 2...

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Veröffentlicht in:	Biosensors & bioelectronics 2012-01, Vol.31 (1), p.558-561
Hauptverfasser:	Kang, Taegyeong, Lee, Hosub, Choe, Dongcheol, Joo, Sang-Woo, Lee, So Yeong, Yoon, Kyong-Ah, Lee, Kangtaek
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology DNA Mutational Analysis - instrumentation DNA Probes - genetics Epidermal growth factor receptor Equipment Design Equipment Failure Analysis Fluorescence Fundamental and applied biological sciences. Psychology Mutation Oligonucleotide Array Sequence Analysis - instrumentation Quantum Dots Quenching Receptor, Epidermal Growth Factor - genetics Reproducibility of Results Sensitivity and Specificity Spectrometry, Fluorescence - instrumentation
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