Matrine Inhibits Disturbed Flow–Enhanced Migration via Downregulation of ERK1/2–MLCK Signaling Vascular Smooth Muscle Cells

Background To investigate the effects of matrine on the vascular smooth muscle cell (VSMC) migration modulated by disturbed flow and their underlying molecular mechanisms in vitro. Methods Isolated rat aortic VSMCs were grown to confluence on 20- × 80-mm fibronectin-coated glass cover slides, and th...

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Veröffentlicht in:	Annals of vascular surgery 2012-02, Vol.26 (2), p.268-275
Hauptverfasser:	Zhu, Ping, Chen, Ji-Mei, Guo, Hui-Ming, Fan, Xiao-Ping, Zhang, Xiao-Shen, Fan, Rui-Xin, Zheng, Shao-Yi, Wu, Ruo-Bin, Xiao, Xue-Jun, Huang, Huan-Lei, Zhu, Xiao-Lan, Liu, Huai-Pu, Long, Guang, Chen, Yan-Fang, Zhuang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Blotting, Western Cell Culture Techniques Cell Movement - drug effects Cells, Cultured Dose-Response Relationship, Drug Enzyme Activation Microscopy Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism Perfusion Phosphorylation Protein Kinase Inhibitors - pharmacology Quinolizines - pharmacology Rats Signal Transduction - drug effects Stress, Mechanical Surgery Time Factors
Online-Zugang:	Volltext
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