A Multifunctional Nanocarrier Based on Nanogated Mesoporous Silica for Enhanced Tumor-Specific Uptake and Intracellular Delivery

A multifunctional drug delivery system based on MCM‐41‐type mesoporous silica nanoparticles is described that behaves as if nanogates were covalently attached to the outlets of the mesopores through a highly acid‐sensitive benzoic–imine linker. Tumor‐specific uptake and intracellular delivery result...

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Veröffentlicht in:	Macromolecular bioscience 2012-02, Vol.12 (2), p.251-259
Hauptverfasser:	Gao, Yaohua, Yang, Cuihong, Liu, Xue, Ma, Rujiang, Kong, Deling, Shi, Linqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Applied sciences Benzaldehydes - chemistry Benzoates - chemistry benzoic-imine Biological and medical sciences Cell Survival - drug effects Chemical modifications Chemical reactions and properties Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemical synthesis drug delivery systems Endocytosis - drug effects Endosomes - drug effects Endosomes - metabolism Exact sciences and technology Flow Cytometry General aspects Hep G2 Cells Humans Hydrogen-Ion Concentration Hydrolysis Imines - chemistry Medical sciences mesoporous silica multifunctional nanogated Nanoparticles - chemistry Organic polymers Pharmacology. Drug treatments Physicochemistry of polymers Polyethylene Glycols - chemistry Porosity Silicon Dioxide - chemistry
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