Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design
Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding c...
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| Veröffentlicht in: | American journal of epidemiology 2012-02, Vol.175 (4), p.315-324 |
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| creator | Aquino, Estela M. L. Barreto, Sandhi Maria Bensenor, Isabela M. Carvalho, Marilia S. Chor, Dóra Duncan, Bruce B. Lotufo, Paulo A. Mill, José Geraldo Molina, Maria Del Carmen Mota, Eduardo L. A. Azeredo Passos, Valéria Maria Schmidt, Maria Inês Szklo, Moyses |
| description | Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013. |
| doi_str_mv | 10.1093/aje/kwr294 |
| format | Article |
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L. ; Barreto, Sandhi Maria ; Bensenor, Isabela M. ; Carvalho, Marilia S. ; Chor, Dóra ; Duncan, Bruce B. ; Lotufo, Paulo A. ; Mill, José Geraldo ; Molina, Maria Del Carmen ; Mota, Eduardo L. A. ; Azeredo Passos, Valéria Maria ; Schmidt, Maria Inês ; Szklo, Moyses</creator><creatorcontrib>Aquino, Estela M. L. ; Barreto, Sandhi Maria ; Bensenor, Isabela M. ; Carvalho, Marilia S. ; Chor, Dóra ; Duncan, Bruce B. ; Lotufo, Paulo A. ; Mill, José Geraldo ; Molina, Maria Del Carmen ; Mota, Eduardo L. A. ; Azeredo Passos, Valéria Maria ; Schmidt, Maria Inês ; Szklo, Moyses</creatorcontrib><description>Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwr294</identifier><identifier>PMID: 22234482</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brazil - epidemiology ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Chronic Disease ; Developing Countries ; Diabetes ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - etiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiologic Research Design ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; General aspects ; Humans ; Incidence ; LDCs ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Obesity - diagnosis ; Obesity - epidemiology ; Obesity - etiology ; Occupational health ; Occupational medicine ; Patient Selection ; Population Surveillance ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk ; Sample Size ; Studies</subject><ispartof>American journal of epidemiology, 2012-02, Vol.175 (4), p.315-324</ispartof><rights>American Journal of Epidemiology © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Feb 15, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6b053728a252a6d14370cbcb0883fc37ec9de46ee1e541c2ce549eaf9faf66df3</citedby><cites>FETCH-LOGICAL-c442t-6b053728a252a6d14370cbcb0883fc37ec9de46ee1e541c2ce549eaf9faf66df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25557008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22234482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aquino, Estela M. L.</creatorcontrib><creatorcontrib>Barreto, Sandhi Maria</creatorcontrib><creatorcontrib>Bensenor, Isabela M.</creatorcontrib><creatorcontrib>Carvalho, Marilia S.</creatorcontrib><creatorcontrib>Chor, Dóra</creatorcontrib><creatorcontrib>Duncan, Bruce B.</creatorcontrib><creatorcontrib>Lotufo, Paulo A.</creatorcontrib><creatorcontrib>Mill, José Geraldo</creatorcontrib><creatorcontrib>Molina, Maria Del Carmen</creatorcontrib><creatorcontrib>Mota, Eduardo L. A.</creatorcontrib><creatorcontrib>Azeredo Passos, Valéria Maria</creatorcontrib><creatorcontrib>Schmidt, Maria Inês</creatorcontrib><creatorcontrib>Szklo, Moyses</creatorcontrib><title>Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Chronic Disease</subject><subject>Developing Countries</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiologic Research Design</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>LDCs</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Obesity - etiology</subject><subject>Occupational health</subject><subject>Occupational medicine</subject><subject>Patient Selection</subject><subject>Population Surveillance</subject><subject>Public health. Hygiene</subject><subject>Public health. 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The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. 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| subjects | Adult Aged Biological and medical sciences Brazil - epidemiology Cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Chronic Disease Developing Countries Diabetes Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiologic Research Design Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female General aspects Humans Incidence LDCs Longitudinal Studies Male Medical sciences Middle Aged Miscellaneous Obesity - diagnosis Obesity - epidemiology Obesity - etiology Occupational health Occupational medicine Patient Selection Population Surveillance Public health. Hygiene Public health. Hygiene-occupational medicine Risk Sample Size Studies |
| title | Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design |
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