Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206

J. Neurochem. (2012) 120, 230–238. Brain‐derived neurotrophic factor (BDNF) is required for efficient skeletal‐muscle regeneration and perturbing its expression causes abnormalities in the proliferation and differentiation of skeletal muscle cells. In this study, we investigated the mechanism of BDN...

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Veröffentlicht in:	Journal of neurochemistry 2012-01, Vol.120 (2), p.230-238
Hauptverfasser:	Miura, Pedro, Amirouche, Adel, Clow, Charlene, Bélanger, Guy, Jasmin, Bernard J
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - physiology alternative cleavage and polyadenylation Animals BDNF Biochemistry and metabolism Biological and medical sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell Differentiation - genetics Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell Line, Transformed Cell physiology Central nervous system Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay - methods Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Mice microRNA MicroRNAs - physiology miR-206 Molecular and cellular biology Muscle Development - physiology Musculoskeletal system Mutation - genetics Myoblasts - physiology myogenic differentiation Neurochemistry neuromuscular junction Neurons Receptor, Nerve Growth Factor - genetics Receptor, Nerve Growth Factor - metabolism RNA Isoforms - metabolism RNA, Messenger - metabolism Transfection Vertebrates: nervous system and sense organs
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