Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure

The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches...

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Veröffentlicht in:Cancer biotherapy & radiopharmaceuticals 2011-12, Vol.26 (6), p.737-743
Hauptverfasser: Joseph, Lebana J, Bhartiya, Uma S, Raut, Yogita S, Hawaldar, Rohini W, Nayak, Yogendra, Pawar, Yogita P, Jambhekar, Nirmala A, Rajan, M G R
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container_end_page 743
container_issue 6
container_start_page 737
container_title Cancer biotherapy & radiopharmaceuticals
container_volume 26
creator Joseph, Lebana J
Bhartiya, Uma S
Raut, Yogita S
Hawaldar, Rohini W
Nayak, Yogendra
Pawar, Yogita P
Jambhekar, Nirmala A
Rajan, M G R
description The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ((131)I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) (131)I exposure. Six months duration batch received (131)I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before (131)I exposure separately. Increased Technetium-99m-pertechnetate ((99m)TcO(4)(-)) uptake at 30 minutes post injection in salivary glands of only (131)I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only (131)I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to (131)I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure.
doi_str_mv 10.1089/cbr.2011.1014
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Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose (131)I exposure.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>22087607</pmid><doi>10.1089/cbr.2011.1014</doi><tpages>7</tpages></addata></record>
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subjects Amifostine - pharmacokinetics
Amifostine - pharmacology
Animals
Female
Iodine Radioisotopes - pharmacology
Ocimum - chemistry
Ocimum sanctum
Parotid Gland - drug effects
Parotid Gland - metabolism
Parotid Gland - pathology
Parotid Gland - radiation effects
Phytotherapy - methods
Plant Preparations - pharmacokinetics
Plant Preparations - pharmacology
Radiation-Protective Agents - pharmacokinetics
Radiation-Protective Agents - pharmacology
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - pharmacology
Radiotherapy - methods
Rats
Rats, Wistar
Sodium Pertechnetate Tc 99m - pharmacokinetics
Sodium Pertechnetate Tc 99m - pharmacology
Tissue Distribution
title Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure
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