Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo
Curcumin, the main compound of spice turmeric, is one of the natural products that has been shown to possess effective anti-cancer properties. However, the absorption efficacy of curcumin is too low to make dramatic results in therapy. Therefore, we based the main aim of this study on improving the...
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| Veröffentlicht in: | International immunopharmacology 2012, Vol.12 (1), p.226-234 |
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| description | Curcumin, the main compound of spice turmeric, is one of the natural products that has been shown to possess effective anti-cancer properties. However, the absorption efficacy of curcumin is too low to make dramatic results in therapy. Therefore, we based the main aim of this study on improving the bioavailability of curcumin taking advantage of dendrosome nanoparticles; and subsequently evaluating
in vitro and
in vivo anti-tumor properties of dendrosomal curcumin.
In vitro studies were carried out utilizing A431 and WEHI-164 cell lines and mouse embryonic normal fibroblasts. Our data revealed that dendrosomal curcumin not only exhibits a much higher bioavailability than void curcumin (P
<
0.05) but also inhibits the proliferation of cancer cells (P
<
0.01) in a time- and dose-dependent manner that could be ascribed to the induction of apoptosis. However, dendrosome did not indicate any toxic effect on different types of cell lines. For
in vivo studies, BALB/c tumor-bearing mice were treated with dendrosomal curcumin, void curcumin, dendrosome and PBS. The results indicated that dendrosomal curcumin reduces significantly the tumor size in comparison with void curcumin and control samples (P
<
0.05). Furthermore, in animals treated with dendrosomal curcumin a longer survival was observed (P
<
0.01). We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-γ production as well as a significant decrease in IL-4 production. This can be a proof of anti-tumor immunity caused by dendrosomal curcumin. The findings demonstrate that dendrosomal curcumin offers a great potential to be a promising anti-cancer therapeutic agent.
► In this study we used dendrosomes to improve the bioavailability of curcumin. ► Dendrosomal curcumin significantly effects cancer cells rather than normal ones. ► Dendrosomal curcumin suppresses tumor growth in vivo. ► This effect is coupled with the induction of immune response. |
| doi_str_mv | 10.1016/j.intimp.2011.11.015 |
| format | Article |
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in vitro and
in vivo anti-tumor properties of dendrosomal curcumin.
In vitro studies were carried out utilizing A431 and WEHI-164 cell lines and mouse embryonic normal fibroblasts. Our data revealed that dendrosomal curcumin not only exhibits a much higher bioavailability than void curcumin (P
<
0.05) but also inhibits the proliferation of cancer cells (P
<
0.01) in a time- and dose-dependent manner that could be ascribed to the induction of apoptosis. However, dendrosome did not indicate any toxic effect on different types of cell lines. For
in vivo studies, BALB/c tumor-bearing mice were treated with dendrosomal curcumin, void curcumin, dendrosome and PBS. The results indicated that dendrosomal curcumin reduces significantly the tumor size in comparison with void curcumin and control samples (P
<
0.05). Furthermore, in animals treated with dendrosomal curcumin a longer survival was observed (P
<
0.01). We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-γ production as well as a significant decrease in IL-4 production. This can be a proof of anti-tumor immunity caused by dendrosomal curcumin. The findings demonstrate that dendrosomal curcumin offers a great potential to be a promising anti-cancer therapeutic agent.
► In this study we used dendrosomes to improve the bioavailability of curcumin. ► Dendrosomal curcumin significantly effects cancer cells rather than normal ones. ► Dendrosomal curcumin suppresses tumor growth in vivo. ► This effect is coupled with the induction of immune response.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2011.11.015</identifier><identifier>PMID: 22155627</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; BALB/c mice ; Biological and medical sciences ; Cancer ; Cell Line ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Curcuma longa ; Curcumin ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Dendrosome ; Drug Carriers - pharmacology ; Drug Carriers - therapeutic use ; Female ; Fibrosarcoma ; Humans ; Interferon-gamma - immunology ; Interleukin-4 - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Nanoparticles - therapeutic use ; Neoplasm Transplantation ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - pathology ; Pharmacology. Drug treatments ; Spleen - cytology ; Spleen - drug effects ; Spleen - immunology ; Tumor Burden - drug effects</subject><ispartof>International immunopharmacology, 2012, Vol.12 (1), p.226-234</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-e1fd51bd6eb7ea43f96281778d23d099b941d8f87eee71ca72c42b915e791bbd3</citedby><cites>FETCH-LOGICAL-c423t-e1fd51bd6eb7ea43f96281778d23d099b941d8f87eee71ca72c42b915e791bbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567576911004553$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25482282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22155627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babaei, Esmaeil</creatorcontrib><creatorcontrib>Sadeghizadeh, Majid</creatorcontrib><creatorcontrib>Hassan, Zuhair Mohammad</creatorcontrib><creatorcontrib>Feizi, Mohammad Ali Hosseinpour</creatorcontrib><creatorcontrib>Najafi, Farhood</creatorcontrib><creatorcontrib>Hashemi, Seyed Mahmoud</creatorcontrib><title>Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Curcumin, the main compound of spice turmeric, is one of the natural products that has been shown to possess effective anti-cancer properties. However, the absorption efficacy of curcumin is too low to make dramatic results in therapy. Therefore, we based the main aim of this study on improving the bioavailability of curcumin taking advantage of dendrosome nanoparticles; and subsequently evaluating
in vitro and
in vivo anti-tumor properties of dendrosomal curcumin.
In vitro studies were carried out utilizing A431 and WEHI-164 cell lines and mouse embryonic normal fibroblasts. Our data revealed that dendrosomal curcumin not only exhibits a much higher bioavailability than void curcumin (P
<
0.05) but also inhibits the proliferation of cancer cells (P
<
0.01) in a time- and dose-dependent manner that could be ascribed to the induction of apoptosis. However, dendrosome did not indicate any toxic effect on different types of cell lines. For
in vivo studies, BALB/c tumor-bearing mice were treated with dendrosomal curcumin, void curcumin, dendrosome and PBS. The results indicated that dendrosomal curcumin reduces significantly the tumor size in comparison with void curcumin and control samples (P
<
0.05). Furthermore, in animals treated with dendrosomal curcumin a longer survival was observed (P
<
0.01). We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-γ production as well as a significant decrease in IL-4 production. This can be a proof of anti-tumor immunity caused by dendrosomal curcumin. The findings demonstrate that dendrosomal curcumin offers a great potential to be a promising anti-cancer therapeutic agent.
► In this study we used dendrosomes to improve the bioavailability of curcumin. ► Dendrosomal curcumin significantly effects cancer cells rather than normal ones. ► Dendrosomal curcumin suppresses tumor growth in vivo. ► This effect is coupled with the induction of immune response.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>BALB/c mice</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Curcuma longa</subject><subject>Curcumin</subject><subject>Curcumin - pharmacology</subject><subject>Curcumin - therapeutic use</subject><subject>Dendrosome</subject><subject>Drug Carriers - pharmacology</subject><subject>Drug Carriers - therapeutic use</subject><subject>Female</subject><subject>Fibrosarcoma</subject><subject>Humans</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-4 - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoparticles - therapeutic use</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>Tumor Burden - drug effects</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFTEQxYNY2lr7DUT2RXza20x2s0leBKm1CgVf9E0I2WRWctl_JrsX-u2dy97qm4WBJMPvTIZzGHsDfAccmpv9Lo5LHOad4AA7Kg7yBbsErXQJisuXdJeNKqVqzAV7lfOec-rXcM4uhAApG6Eu2c9POIY05WlwfeHX5NchjkWOv8bYRe_GpX8s8jrPCXPGXFDHYyo89n0xp6mPHSa3xGksSHWIS5oKN4btcZhes7PO9RmvT-cV-_H57vvtl_Lh2_3X248Ppa9FtZQIXZDQhgZbha6uOtMIDUrpIKrAjWlNDUF3WiGiAu-UIF1rQKIy0LahumLvt7m00u8V82KHmI87uhGnNVsjuOZCVOZ5EpRUslY1kfVGenInJ-zsnOLg0qMFbo8B2L3dArDHACwVBUCyt6cP1nbA8Ff05DgB706Ay971XSJHY_7HyVoLoQVxHzYOybhDxGSzj0juh5jQLzZM8f-b_AHlbqdk</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Babaei, Esmaeil</creator><creator>Sadeghizadeh, Majid</creator><creator>Hassan, Zuhair Mohammad</creator><creator>Feizi, Mohammad Ali Hosseinpour</creator><creator>Najafi, Farhood</creator><creator>Hashemi, Seyed Mahmoud</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>2012</creationdate><title>Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo</title><author>Babaei, Esmaeil ; Sadeghizadeh, Majid ; Hassan, Zuhair Mohammad ; Feizi, Mohammad Ali Hosseinpour ; Najafi, Farhood ; Hashemi, Seyed Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-e1fd51bd6eb7ea43f96281778d23d099b941d8f87eee71ca72c42b915e791bbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>BALB/c mice</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Curcuma longa</topic><topic>Curcumin</topic><topic>Curcumin - pharmacology</topic><topic>Curcumin - therapeutic use</topic><topic>Dendrosome</topic><topic>Drug Carriers - pharmacology</topic><topic>Drug Carriers - therapeutic use</topic><topic>Female</topic><topic>Fibrosarcoma</topic><topic>Humans</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin-4 - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoparticles - therapeutic use</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>Spleen - immunology</topic><topic>Tumor Burden - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babaei, Esmaeil</creatorcontrib><creatorcontrib>Sadeghizadeh, Majid</creatorcontrib><creatorcontrib>Hassan, Zuhair Mohammad</creatorcontrib><creatorcontrib>Feizi, Mohammad Ali Hosseinpour</creatorcontrib><creatorcontrib>Najafi, Farhood</creatorcontrib><creatorcontrib>Hashemi, Seyed Mahmoud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babaei, Esmaeil</au><au>Sadeghizadeh, Majid</au><au>Hassan, Zuhair Mohammad</au><au>Feizi, Mohammad Ali Hosseinpour</au><au>Najafi, Farhood</au><au>Hashemi, Seyed Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2012</date><risdate>2012</risdate><volume>12</volume><issue>1</issue><spage>226</spage><epage>234</epage><pages>226-234</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Curcumin, the main compound of spice turmeric, is one of the natural products that has been shown to possess effective anti-cancer properties. However, the absorption efficacy of curcumin is too low to make dramatic results in therapy. Therefore, we based the main aim of this study on improving the bioavailability of curcumin taking advantage of dendrosome nanoparticles; and subsequently evaluating
in vitro and
in vivo anti-tumor properties of dendrosomal curcumin.
In vitro studies were carried out utilizing A431 and WEHI-164 cell lines and mouse embryonic normal fibroblasts. Our data revealed that dendrosomal curcumin not only exhibits a much higher bioavailability than void curcumin (P
<
0.05) but also inhibits the proliferation of cancer cells (P
<
0.01) in a time- and dose-dependent manner that could be ascribed to the induction of apoptosis. However, dendrosome did not indicate any toxic effect on different types of cell lines. For
in vivo studies, BALB/c tumor-bearing mice were treated with dendrosomal curcumin, void curcumin, dendrosome and PBS. The results indicated that dendrosomal curcumin reduces significantly the tumor size in comparison with void curcumin and control samples (P
<
0.05). Furthermore, in animals treated with dendrosomal curcumin a longer survival was observed (P
<
0.01). We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-γ production as well as a significant decrease in IL-4 production. This can be a proof of anti-tumor immunity caused by dendrosomal curcumin. The findings demonstrate that dendrosomal curcumin offers a great potential to be a promising anti-cancer therapeutic agent.
► In this study we used dendrosomes to improve the bioavailability of curcumin. ► Dendrosomal curcumin significantly effects cancer cells rather than normal ones. ► Dendrosomal curcumin suppresses tumor growth in vivo. ► This effect is coupled with the induction of immune response.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22155627</pmid><doi>10.1016/j.intimp.2011.11.015</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use BALB/c mice Biological and medical sciences Cancer Cell Line Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Curcuma longa Curcumin Curcumin - pharmacology Curcumin - therapeutic use Dendrosome Drug Carriers - pharmacology Drug Carriers - therapeutic use Female Fibrosarcoma Humans Interferon-gamma - immunology Interleukin-4 - immunology Medical sciences Mice Mice, Inbred BALB C Nanoparticles - therapeutic use Neoplasm Transplantation Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology Pharmacology. Drug treatments Spleen - cytology Spleen - drug effects Spleen - immunology Tumor Burden - drug effects |
| title | Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo |
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