Effect of different preparation methods on the dissolution behaviour of amorphous indomethacin

Dissolution profiles of (a) cryo-milled and (b) differently cooled amorphous samples of indomethacin at 37±0.5°C. The aim of this study was to investigate whether amorphous indomethacin samples prepared using different preparative techniques and processing parameters exhibit different structural and...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2012-02, Vol.80 (2), p.459-464
Hauptverfasser:	Karmwar, Pranav, Graeser, Kirsten, Gordon, Keith C., Strachan, Clare J., Rades, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous Biological and medical sciences Chemistry, Pharmaceutical - methods Cooling rate Cryo-milling Crystallization Dissolution behaviour General pharmacology Indomethacin Indomethacin - chemistry Medical sciences Microscopy, Polarization Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Principal Component Analysis Solubility Solution-mediated solid state transformation Spectrum Analysis, Raman Time Factors X-Ray Diffraction
Online-Zugang:	Volltext
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