Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease
Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL‐8 and TNF‐α in patients with COPD during the stable pha...
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| Veröffentlicht in: | Scandinavian journal of immunology 2012-01, Vol.75 (1), p.109-114 |
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| creator | Kristan, S. S. Marc, M. M. Kern, I. Flezar, M. Suskovic, S. Kosnik, M. Korosec, P. |
| description | Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL‐8 and TNF‐α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non‐smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL‐8, TNF‐α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P |
| doi_str_mv | 10.1111/j.1365-3083.2011.02623.x |
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S. ; Marc, M. M. ; Kern, I. ; Flezar, M. ; Suskovic, S. ; Kosnik, M. ; Korosec, P.</creator><creatorcontrib>Kristan, S. S. ; Marc, M. M. ; Kern, I. ; Flezar, M. ; Suskovic, S. ; Kosnik, M. ; Korosec, P.</creatorcontrib><description><![CDATA[Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL‐8 and TNF‐α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non‐smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL‐8, TNF‐α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P < 0.001, P = 0.02), angiogenin (P < 0.0001, P < 0.0001), IL‐8 (P < 0.0001, P = 0.0021) and TNF‐α (P < 0.001, P = 0.03) were significantly elevated in comparison with healthy smokers and non‐smokers. No additional elevation of angiogenic factors was demonstrated at the time of exacerbation. There was a significant negative correlation between FEV1 and VEGF (P < 0.05, r = −0.38), angiogenin (P < 0.0001, r = −0.68) and IL‐8 (P < 0.001, r = −0.54) among smokers (smoking COPD patients and healthy smokers). No significant differences were observed between groups of healthy smokers and non‐smokers. These results showed increased airway angiogenesis in patients with COPD. Moreover, VEGF, IL‐8 and angiogenin negatively correlated with pulmonary function, which suggests their important role in COPD airway remodelling. However, no additional angiogenic activation was found during exacerbation of COPD.]]></description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.2011.02623.x</identifier><identifier>PMID: 21916917</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Angiogenesis ; Angiogenin ; Chronic obstructive pulmonary disease ; Female ; Fibroblast growth factor 2 ; Fibroblast Growth Factor 2 - metabolism ; Flow Cytometry ; Humans ; Interleukin 8 ; Interleukin-8 - metabolism ; Lung - blood supply ; Male ; Middle Aged ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Pulmonary Disease, Chronic Obstructive - metabolism ; Pulmonary Disease, Chronic Obstructive - pathology ; Respiratory Function Tests ; Respiratory tract diseases ; Ribonuclease, Pancreatic - metabolism ; Smoking ; Sputum ; Sputum - metabolism ; Statistics, Nonparametric ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - metabolism ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - metabolism ; Young Adult</subject><ispartof>Scandinavian journal of immunology, 2012-01, Vol.75 (1), p.109-114</ispartof><rights>2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd</rights><rights>2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5543-6a5fa559183afc3f6bb6504e442d2d6570bf9aa506245bec6d14365484ca0ba83</citedby><cites>FETCH-LOGICAL-c5543-6a5fa559183afc3f6bb6504e442d2d6570bf9aa506245bec6d14365484ca0ba83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-3083.2011.02623.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-3083.2011.02623.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21916917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kristan, S. S.</creatorcontrib><creatorcontrib>Marc, M. M.</creatorcontrib><creatorcontrib>Kern, I.</creatorcontrib><creatorcontrib>Flezar, M.</creatorcontrib><creatorcontrib>Suskovic, S.</creatorcontrib><creatorcontrib>Kosnik, M.</creatorcontrib><creatorcontrib>Korosec, P.</creatorcontrib><title>Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description><![CDATA[Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL‐8 and TNF‐α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non‐smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL‐8, TNF‐α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P < 0.001, P = 0.02), angiogenin (P < 0.0001, P < 0.0001), IL‐8 (P < 0.0001, P = 0.0021) and TNF‐α (P < 0.001, P = 0.03) were significantly elevated in comparison with healthy smokers and non‐smokers. No additional elevation of angiogenic factors was demonstrated at the time of exacerbation. There was a significant negative correlation between FEV1 and VEGF (P < 0.05, r = −0.38), angiogenin (P < 0.0001, r = −0.68) and IL‐8 (P < 0.001, r = −0.54) among smokers (smoking COPD patients and healthy smokers). No significant differences were observed between groups of healthy smokers and non‐smokers. These results showed increased airway angiogenesis in patients with COPD. Moreover, VEGF, IL‐8 and angiogenin negatively correlated with pulmonary function, which suggests their important role in COPD airway remodelling. However, no additional angiogenic activation was found during exacerbation of COPD.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Angiogenin</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Female</subject><subject>Fibroblast growth factor 2</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Interleukin 8</subject><subject>Interleukin-8 - metabolism</subject><subject>Lung - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory tract diseases</subject><subject>Ribonuclease, Pancreatic - metabolism</subject><subject>Smoking</subject><subject>Sputum</subject><subject>Sputum - metabolism</subject><subject>Statistics, Nonparametric</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Young Adult</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu2zAQRYmgQeIk_YWCu66k8C1pkYXh5lU4D8BtsyRIapTQlSWXlBr77yPVqbctN0Ngzh1yDkKYkpQO53yZUq5kwknOU0YoTQlTjKebAzTZNz6gCeGEJIXI5DE6iXFJCOUs40fomNGCqoJmE7SY-vBqtnjaPPv2GRqIPmLf4EVnbA3YNCW-3BgHwZoOSjx7CW3jHX6wsQu96_xvwI99vWobE7b4i49gIpyhw8rUET6-11P0_ery2-wmmT9c386m88RJKXiijKyMlAXNuakcr5S1ShIBQrCSlUpmxFaFMZIoJqQFp0oqhuVELpwh1uT8FH3ezV2H9lcPsdMrHx3UtWmg7aMuGMmKXEjyb5LSQrDhIwOZ70gX2hgDVHod_GpYTlOiR_d6qUfFelSsR_f6j3u9GaKf3h_p7QrKffCv7AG42AGvvobtfw_Wi6-3423IJ7u8jx1s9nkTfmqV8Uzqp_trPb-6E-Tux5Pm_A36AqDy</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Kristan, S. S.</creator><creator>Marc, M. M.</creator><creator>Kern, I.</creator><creator>Flezar, M.</creator><creator>Suskovic, S.</creator><creator>Kosnik, M.</creator><creator>Korosec, P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201201</creationdate><title>Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease</title><author>Kristan, S. S. ; Marc, M. M. ; Kern, I. ; Flezar, M. ; Suskovic, S. ; Kosnik, M. ; Korosec, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5543-6a5fa559183afc3f6bb6504e442d2d6570bf9aa506245bec6d14365484ca0ba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Angiogenin</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Female</topic><topic>Fibroblast growth factor 2</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Interleukin 8</topic><topic>Interleukin-8 - metabolism</topic><topic>Lung - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory tract diseases</topic><topic>Ribonuclease, Pancreatic - metabolism</topic><topic>Smoking</topic><topic>Sputum</topic><topic>Sputum - metabolism</topic><topic>Statistics, Nonparametric</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kristan, S. S.</creatorcontrib><creatorcontrib>Marc, M. M.</creatorcontrib><creatorcontrib>Kern, I.</creatorcontrib><creatorcontrib>Flezar, M.</creatorcontrib><creatorcontrib>Suskovic, S.</creatorcontrib><creatorcontrib>Kosnik, M.</creatorcontrib><creatorcontrib>Korosec, P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kristan, S. S.</au><au>Marc, M. M.</au><au>Kern, I.</au><au>Flezar, M.</au><au>Suskovic, S.</au><au>Kosnik, M.</au><au>Korosec, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>75</volume><issue>1</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract><![CDATA[Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL‐8 and TNF‐α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non‐smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL‐8, TNF‐α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P < 0.001, P = 0.02), angiogenin (P < 0.0001, P < 0.0001), IL‐8 (P < 0.0001, P = 0.0021) and TNF‐α (P < 0.001, P = 0.03) were significantly elevated in comparison with healthy smokers and non‐smokers. No additional elevation of angiogenic factors was demonstrated at the time of exacerbation. There was a significant negative correlation between FEV1 and VEGF (P < 0.05, r = −0.38), angiogenin (P < 0.0001, r = −0.68) and IL‐8 (P < 0.001, r = −0.54) among smokers (smoking COPD patients and healthy smokers). No significant differences were observed between groups of healthy smokers and non‐smokers. These results showed increased airway angiogenesis in patients with COPD. Moreover, VEGF, IL‐8 and angiogenin negatively correlated with pulmonary function, which suggests their important role in COPD airway remodelling. However, no additional angiogenic activation was found during exacerbation of COPD.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21916917</pmid><doi>10.1111/j.1365-3083.2011.02623.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Angiogenesis Angiogenin Chronic obstructive pulmonary disease Female Fibroblast growth factor 2 Fibroblast Growth Factor 2 - metabolism Flow Cytometry Humans Interleukin 8 Interleukin-8 - metabolism Lung - blood supply Male Middle Aged Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Respiratory Function Tests Respiratory tract diseases Ribonuclease, Pancreatic - metabolism Smoking Sputum Sputum - metabolism Statistics, Nonparametric Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Young Adult |
| title | Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease |
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