Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters

J. Neurochem. (2012) 120, 202–209. Recent evidence suggests that the persistence of cocaine seeking during periods of protracted drug abstinence following chronic cocaine exposure is mediated, in part, by neuroadaptations in the mesolimbic dopamine system. Specifically, incubation of cocaine‐seeking...

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Veröffentlicht in:	Journal of neurochemistry 2012-01, Vol.120 (2), p.202-209
Hauptverfasser:	Schmidt, Heath D., Sangrey, Gavin R., Darnell, Shayna B., Schassburger, Rachel L., Cha, Jang-Ho J., Pierce, R. Christopher, Sadri-Vakili, Ghazaleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects addiction Anesthetics, Local - administration & dosage Animals Biological and medical sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Chromatin Chromatin Immunoprecipitation chromatin remodeling Cocaine Cocaine - administration & dosage Cocaine-Related Disorders Conditioning, Operant - drug effects CREB-binding protein CREB-Binding Protein - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug abuse Drug addiction Drug addictions Drug self-administration Enzyme-Linked Immunosorbent Assay - methods epigenetics Exons Gene Expression Regulation - drug effects Histones Histones - metabolism Male Medical sciences Mesolimbic system Molecular modelling Neurochemistry Neurology neurotrophic factor Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - physiology Promoters psychostimulant Rats Rats, Sprague-Dawley Reinforcement Reinforcement Schedule RNA, Messenger - metabolism Self Administration Statistics, Nonparametric Substance Withdrawal Syndrome - metabolism Time Factors Toxicology Transcription Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Ventral tegmentum
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