Autoimmune Syndrome Induced by Adjuvants (ASIA) in the Middle East: morphea following silicone implantation
Morphea and other scleroderma-like skin conditions are occasionally linked with exposure to chemical compounds such as silicone. We treated a 56-year-old woman with generalized severe skin induration accompanied with systemic symptoms and peripheral eosinophilia, which appeared 2.5 years after breas...
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| Veröffentlicht in: | Lupus 2012-02, Vol.21 (2), p.136-139 |
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| creator | Kivity, S Katz, M Langevitz, P Eshed, I Olchovski, D Barzilai, A |
| description | Morphea and other scleroderma-like skin conditions are occasionally linked with exposure to chemical compounds such as silicone. We treated a 56-year-old woman with generalized severe skin induration accompanied with systemic symptoms and peripheral eosinophilia, which appeared 2.5 years after breast silicone implantation and abdominal liposuction. Blood test results and histopathological examination of her skin suggested the diagnosis of morphea overlapping with eosinophilic fasciitis. Her skin disease was presumed to be an autoimmune reaction to silicone implantation. While the removal of the implants did not improve her illness, treatment with 1 mg/kg prednisone and PUVA bath was initiated, with some improvement. This patient illustrates an example of ASIA (Autoimmune Syndrome Induced by Adjuvants), as her disease appeared following exposure to an adjuvant stimulus, with ‘typical’, although not well-defined, autoimmune manifestations. |
| doi_str_mv | 10.1177/0961203311429551 |
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We treated a 56-year-old woman with generalized severe skin induration accompanied with systemic symptoms and peripheral eosinophilia, which appeared 2.5 years after breast silicone implantation and abdominal liposuction. Blood test results and histopathological examination of her skin suggested the diagnosis of morphea overlapping with eosinophilic fasciitis. Her skin disease was presumed to be an autoimmune reaction to silicone implantation. While the removal of the implants did not improve her illness, treatment with 1 mg/kg prednisone and PUVA bath was initiated, with some improvement. This patient illustrates an example of ASIA (Autoimmune Syndrome Induced by Adjuvants), as her disease appeared following exposure to an adjuvant stimulus, with ‘typical’, although not well-defined, autoimmune manifestations.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203311429551</identifier><identifier>PMID: 22235043</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abdomen ; Adjuvants, Immunologic - adverse effects ; Autoimmune diseases ; Autoimmune Diseases - chemically induced ; Autoimmune Diseases - immunology ; Biopsy ; Breast implants ; Breast Implants - adverse effects ; Chemical compounds ; Eosinophilia - etiology ; Eosinophilia - immunology ; Eosinophilia - pathology ; Fasciitis - etiology ; Fasciitis - immunology ; Fasciitis - pathology ; Female ; Humans ; Liposuction ; Lupus ; Medicine ; Middle Aged ; Middle East ; Scleroderma ; Scleroderma, Localized - etiology ; Scleroderma, Localized - immunology ; Scleroderma, Localized - pathology ; Silicones ; Silicones - adverse effects ; Skin diseases ; Surgical outcomes</subject><ispartof>Lupus, 2012-02, Vol.21 (2), p.136-139</ispartof><rights>The Author(s), 2012. 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Katz, M ; Langevitz, P ; Eshed, I ; Olchovski, D ; Barzilai, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-65a495ed93615f3b1292cb581dd8a1049a9b2712ff59332577ffbab0752947393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdomen</topic><topic>Adjuvants, Immunologic - adverse effects</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - chemically induced</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biopsy</topic><topic>Breast implants</topic><topic>Breast Implants - adverse effects</topic><topic>Chemical compounds</topic><topic>Eosinophilia - etiology</topic><topic>Eosinophilia - immunology</topic><topic>Eosinophilia - pathology</topic><topic>Fasciitis - etiology</topic><topic>Fasciitis - immunology</topic><topic>Fasciitis - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Liposuction</topic><topic>Lupus</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Middle East</topic><topic>Scleroderma</topic><topic>Scleroderma, Localized - etiology</topic><topic>Scleroderma, Localized - immunology</topic><topic>Scleroderma, Localized - pathology</topic><topic>Silicones</topic><topic>Silicones - adverse effects</topic><topic>Skin diseases</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kivity, S</creatorcontrib><creatorcontrib>Katz, M</creatorcontrib><creatorcontrib>Langevitz, P</creatorcontrib><creatorcontrib>Eshed, I</creatorcontrib><creatorcontrib>Olchovski, D</creatorcontrib><creatorcontrib>Barzilai, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kivity, S</au><au>Katz, M</au><au>Langevitz, P</au><au>Eshed, I</au><au>Olchovski, D</au><au>Barzilai, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune Syndrome Induced by Adjuvants (ASIA) in the Middle East: morphea following silicone implantation</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2012-02</date><risdate>2012</risdate><volume>21</volume><issue>2</issue><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Morphea and other scleroderma-like skin conditions are occasionally linked with exposure to chemical compounds such as silicone. We treated a 56-year-old woman with generalized severe skin induration accompanied with systemic symptoms and peripheral eosinophilia, which appeared 2.5 years after breast silicone implantation and abdominal liposuction. Blood test results and histopathological examination of her skin suggested the diagnosis of morphea overlapping with eosinophilic fasciitis. Her skin disease was presumed to be an autoimmune reaction to silicone implantation. While the removal of the implants did not improve her illness, treatment with 1 mg/kg prednisone and PUVA bath was initiated, with some improvement. This patient illustrates an example of ASIA (Autoimmune Syndrome Induced by Adjuvants), as her disease appeared following exposure to an adjuvant stimulus, with ‘typical’, although not well-defined, autoimmune manifestations.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22235043</pmid><doi>10.1177/0961203311429551</doi><tpages>4</tpages></addata></record> |
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| subjects | Abdomen Adjuvants, Immunologic - adverse effects Autoimmune diseases Autoimmune Diseases - chemically induced Autoimmune Diseases - immunology Biopsy Breast implants Breast Implants - adverse effects Chemical compounds Eosinophilia - etiology Eosinophilia - immunology Eosinophilia - pathology Fasciitis - etiology Fasciitis - immunology Fasciitis - pathology Female Humans Liposuction Lupus Medicine Middle Aged Middle East Scleroderma Scleroderma, Localized - etiology Scleroderma, Localized - immunology Scleroderma, Localized - pathology Silicones Silicones - adverse effects Skin diseases Surgical outcomes |
| title | Autoimmune Syndrome Induced by Adjuvants (ASIA) in the Middle East: morphea following silicone implantation |
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