Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease

Several proteases like the high temperature requirement A (HtrA) protein family containing internal or C‐terminal PDZ domains play key roles in protein quality control in the cell envelope of Gram‐negative bacteria. While several HtrA proteases have been extensively characterized, many features of C...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2012-02, Vol.13 (3), p.402-408
Hauptverfasser:	Weski, Juliane, Meltzer, Michael, Spaan, Lina, Mönig, Timon, Oeljeklaus, Julian, Hauske, Patrick, Vouilleme, Lars, Volkmer, Rudolf, Boisguerin, Prisca, Boyd, Dana, Huber, Robert, Kaiser, Markus, Ehrmann, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Boronic Acids - chemistry chemical biology cooperativity Endopeptidases - chemistry Endopeptidases - metabolism inhibitors Ligands Molecular Structure PDZ Domains PDZ proteases Peptide Library Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Structure-Activity Relationship substrates
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