Downregulation of GABA(A) β subunits is transcriptionally controlled by Fmr1p

Fragile X mental retardation syndrome is caused by the transcriptional silence of FMR1. Here, a quantitative PCR technique was used to examine the effect of Fmr1p on the expression of GABA(A) β subunits in different mouse brain regions. Our results demonstrated the reduction of GABA(A) β2 mRNA in al...

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Veröffentlicht in:	Journal of molecular neuroscience 2012-02, Vol.46 (2), p.272-275
Hauptverfasser:	Hong, Andrew, Zhang, Aiying, Ke, Yang, El Idrissi, Abdeslem, Shen, Chang-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Congenic Brain - metabolism Cerebellum - metabolism Cerebral Cortex - metabolism Diencephalon - metabolism Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - physiology Hippocampus - metabolism Male Mice Mice, Knockout Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Organ Specificity Protein Subunits Real-Time Polymerase Chain Reaction Receptors, GABA-A - biosynthesis Receptors, GABA-A - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription, Genetic
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