2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils

2-Aminoethoxydiphenyl borate (2-APB) interferes with the Ca2+ influx and reduces the ROS production, gelatinase secretion and CD11b expression in bovine neutrophils. Moreover, it has been suggested that inhibition of the Ca2+ channel involved in the store operated Ca2+ entry (SOCE) is a potential ta...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2012-01, Vol.145 (1-2), p.540-545
Hauptverfasser:	Conejeros, I., Velásquez, Z.D., Carretta, M.D., Alarcón, P., Hidalgo, M.A., Burgos, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-APB Actins - drug effects Actins - metabolism Alkaline Phosphatase - antagonists & inhibitors Alkaline Phosphatase - metabolism Animals Boron Compounds - pharmacology Bovine Calcium Calcium - metabolism Calcium Channel Blockers - pharmacology Cattle Chemotaxis - drug effects Chemotaxis - physiology Dose-Response Relationship, Drug Female Flow Cytometry - veterinary Neutrophils Neutrophils - drug effects Neutrophils - enzymology Neutrophils - metabolism Neutrophils - physiology Phagocytosis - drug effects Phagocytosis - physiology Platelet Activating Factor - pharmacology Polymerization - drug effects Tetraspanin 30 - biosynthesis
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