Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study
Accurate staging of mediastinal lymph nodes metastases is critical for determining the application of stereotactic body radiation therapy (SBRT) for patients with early stage non-small cell lung cancer (NSCLC). In this multicenter study the accuracy of 18F-FDG PET/CT to detect lymph node metastases...
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| Veröffentlicht in: | Radiotherapy and oncology 2012-02, Vol.102 (2), p.246-250 |
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| creator | Li, Xiaolin Zhang, Huaqi Xing, Ligang Ma, Honglian Xie, Peng Zhang, Lin Xu, Xiangying Yue, Jinbo Sun, Xindong Hu, Xudong Chen, Ming Xu, Wengui Chen, Lusheng Yu, Jinming |
| description | Accurate staging of mediastinal lymph nodes metastases is critical for determining the application of stereotactic body radiation therapy (SBRT) for patients with early stage non-small cell lung cancer (NSCLC). In this multicenter study the accuracy of 18F-FDG PET/CT to detect lymph node metastases was evaluated for early stage NSCLC.
The data from the patients with stage1 NSCLC who received preoperative 18F-FDG PET/CT staging and radical surgery was retrospectively reviewed of five centers from February 2004 to August 2010. The lymph node metastases were confirmed histopathologically after radical surgery. And the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for PET/CT staging.
Two hundred patients were enrolled. The sensitivity, specificity, accuracy, PPV and NPV for lymph node metastases on PET/CT were 44%, 83%, 78%, 29% and 91%, respectively. There were eight and 19 cases positive for lymph node metastases with central (n=62) and peripheral (n=138) NSCLC (P>0.05), respectively.
18F-FDG PET/CT was specific in N0 staging for T1–2 NSCLC. The NPV was about 91% in clinical N0 patients, suggested that 18F-FDG PET/CT may help to accurately stage N0 patients and thus identify patients for SBRT. |
| doi_str_mv | 10.1016/j.radonc.2011.10.016 |
| format | Article |
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The data from the patients with stage1 NSCLC who received preoperative 18F-FDG PET/CT staging and radical surgery was retrospectively reviewed of five centers from February 2004 to August 2010. The lymph node metastases were confirmed histopathologically after radical surgery. And the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for PET/CT staging.
Two hundred patients were enrolled. The sensitivity, specificity, accuracy, PPV and NPV for lymph node metastases on PET/CT were 44%, 83%, 78%, 29% and 91%, respectively. There were eight and 19 cases positive for lymph node metastases with central (n=62) and peripheral (n=138) NSCLC (P>0.05), respectively.
18F-FDG PET/CT was specific in N0 staging for T1–2 NSCLC. The NPV was about 91% in clinical N0 patients, suggested that 18F-FDG PET/CT may help to accurately stage N0 patients and thus identify patients for SBRT.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2011.10.016</identifier><identifier>PMID: 22100657</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>18F-FDG PET/CT ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Lymph node ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Multimodal Imaging ; Neoplasm Staging ; NSCLC ; Positron-Emission Tomography ; Predictive Value of Tests ; Radiopharmaceuticals ; Retrospective Studies ; SBRT ; Sensitivity and Specificity ; Stage I ; Tomography, X-Ray Computed</subject><ispartof>Radiotherapy and oncology, 2012-02, Vol.102 (2), p.246-250</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2727-3d1ddcc0e2808e76c5808cd0e18d48781f4ffd856e3ad30993f9e8b1960ccd803</citedby><cites>FETCH-LOGICAL-c2727-3d1ddcc0e2808e76c5808cd0e18d48781f4ffd856e3ad30993f9e8b1960ccd803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.radonc.2011.10.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22100657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xiaolin</creatorcontrib><creatorcontrib>Zhang, Huaqi</creatorcontrib><creatorcontrib>Xing, Ligang</creatorcontrib><creatorcontrib>Ma, Honglian</creatorcontrib><creatorcontrib>Xie, Peng</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Xu, Xiangying</creatorcontrib><creatorcontrib>Yue, Jinbo</creatorcontrib><creatorcontrib>Sun, Xindong</creatorcontrib><creatorcontrib>Hu, Xudong</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Xu, Wengui</creatorcontrib><creatorcontrib>Chen, Lusheng</creatorcontrib><creatorcontrib>Yu, Jinming</creatorcontrib><title>Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Accurate staging of mediastinal lymph nodes metastases is critical for determining the application of stereotactic body radiation therapy (SBRT) for patients with early stage non-small cell lung cancer (NSCLC). In this multicenter study the accuracy of 18F-FDG PET/CT to detect lymph node metastases was evaluated for early stage NSCLC.
The data from the patients with stage1 NSCLC who received preoperative 18F-FDG PET/CT staging and radical surgery was retrospectively reviewed of five centers from February 2004 to August 2010. The lymph node metastases were confirmed histopathologically after radical surgery. And the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for PET/CT staging.
Two hundred patients were enrolled. The sensitivity, specificity, accuracy, PPV and NPV for lymph node metastases on PET/CT were 44%, 83%, 78%, 29% and 91%, respectively. There were eight and 19 cases positive for lymph node metastases with central (n=62) and peripheral (n=138) NSCLC (P>0.05), respectively.
18F-FDG PET/CT was specific in N0 staging for T1–2 NSCLC. The NPV was about 91% in clinical N0 patients, suggested that 18F-FDG PET/CT may help to accurately stage N0 patients and thus identify patients for SBRT.</description><subject>18F-FDG PET/CT</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Lymph node</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Neoplasm Staging</subject><subject>NSCLC</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>SBRT</subject><subject>Sensitivity and Specificity</subject><subject>Stage I</subject><subject>Tomography, X-Ray Computed</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBwh5xyplnKSxwwKpKhSQimBR1pZrT4qrPIqdIOXvcWlhycYjXZ3rsQ8hlwzGDFh2sxk7ZZpaj2NgLETjEB6RIRM8j0AIfkyGIeGRYCkMyJn3GwCIIeGnZBDHDCCb8CH5fEFjlW9trUpa9tX2g9aNQU99q9a2XtNVT5mYR_P7R_r2sLyZLWnROIrKlf0Pg4GvI1-psqQaw1F2oaVVrdHd0imturK1GusWXeA705-Tk0KVHi8Oc0Te5w_L2VO0eH18nk0XkY55zKPEMGO0BowFCOSZnoSpDSATJhVcsCItCiMmGSbKJJDnSZGjWLE8A62NgGRErvf3bl3z2aFvZWX97oWqxqbzMg8usjTLeSDTPald473DQm6drZTrJQO5cy03cu9a7lzv0hCG2tVhQbeq0PyVfuUG4G4PYPjml0UnvbYYxBjrULfSNPb_Dd-bc5D1</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Li, Xiaolin</creator><creator>Zhang, Huaqi</creator><creator>Xing, Ligang</creator><creator>Ma, Honglian</creator><creator>Xie, Peng</creator><creator>Zhang, Lin</creator><creator>Xu, Xiangying</creator><creator>Yue, Jinbo</creator><creator>Sun, Xindong</creator><creator>Hu, Xudong</creator><creator>Chen, Ming</creator><creator>Xu, Wengui</creator><creator>Chen, Lusheng</creator><creator>Yu, Jinming</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study</title><author>Li, Xiaolin ; Zhang, Huaqi ; Xing, Ligang ; Ma, Honglian ; Xie, Peng ; Zhang, Lin ; Xu, Xiangying ; Yue, Jinbo ; Sun, Xindong ; Hu, Xudong ; Chen, Ming ; Xu, Wengui ; Chen, Lusheng ; Yu, Jinming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2727-3d1ddcc0e2808e76c5808cd0e18d48781f4ffd856e3ad30993f9e8b1960ccd803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>18F-FDG PET/CT</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Lymph node</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Neoplasm Staging</topic><topic>NSCLC</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>SBRT</topic><topic>Sensitivity and Specificity</topic><topic>Stage I</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiaolin</creatorcontrib><creatorcontrib>Zhang, Huaqi</creatorcontrib><creatorcontrib>Xing, Ligang</creatorcontrib><creatorcontrib>Ma, Honglian</creatorcontrib><creatorcontrib>Xie, Peng</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Xu, Xiangying</creatorcontrib><creatorcontrib>Yue, Jinbo</creatorcontrib><creatorcontrib>Sun, Xindong</creatorcontrib><creatorcontrib>Hu, Xudong</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Xu, Wengui</creatorcontrib><creatorcontrib>Chen, Lusheng</creatorcontrib><creatorcontrib>Yu, Jinming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiaolin</au><au>Zhang, Huaqi</au><au>Xing, Ligang</au><au>Ma, Honglian</au><au>Xie, Peng</au><au>Zhang, Lin</au><au>Xu, Xiangying</au><au>Yue, Jinbo</au><au>Sun, Xindong</au><au>Hu, Xudong</au><au>Chen, Ming</au><au>Xu, Wengui</au><au>Chen, Lusheng</au><au>Yu, Jinming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>102</volume><issue>2</issue><spage>246</spage><epage>250</epage><pages>246-250</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Accurate staging of mediastinal lymph nodes metastases is critical for determining the application of stereotactic body radiation therapy (SBRT) for patients with early stage non-small cell lung cancer (NSCLC). In this multicenter study the accuracy of 18F-FDG PET/CT to detect lymph node metastases was evaluated for early stage NSCLC.
The data from the patients with stage1 NSCLC who received preoperative 18F-FDG PET/CT staging and radical surgery was retrospectively reviewed of five centers from February 2004 to August 2010. The lymph node metastases were confirmed histopathologically after radical surgery. And the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for PET/CT staging.
Two hundred patients were enrolled. The sensitivity, specificity, accuracy, PPV and NPV for lymph node metastases on PET/CT were 44%, 83%, 78%, 29% and 91%, respectively. There were eight and 19 cases positive for lymph node metastases with central (n=62) and peripheral (n=138) NSCLC (P>0.05), respectively.
18F-FDG PET/CT was specific in N0 staging for T1–2 NSCLC. The NPV was about 91% in clinical N0 patients, suggested that 18F-FDG PET/CT may help to accurately stage N0 patients and thus identify patients for SBRT.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22100657</pmid><doi>10.1016/j.radonc.2011.10.016</doi><tpages>5</tpages></addata></record> |
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| ispartof | Radiotherapy and oncology, 2012-02, Vol.102 (2), p.246-250 |
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| subjects | 18F-FDG PET/CT Adolescent Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Female Fluorodeoxyglucose F18 Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Lung Neoplasms - surgery Lymph node Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - pathology Male Middle Aged Multimodal Imaging Neoplasm Staging NSCLC Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Retrospective Studies SBRT Sensitivity and Specificity Stage I Tomography, X-Ray Computed |
| title | Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study |
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