Isolation of single, intact chromosomes from single, selected ovarian cancer cells for in situ hybridization and sequencing

The first step towards effective therapy of cancer is to reveal molecular profiles of all cell clones propelling tumor growth. The specific aim of this project was to develop a technology helping us to isolate patient's single, living cells based upon their cancer-specific, cell surface biomark...

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Veröffentlicht in:	Gene 2012-02, Vol.493 (1), p.132-139
Hauptverfasser:	Malecki, Marek, Szybalski, Waclaw
Format:	Artikel
Sprache:	eng
Schlagworte:	animal ovaries biomarkers blood Chromosome 7 chromosomes Chromosomes - genetics clones DNA, Recombinant Epidermal growth factor receptor gene mutation deletion variant III (EGFRvIII) Female fluorescence in situ hybridization Fluorescent in situ hybridization Gene Targeting Gene therapy genes growth factors high-throughput nucleotide sequencing Humans image analysis In Situ Hybridization, Fluorescence lymph Next generation sequencing Ovarian cancer ovarian neoplasms Ovarian Neoplasms - genetics patients Receptor, Epidermal Growth Factor - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Single-Chain Antibodies - genetics therapeutics
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