Cinnamon Extract Promotes Type I Collagen Biosynthesis via Activation of IGF-I Signaling in Human Dermal Fibroblasts

The breakdown of collagenous networks with aging results in hypoactive changes in the skin. Accordingly, reviving stagnant collagen synthesis can help protect dermal homeostasis against aging. We searched for type I collagen biosynthesis-inducing substances in various foods using human dermal fibrob...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2012-02, Vol.60 (5), p.1193-1200
Hauptverfasser:	Takasao, Naoko, Tsuji-Naito, Kentaro, Ishikura, Seiko, Tamura, Azusa, Akagawa, Mitsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aroma and flavouring agent industries Biological and medical sciences biosynthesis Cell Line Cinnamomum zeylanicum - chemistry cinnamon collagen Collagen Type I - biosynthesis Collagen Type I - genetics cytotoxicity fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Food industries foods Fundamental and applied biological sciences. Psychology gene expression regulation high performance liquid chromatography homeostasis Humans insulin insulin-like growth factor I Insulin-Like Growth Factor I - metabolism messenger RNA nuclear magnetic resonance spectroscopy phosphorylation Plant Extracts - isolation & purification Plant Extracts - pharmacology protein synthesis Signal Transduction - drug effects Skin - cytology Skin - metabolism
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