Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules
Abstract Objective The purpose of the study was to differentiate between benign and malignant thyroid nodules using nodule-spinal cord signal intensity and nodule apparent diffusion coefficient (ADC) ratios on diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods Forty-four p...
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| creator | Mutlu, Hakan Sivrioglu, Ali Kemal Sonmez, Guner Velioglu, Murat Sildiroglu, Huseyin Onur Basekim, Cihat Cinar Kizilkaya, Esref |
| description | Abstract Objective The purpose of the study was to differentiate between benign and malignant thyroid nodules using nodule-spinal cord signal intensity and nodule apparent diffusion coefficient (ADC) ratios on diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods Forty-four patients (27 females, 17 males; mean age, 49 years) with nodules who underwent DW-MRI were included in this study. The images were acquired with 0, 50, 400 and 1000 s/mm2 b values. ADC maps were calculated afterwards. Fine needle aspiration biopsies (FNAB) were performed at the same day with DW-MRI acquisition. The diagnosis in patients where malignity was detected after FNAB was confirmed by histopathologic analysis of the operation material. The signal intensities of the spinal cord and the nodule were measured additionally, over b-1000 diffusion-weighted images. Nodule/cord signal intensity (SI) ratios were obtained and the digital values were calculated by dividing to ADC values estimated for each nodule. Statistical analysis was performed. Results The (nodule SI-cord SI)/nodule ADC ratio is calculated in the DW images, and a statistically significant relationship was found between this ratio and the histopathology of the nodules ( P |
| doi_str_mv | 10.1016/j.clinimag.2011.04.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_920793004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0899707111000805</els_id><sourcerecordid>2733152981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-9e998a2e2b24a00ae10defe10525db2ccdb19fbd111d9c7249f93881efc0fa2e3</originalsourceid><addsrcrecordid>eNqFkl1vFCEUhidGY7fVv9CQeOHVjAfmkxujabSaNDHx45owcNiyzsIKM2321_hXhd3WJr0pF0DIc97z8VIU5xQqCrR7t6nUZJ3dynXFgNIKmgqAPitWdOjrsmk4f16sYOC87KGnJ8VpjJsEdLzpXxYnLK2uqdtV8fe7n5B4Q-RuJwO6mWhrzBKtd0R5NMYqm19v5LRgJNLpB6C8Rbu-nlGTVIbD2SoSMHonnUKSS7NuTaw7BGDWtnLOuiPOt4j5dHbtDppbOaWrTInm633wVhPn9TJhfFW8MHKK-PruPCt-ff708-JLefXt8uvFx6tSNQObS46cD5IhG1kjASRS0GjS3rJWj0wpPVJuRk0p1Vz1rOGG18NA0SgwKa4-K94edXfB_0mdzmJro8Jpkg79EgVn0PMaoHmapC3UQzdAIt88Ijd-CS61ISjUjHc9dJnqjpQKPsaARuxCGl7YJ0hkr8VG3HststcCGpGsTIHnd_LLuEX9P-ze3AR8OAKYBndjMYiYzVSobUA1C-3t0zneP5I4YEpOv3GP8aEfEZkA8SP_uPzhKAWAAdr6HwjP1t8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1032967060</pqid></control><display><type>article</type><title>Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Mutlu, Hakan ; Sivrioglu, Ali Kemal ; Sonmez, Guner ; Velioglu, Murat ; Sildiroglu, Huseyin Onur ; Basekim, Cihat Cinar ; Kizilkaya, Esref</creator><creatorcontrib>Mutlu, Hakan ; Sivrioglu, Ali Kemal ; Sonmez, Guner ; Velioglu, Murat ; Sildiroglu, Huseyin Onur ; Basekim, Cihat Cinar ; Kizilkaya, Esref</creatorcontrib><description>Abstract Objective The purpose of the study was to differentiate between benign and malignant thyroid nodules using nodule-spinal cord signal intensity and nodule apparent diffusion coefficient (ADC) ratios on diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods Forty-four patients (27 females, 17 males; mean age, 49 years) with nodules who underwent DW-MRI were included in this study. The images were acquired with 0, 50, 400 and 1000 s/mm2 b values. ADC maps were calculated afterwards. Fine needle aspiration biopsies (FNAB) were performed at the same day with DW-MRI acquisition. The diagnosis in patients where malignity was detected after FNAB was confirmed by histopathologic analysis of the operation material. The signal intensities of the spinal cord and the nodule were measured additionally, over b-1000 diffusion-weighted images. Nodule/cord signal intensity (SI) ratios were obtained and the digital values were calculated by dividing to ADC values estimated for each nodule. Statistical analysis was performed. Results The (nodule SI-cord SI)/nodule ADC ratio is calculated in the DW images, and a statistically significant relationship was found between this ratio and the histopathology of the nodules ( P <.001). The ratio was determined as 0.27 in benign and 0.86 in malignant lesions. The result of receiver operating characteristic (ROC) analysis was statistically significant, and the area under curve (100%) was considerably high. The threshold value was calculated as 0.56 according to the ROC analysis. According to this threshold value, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rates for (nodule SI/cord SI)/ADC ratios in differentiating benign from malignant thyroid nodules are calculated as 100%, 97%, 83%, 100%, and 98%, respectively. Conclusion We have found that (nodule/cord SI)/nodule ADC ratio has the highest values for sensitivity and specificity among the tests defined for characterization of nodules.</description><identifier>ISSN: 0899-7071</identifier><identifier>EISSN: 1873-4499</identifier><identifier>DOI: 10.1016/j.clinimag.2011.04.001</identifier><identifier>PMID: 22226435</identifier><identifier>CODEN: CLIMEB</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ADC ratio ; Adult ; Aged ; Algorithms ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion weighted magnetic resonance imaging ; Female ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Male ; Middle Aged ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Thyroid nodule ; Thyroid Nodule - diagnosis</subject><ispartof>Clinical imaging, 2012-01, Vol.36 (1), p.1-7</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-9e998a2e2b24a00ae10defe10525db2ccdb19fbd111d9c7249f93881efc0fa2e3</citedby><cites>FETCH-LOGICAL-c482t-9e998a2e2b24a00ae10defe10525db2ccdb19fbd111d9c7249f93881efc0fa2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinimag.2011.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22226435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mutlu, Hakan</creatorcontrib><creatorcontrib>Sivrioglu, Ali Kemal</creatorcontrib><creatorcontrib>Sonmez, Guner</creatorcontrib><creatorcontrib>Velioglu, Murat</creatorcontrib><creatorcontrib>Sildiroglu, Huseyin Onur</creatorcontrib><creatorcontrib>Basekim, Cihat Cinar</creatorcontrib><creatorcontrib>Kizilkaya, Esref</creatorcontrib><title>Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules</title><title>Clinical imaging</title><addtitle>Clin Imaging</addtitle><description>Abstract Objective The purpose of the study was to differentiate between benign and malignant thyroid nodules using nodule-spinal cord signal intensity and nodule apparent diffusion coefficient (ADC) ratios on diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods Forty-four patients (27 females, 17 males; mean age, 49 years) with nodules who underwent DW-MRI were included in this study. The images were acquired with 0, 50, 400 and 1000 s/mm2 b values. ADC maps were calculated afterwards. Fine needle aspiration biopsies (FNAB) were performed at the same day with DW-MRI acquisition. The diagnosis in patients where malignity was detected after FNAB was confirmed by histopathologic analysis of the operation material. The signal intensities of the spinal cord and the nodule were measured additionally, over b-1000 diffusion-weighted images. Nodule/cord signal intensity (SI) ratios were obtained and the digital values were calculated by dividing to ADC values estimated for each nodule. Statistical analysis was performed. Results The (nodule SI-cord SI)/nodule ADC ratio is calculated in the DW images, and a statistically significant relationship was found between this ratio and the histopathology of the nodules ( P <.001). The ratio was determined as 0.27 in benign and 0.86 in malignant lesions. The result of receiver operating characteristic (ROC) analysis was statistically significant, and the area under curve (100%) was considerably high. The threshold value was calculated as 0.56 according to the ROC analysis. According to this threshold value, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rates for (nodule SI/cord SI)/ADC ratios in differentiating benign from malignant thyroid nodules are calculated as 100%, 97%, 83%, 100%, and 98%, respectively. Conclusion We have found that (nodule/cord SI)/nodule ADC ratio has the highest values for sensitivity and specificity among the tests defined for characterization of nodules.</description><subject>ADC ratio</subject><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Diagnosis, Differential</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion weighted magnetic resonance imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid nodule</subject><subject>Thyroid Nodule - diagnosis</subject><issn>0899-7071</issn><issn>1873-4499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1vFCEUhidGY7fVv9CQeOHVjAfmkxujabSaNDHx45owcNiyzsIKM2321_hXhd3WJr0pF0DIc97z8VIU5xQqCrR7t6nUZJ3dynXFgNIKmgqAPitWdOjrsmk4f16sYOC87KGnJ8VpjJsEdLzpXxYnLK2uqdtV8fe7n5B4Q-RuJwO6mWhrzBKtd0R5NMYqm19v5LRgJNLpB6C8Rbu-nlGTVIbD2SoSMHonnUKSS7NuTaw7BGDWtnLOuiPOt4j5dHbtDppbOaWrTInm633wVhPn9TJhfFW8MHKK-PruPCt-ff708-JLefXt8uvFx6tSNQObS46cD5IhG1kjASRS0GjS3rJWj0wpPVJuRk0p1Vz1rOGG18NA0SgwKa4-K94edXfB_0mdzmJro8Jpkg79EgVn0PMaoHmapC3UQzdAIt88Ijd-CS61ISjUjHc9dJnqjpQKPsaARuxCGl7YJ0hkr8VG3HststcCGpGsTIHnd_LLuEX9P-ze3AR8OAKYBndjMYiYzVSobUA1C-3t0zneP5I4YEpOv3GP8aEfEZkA8SP_uPzhKAWAAdr6HwjP1t8</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Mutlu, Hakan</creator><creator>Sivrioglu, Ali Kemal</creator><creator>Sonmez, Guner</creator><creator>Velioglu, Murat</creator><creator>Sildiroglu, Huseyin Onur</creator><creator>Basekim, Cihat Cinar</creator><creator>Kizilkaya, Esref</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20120101</creationdate><title>Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules</title><author>Mutlu, Hakan ; Sivrioglu, Ali Kemal ; Sonmez, Guner ; Velioglu, Murat ; Sildiroglu, Huseyin Onur ; Basekim, Cihat Cinar ; Kizilkaya, Esref</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-9e998a2e2b24a00ae10defe10525db2ccdb19fbd111d9c7249f93881efc0fa2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ADC ratio</topic><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Diagnosis, Differential</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion weighted magnetic resonance imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Thyroid nodule</topic><topic>Thyroid Nodule - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mutlu, Hakan</creatorcontrib><creatorcontrib>Sivrioglu, Ali Kemal</creatorcontrib><creatorcontrib>Sonmez, Guner</creatorcontrib><creatorcontrib>Velioglu, Murat</creatorcontrib><creatorcontrib>Sildiroglu, Huseyin Onur</creatorcontrib><creatorcontrib>Basekim, Cihat Cinar</creatorcontrib><creatorcontrib>Kizilkaya, Esref</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Clinical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mutlu, Hakan</au><au>Sivrioglu, Ali Kemal</au><au>Sonmez, Guner</au><au>Velioglu, Murat</au><au>Sildiroglu, Huseyin Onur</au><au>Basekim, Cihat Cinar</au><au>Kizilkaya, Esref</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules</atitle><jtitle>Clinical imaging</jtitle><addtitle>Clin Imaging</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>36</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0899-7071</issn><eissn>1873-4499</eissn><coden>CLIMEB</coden><abstract>Abstract Objective The purpose of the study was to differentiate between benign and malignant thyroid nodules using nodule-spinal cord signal intensity and nodule apparent diffusion coefficient (ADC) ratios on diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods Forty-four patients (27 females, 17 males; mean age, 49 years) with nodules who underwent DW-MRI were included in this study. The images were acquired with 0, 50, 400 and 1000 s/mm2 b values. ADC maps were calculated afterwards. Fine needle aspiration biopsies (FNAB) were performed at the same day with DW-MRI acquisition. The diagnosis in patients where malignity was detected after FNAB was confirmed by histopathologic analysis of the operation material. The signal intensities of the spinal cord and the nodule were measured additionally, over b-1000 diffusion-weighted images. Nodule/cord signal intensity (SI) ratios were obtained and the digital values were calculated by dividing to ADC values estimated for each nodule. Statistical analysis was performed. Results The (nodule SI-cord SI)/nodule ADC ratio is calculated in the DW images, and a statistically significant relationship was found between this ratio and the histopathology of the nodules ( P <.001). The ratio was determined as 0.27 in benign and 0.86 in malignant lesions. The result of receiver operating characteristic (ROC) analysis was statistically significant, and the area under curve (100%) was considerably high. The threshold value was calculated as 0.56 according to the ROC analysis. According to this threshold value, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rates for (nodule SI/cord SI)/ADC ratios in differentiating benign from malignant thyroid nodules are calculated as 100%, 97%, 83%, 100%, and 98%, respectively. Conclusion We have found that (nodule/cord SI)/nodule ADC ratio has the highest values for sensitivity and specificity among the tests defined for characterization of nodules.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22226435</pmid><doi>10.1016/j.clinimag.2011.04.001</doi><tpages>7</tpages></addata></record> |
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| subjects | ADC ratio Adult Aged Algorithms Diagnosis, Differential Diffusion Magnetic Resonance Imaging - methods Diffusion weighted magnetic resonance imaging Female Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Male Middle Aged Radiology Reproducibility of Results Sensitivity and Specificity Thyroid nodule Thyroid Nodule - diagnosis |
| title | Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules |
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