Natural and Engineered Plasmin Inhibitors: Applications and Design Strategies

The serine protease plasmin is ubiquitously expressed throughout the human body in the form of the zymogen plasminogen. Conversion to active plasmin occurs through enzymatic cleavage by plasminogen activators. The plasminogen activator/plasmin system has a well‐established function in the removal of...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2012-02, Vol.13 (3), p.336-348
Hauptverfasser:	Swedberg, Joakim E., Harris, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Fibrinolysin - antagonists & inhibitors Fibrinolysin - metabolism fibrinolysis Humans plasmin protease inhibitors Protein Engineering Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship substrate specificity
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