Hypothyroidism reduces glutamate-synaptic release by ouabain depolarization in rat CA3-hippocampal region

Thyroid hormones modulate the physiology of the hippocampus in humans, where glutamate plays an important role as neurotransmitter. The aim of this work was to study the effect of hypothyroidism on hippocampal glutamate extracellular levels, release, uptake, and synthesis. The effects of PDC (a glut...

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Veröffentlicht in:	Journal of neuroscience research 2012-04, Vol.90 (4), p.905-912
Hauptverfasser:	Sánchez-Huerta, K.B., Montes, S., Pérez-Severiano, F., Alva-Sánchez, C., Ríos, C., Pacheco-Rosado, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antithyroid Agents - adverse effects Aspartic Acid - metabolism CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - metabolism Drug Interactions Enzyme Inhibitors - pharmacology glutamate toxicity Glutamate-Ammonia Ligase - metabolism Glutamic Acid - metabolism Glutaminase - metabolism Hypothyroidism - chemically induced Hypothyroidism - metabolism Male Methimazole - adverse effects Microdialysis neuronal damage Neurotransmitter Uptake Inhibitors - pharmacology Ouabain - pharmacology PDC Rats Rats, Wistar Synapses - drug effects thyroid hormones Thyroxine - blood Thyroxine - pharmacology TTX
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