Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure
The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches...
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Veröffentlicht in: | Cancer biotherapy & radiopharmaceuticals 2011-12, Vol.26 (6), p.737-743 |
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description | The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) (131)I exposure. Six months duration batch received (131)I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before (131)I exposure separately. Increased Technetium-99m-pertechnetate ((99m)TcO(4)(-)) uptake at 30 minutes post injection in salivary glands of only (131)I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only (131)I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to (131)I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure. |
doi_str_mv | 10.1089/cbr.2011.1014 |
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The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) (131)I exposure. Six months duration batch received (131)I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before (131)I exposure separately. Increased Technetium-99m-pertechnetate ((99m)TcO(4)(-)) uptake at 30 minutes post injection in salivary glands of only (131)I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only (131)I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to (131)I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure.</description><identifier>ISSN: 1084-9785</identifier><identifier>EISSN: 1557-8852</identifier><identifier>DOI: 10.1089/cbr.2011.1014</identifier><identifier>PMID: 22087607</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Amifostine - pharmacokinetics ; Amifostine - pharmacology ; Animals ; Female ; Iodine Radioisotopes - pharmacology ; Ocimum - chemistry ; Ocimum sanctum ; Parotid Gland - drug effects ; Parotid Gland - metabolism ; Parotid Gland - pathology ; Parotid Gland - radiation effects ; Phytotherapy - methods ; Plant Preparations - pharmacokinetics ; Plant Preparations - pharmacology ; Radiation-Protective Agents - pharmacokinetics ; Radiation-Protective Agents - pharmacology ; Radiopharmaceuticals - pharmacokinetics ; Radiopharmaceuticals - pharmacology ; Radiotherapy - methods ; Rats ; Rats, Wistar ; Sodium Pertechnetate Tc 99m - pharmacokinetics ; Sodium Pertechnetate Tc 99m - pharmacology ; Tissue Distribution</subject><ispartof>Cancer biotherapy & radiopharmaceuticals, 2011-12, Vol.26 (6), p.737-743</ispartof><rights>(©) Copyright 2011, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-27b043f9df30cd22b69028a02bd5e49baf7788a26d6b903c21c3f40fc74017c83</citedby><cites>FETCH-LOGICAL-c351t-27b043f9df30cd22b69028a02bd5e49baf7788a26d6b903c21c3f40fc74017c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22087607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joseph, Lebana J</creatorcontrib><creatorcontrib>Bhartiya, Uma S</creatorcontrib><creatorcontrib>Raut, Yogita S</creatorcontrib><creatorcontrib>Hawaldar, Rohini W</creatorcontrib><creatorcontrib>Nayak, Yogendra</creatorcontrib><creatorcontrib>Pawar, Yogita P</creatorcontrib><creatorcontrib>Jambhekar, Nirmala A</creatorcontrib><creatorcontrib>Rajan, M G R</creatorcontrib><title>Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure</title><title>Cancer biotherapy & radiopharmaceuticals</title><addtitle>Cancer Biother Radiopharm</addtitle><description>The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) (131)I exposure. Six months duration batch received (131)I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before (131)I exposure separately. Increased Technetium-99m-pertechnetate ((99m)TcO(4)(-)) uptake at 30 minutes post injection in salivary glands of only (131)I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only (131)I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to (131)I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure.</description><subject>Amifostine - pharmacokinetics</subject><subject>Amifostine - pharmacology</subject><subject>Animals</subject><subject>Female</subject><subject>Iodine Radioisotopes - pharmacology</subject><subject>Ocimum - chemistry</subject><subject>Ocimum sanctum</subject><subject>Parotid Gland - drug effects</subject><subject>Parotid Gland - metabolism</subject><subject>Parotid Gland - pathology</subject><subject>Parotid Gland - radiation effects</subject><subject>Phytotherapy - methods</subject><subject>Plant Preparations - pharmacokinetics</subject><subject>Plant Preparations - pharmacology</subject><subject>Radiation-Protective Agents - pharmacokinetics</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Radiopharmaceuticals - pharmacology</subject><subject>Radiotherapy - methods</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium Pertechnetate Tc 99m - 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pharmacokinetics</topic><topic>Amifostine - pharmacology</topic><topic>Animals</topic><topic>Female</topic><topic>Iodine Radioisotopes - pharmacology</topic><topic>Ocimum - chemistry</topic><topic>Ocimum sanctum</topic><topic>Parotid Gland - drug effects</topic><topic>Parotid Gland - metabolism</topic><topic>Parotid Gland - pathology</topic><topic>Parotid Gland - radiation effects</topic><topic>Phytotherapy - methods</topic><topic>Plant Preparations - pharmacokinetics</topic><topic>Plant Preparations - pharmacology</topic><topic>Radiation-Protective Agents - pharmacokinetics</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Radiopharmaceuticals - pharmacology</topic><topic>Radiotherapy - methods</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium Pertechnetate Tc 99m - pharmacokinetics</topic><topic>Sodium Pertechnetate Tc 99m - pharmacology</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joseph, Lebana J</creatorcontrib><creatorcontrib>Bhartiya, Uma S</creatorcontrib><creatorcontrib>Raut, Yogita S</creatorcontrib><creatorcontrib>Hawaldar, Rohini W</creatorcontrib><creatorcontrib>Nayak, Yogendra</creatorcontrib><creatorcontrib>Pawar, Yogita P</creatorcontrib><creatorcontrib>Jambhekar, Nirmala A</creatorcontrib><creatorcontrib>Rajan, M G R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Cancer biotherapy & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joseph, Lebana J</au><au>Bhartiya, Uma S</au><au>Raut, Yogita S</au><au>Hawaldar, Rohini W</au><au>Nayak, Yogendra</au><au>Pawar, Yogita P</au><au>Jambhekar, Nirmala A</au><au>Rajan, M G R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure</atitle><jtitle>Cancer biotherapy & radiopharmaceuticals</jtitle><addtitle>Cancer Biother Radiopharm</addtitle><date>2011-12</date><risdate>2011</risdate><volume>26</volume><issue>6</issue><spage>737</spage><epage>743</epage><pages>737-743</pages><issn>1084-9785</issn><eissn>1557-8852</eissn><abstract>The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) (131)I exposure. Six months duration batch received (131)I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before (131)I exposure separately. Increased Technetium-99m-pertechnetate ((99m)TcO(4)(-)) uptake at 30 minutes post injection in salivary glands of only (131)I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only (131)I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to (131)I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>22087607</pmid><doi>10.1089/cbr.2011.1014</doi><tpages>7</tpages></addata></record> |
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subjects | Amifostine - pharmacokinetics Amifostine - pharmacology Animals Female Iodine Radioisotopes - pharmacology Ocimum - chemistry Ocimum sanctum Parotid Gland - drug effects Parotid Gland - metabolism Parotid Gland - pathology Parotid Gland - radiation effects Phytotherapy - methods Plant Preparations - pharmacokinetics Plant Preparations - pharmacology Radiation-Protective Agents - pharmacokinetics Radiation-Protective Agents - pharmacology Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - pharmacology Radiotherapy - methods Rats Rats, Wistar Sodium Pertechnetate Tc 99m - pharmacokinetics Sodium Pertechnetate Tc 99m - pharmacology Tissue Distribution |
title | Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure |
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