Valproic acid: Growth inhibition of head and neck cancer by induction of terminal differentiation and senescence

Background There are limited studies on the effects of drugs that modulate epigenetic regulation for head and neck squamous cell carcinoma (HNSCC). This study determined the effect of valproic acid (VPA) on HNSCC. Methods Growth inhibition effects of VPA alone or in combination with 5‐aza‐2′deoxycyt...

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Veröffentlicht in:	Head & neck 2012-03, Vol.34 (3), p.344-353
Hauptverfasser:	Gan, Chai Phei, Hamid, Sharifah, Hor, Seen Yii, Zain, Rosnah Binti, Ismail, Siti Mazlipah, Wan Mustafa, Wan Mahadzir, Teo, Soo Hwang, Saunders, Nicholas, Cheong, Sok Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Azacitidine - analogs & derivatives Azacitidine - pharmacology Azacitidine - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cell Culture Techniques Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cellular Senescence - drug effects Decitabine head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology histone deacetylase inhibitor Histone Deacetylase Inhibitors - pharmacology Humans Medical sciences Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology senescence Squamous Cell Carcinoma of Head and Neck terminal differentiation Tretinoin - pharmacology Tretinoin - therapeutic use Tumors valproic acid Valproic Acid - pharmacology
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