Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases

The pathogenic agent responsible for the expanded repeat diseases, a group of neurodegenerative diseases that includes Huntington's disease is not yet fully understood. Expanded polyglutamine (polyQ) is thought to be the toxic agent in certain cases, however, not all expanded repeat disease gen...

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Veröffentlicht in:Human molecular genetics 2011-10, Vol.20 (19), p.3757-3768
Hauptverfasser: Lawlor, Kynan T., O'Keefe, Louise V., Samaraweera, Saumya E., van Eyk, Clare L., McLeod, Catherine J., Maloney, Christopher A., Dang, Thurston H.Y., Suter, Catherine M., Richards, Robert I.
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