Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats

J. Neurochem. (2012) 120, 564–573. Focal cerebral cortical infarction after distal middle cerebral artery occlusion causes β‐amyloid deposition and secondary neuronal degeneration in the ipsilateral ventroposterior nucleus of the thalamus. Several studies suggest that autophagy is an active pathway...

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Veröffentlicht in:	Journal of neurochemistry 2012-02, Vol.120 (4), p.564-573
Hauptverfasser:	Zhang, Jian, Zhang, Yusheng, Li, Jingjing, Xing, Shihui, Li, Chuo, Li, Yiliang, Dang, Chao, Fan, Yuhua, Yu, Jian, Pei, Zhong, Zeng, Jinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	3-methyladenine Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - physiology Amyloid precursor protein Amyloid Precursor Protein Secretases - biosynthesis Amyloid Precursor Protein Secretases - physiology Animals Arterial hypertension. Arterial hypotension Aspartic Acid Endopeptidases - biosynthesis Aspartic Acid Endopeptidases - physiology autophagy Autophagy - physiology beta -Amyloid Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cerebral blood flow Cerebral infarction Cerebral Infarction - enzymology Cerebral Infarction - metabolism Cerebral Infarction - pathology Degeneration Deposits Enzymes Fluorescence Hypertension - enzymology Hypertension - metabolism Hypertension - pathology Infarction Ischemia Light chains Male Medical sciences Microtubule-associated protein 1 Nerve Degeneration - enzymology Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurology Phagocytosis Phagosomes Phagosomes - enzymology Phagosomes - metabolism Phagosomes - pathology Plaque, Amyloid - enzymology Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Rats Rats, Sprague-Dawley Thalamus Thalamus - enzymology Thalamus - metabolism Thalamus - pathology Vascular diseases and vascular malformations of the nervous system β-amyloid β-secretase
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