Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque

It is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be a critical component of a successful vaccine against HIV. A significant fraction of HIV-infected individuals mount bNAb responses, providing support for the notion that such responses could be elicite...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-12, Vol.108 (50), p.20125-20129
Hauptverfasser:	Walker, Laura M, Sok, Devin, Nishimura, Yoshiaki, Donau, Olivia, Sadjadpour, Reza, Gautam, Rajeev, Shingai, Masashi, Pejchal, Robert, Ramos, Alejandra, Simek, Melissa D, Geng, Yu, Wilson, Ian A, Poignard, Pascal, Martin, Malcolm A, Burton, Dennis R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Specificity - immunology Antiviral agents Biological Sciences Carbohydrates Epitopes Evolution Glycoprotein gp120 HIV HIV - immunology HIV 1 HIV Envelope Protein gp120 - immunology HIV Infections - blood HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Immunization Immunoglobulins Infection Infections Inhibitory concentration 50 longitudinal studies Macaca Macaca - blood Macaca - immunology Macaca - virology Monkeys & apes mutants Mutation neutralization Neutralization Tests Neutralizing antibodies Polysaccharides Polysaccharides - immunology Protein Binding Recombination, Genetic - genetics Shivs Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Vaccination Vaccines Viruses
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