Relationship between aggregation properties and antimicrobial activities of alkylphosphocholines with branched alkyl chains

Synthesis of five alkylphosphocholines with branched alkyl chains (Isophol-PCs) with different length of alkyl chains was described. Isophol8-PC and Isophol12-PC represent new compounds. The physico-chemical properties of Isophol-PCs were determined, critical micelle concentration and types of forme...

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Veröffentlicht in:	International journal of pharmaceutics 2012-02, Vol.423 (2), p.247-256
Hauptverfasser:	Lukáč, Miloš, Garajová, Mária, Mrva, Martin, Bukovský, Marián, Ondriska, František, Máriássy, Eszter, Devínsky, Ferdinand, Lacko, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthamoeba Acanthamoeba - drug effects Acanthamoeba - growth & development Acanthamoeba lugdunensis Acanthamoeba spp Alkylphosphocholines Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology anti-infective properties Antimicrobial activity aqueous solutions bacteria Candida albicans Candida albicans - drug effects Candida albicans - growth & development Critical micelle concentration Escherichia coli Escherichia coli - drug effects Escherichia coli - growth & development Micelles Microbial Sensitivity Tests Miltefosine Molecular Structure Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemical synthesis Phosphorylcholine - pharmacology Physicochemical properties Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Structure-Activity Relationship Time Factors Trophozoite yeasts
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