Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis

Objectives The primary human sinonasal epithelial cell culture (HSNEC) allows for in‐vitro modelling of mucosal responses to topical therapy. Cultures grown from healthy donors may underestimate changes in individuals with chronic sinonasal disease thereby yielding inaccurate results with respect t...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2012-03, Vol.64 (3), p.449-456
Hauptverfasser:	Bleier, Benjamin S., Mulligan, Ryan M., Schlosser, Rodney J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Case-Control Studies Cells, Cultured - drug effects Chronic Disease chronic rhinosinusitis Cilia - drug effects Dexamethasone - therapeutic use Dose-Response Relationship, Drug Epithelial Cells - drug effects Glucocorticoids - therapeutic use Humans in-vitro model Interleukin-6 - metabolism Interleukin-8 - metabolism Models, Biological Nasal Mucosa - drug effects nasal polyposis Nasal Polyps - drug therapy Nasal Polyps - genetics Phenotype primary human sinonasal epithelial cell culture Rhinitis - drug therapy Sinusitis - drug therapy Sinusitis - genetics topical drug delivery
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