PML contributes to p53-independent p21 up-regulation in gamma-irradiation induced DNA damage responses

The cyclin-dependent kinase inhibitor p21wAF1/cipl is a critical cell cycle regulator which translocates into the nucleus to participate in DNA repair during DNA damage responses. In the present study, we showed that the tumor suppressor, promyelocytic leukemia protein （PML） contributes to the up-re...

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Veröffentlicht in:	Chinese science bulletin 2011-10, Vol.56 (30), p.3148-3154, Article 3148
Hauptverfasser:	Cao, Lin, Song, Yi, Tian, BaoLei, Liu, JiLai, Liu, Bin, Zhang, JiaNing, Sun, ZhiXian
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Chemistry/Food Science cyclin-dependent kinase DNA damage DNA repair DNA损伤 Earth Sciences Engineering gamma radiation gene expression regulation half life Humanities and Social Sciences leukemia Life Sciences multidisciplinary P21 P53 Physics PML proliferating cell nuclear antigen protein synthesis proteolysis Science Science (multidisciplinary) small interfering RNA γ射线照射反应增殖细胞核抗原细胞周期蛋白
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