Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients
Abstract Background Benzodiazepine (BZD) misuse in opioid-maintained patients is widespread and has been related to poorer treatment success. Associated factors, in particular, traumatic childhood experiences, have not been investigated extensively. Methods Cross-sectional survey including the child...
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| Veröffentlicht in: | Drug and alcohol dependence 2011-12, Vol.119 (1), p.93-98 |
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| creator | Vogel, Marc Dürsteler-MacFarland, Kenneth M Walter, Marc Strasser, Johannes Fehr, Stephanie Prieto, Luis Wiesbeck, Gerhard A |
| description | Abstract Background Benzodiazepine (BZD) misuse in opioid-maintained patients is widespread and has been related to poorer treatment success. Associated factors, in particular, traumatic childhood experiences, have not been investigated extensively. Methods Cross-sectional survey including the childhood trauma questionnaire (CTQ) and clinical data among 193 patients prescribed oral opioids or injectable diacetylmorphine for opioid dependence. Results BZD use was prevalent (61%) and the burden of childhood traumatic experiences was high with 67% reporting at least one trauma subscore of moderate-to-severe level. In univariate analysis, CTQ-subcategories “emotional abuse” ( p < 0.05), “emotional neglect” ( p < 0.01) and “physical neglect” ( p < 0.001) were significantly associated with prolonged BZD use. In multivariate analysis, prolonged BZD use was associated with categorized overall CTQ-scores (OR 1.5), HCV-seropositivity (OR 4.0), psychiatric family history (OR 2.3), and opioid dose (mg methadone equivalents, OR 1.010). Conclusions Childhood traumatic experiences may be associated with prolonged BZD use in opioid-maintained patients and could pose an important starting-point for prevention. |
| doi_str_mv | 10.1016/j.drugalcdep.2011.05.037 |
| format | Article |
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Associated factors, in particular, traumatic childhood experiences, have not been investigated extensively. Methods Cross-sectional survey including the childhood trauma questionnaire (CTQ) and clinical data among 193 patients prescribed oral opioids or injectable diacetylmorphine for opioid dependence. Results BZD use was prevalent (61%) and the burden of childhood traumatic experiences was high with 67% reporting at least one trauma subscore of moderate-to-severe level. In univariate analysis, CTQ-subcategories “emotional abuse” ( p < 0.05), “emotional neglect” ( p < 0.01) and “physical neglect” ( p < 0.001) were significantly associated with prolonged BZD use. In multivariate analysis, prolonged BZD use was associated with categorized overall CTQ-scores (OR 1.5), HCV-seropositivity (OR 4.0), psychiatric family history (OR 2.3), and opioid dose (mg methadone equivalents, OR 1.010). Conclusions Childhood traumatic experiences may be associated with prolonged BZD use in opioid-maintained patients and could pose an important starting-point for prevention.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2011.05.037</identifier><identifier>PMID: 21715105</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Adverse childhood events ; Age Factors ; Analgesics, Opioid - adverse effects ; Analgesics, Opioid - therapeutic use ; Analgesics, Opioid - urine ; Benzodiazepines ; Benzodiazepines - adverse effects ; Benzodiazepines - therapeutic use ; Benzodiazepines - urine ; Biological and medical sciences ; Child ; Child Abuse - psychology ; Child Abuse - statistics & numerical data ; Childhood ; Childhood abuse ; Comorbidity ; Cross-Sectional Studies ; Diazepam ; Drug addiction ; Female ; Humans ; Logistic Models ; Male ; Medical sciences ; Methadone - therapeutic use ; Methadone - urine ; Neuropharmacology ; Opiate Substitution Treatment - methods ; Opiate Substitution Treatment - psychology ; Opiate Substitution Treatment - statistics & numerical data ; Opioid dependence ; Opioid-Related Disorders - drug therapy ; Opioid-Related Disorders - epidemiology ; Opioid-Related Disorders - psychology ; Opioids ; Pharmacology. Drug treatments ; Prescribed ; Psychiatric Status Rating Scales ; Psychiatry ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Sedative ; Substance-Related Disorders - drug therapy ; Substance-Related Disorders - epidemiology ; Substance-Related Disorders - psychology ; Surveys and Questionnaires ; Time Factors ; Traumatic life events ; Violence</subject><ispartof>Drug and alcohol dependence, 2011-12, Vol.119 (1), p.93-98</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-c83cf643dfc90454f95256e04b9c3bde85b58184921a28406ca683866af415083</citedby><cites>FETCH-LOGICAL-c523t-c83cf643dfc90454f95256e04b9c3bde85b58184921a28406ca683866af415083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drugalcdep.2011.05.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24712617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21715105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogel, Marc</creatorcontrib><creatorcontrib>Dürsteler-MacFarland, Kenneth M</creatorcontrib><creatorcontrib>Walter, Marc</creatorcontrib><creatorcontrib>Strasser, Johannes</creatorcontrib><creatorcontrib>Fehr, Stephanie</creatorcontrib><creatorcontrib>Prieto, Luis</creatorcontrib><creatorcontrib>Wiesbeck, Gerhard A</creatorcontrib><title>Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Abstract Background Benzodiazepine (BZD) misuse in opioid-maintained patients is widespread and has been related to poorer treatment success. Associated factors, in particular, traumatic childhood experiences, have not been investigated extensively. Methods Cross-sectional survey including the childhood trauma questionnaire (CTQ) and clinical data among 193 patients prescribed oral opioids or injectable diacetylmorphine for opioid dependence. Results BZD use was prevalent (61%) and the burden of childhood traumatic experiences was high with 67% reporting at least one trauma subscore of moderate-to-severe level. In univariate analysis, CTQ-subcategories “emotional abuse” ( p < 0.05), “emotional neglect” ( p < 0.01) and “physical neglect” ( p < 0.001) were significantly associated with prolonged BZD use. In multivariate analysis, prolonged BZD use was associated with categorized overall CTQ-scores (OR 1.5), HCV-seropositivity (OR 4.0), psychiatric family history (OR 2.3), and opioid dose (mg methadone equivalents, OR 1.010). Conclusions Childhood traumatic experiences may be associated with prolonged BZD use in opioid-maintained patients and could pose an important starting-point for prevention.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Adverse childhood events</subject><subject>Age Factors</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Analgesics, Opioid - urine</subject><subject>Benzodiazepines</subject><subject>Benzodiazepines - adverse effects</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Benzodiazepines - urine</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Abuse - psychology</subject><subject>Child Abuse - statistics & numerical data</subject><subject>Childhood</subject><subject>Childhood abuse</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Diazepam</subject><subject>Drug addiction</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methadone - therapeutic use</subject><subject>Methadone - urine</subject><subject>Neuropharmacology</subject><subject>Opiate Substitution Treatment - methods</subject><subject>Opiate Substitution Treatment - psychology</subject><subject>Opiate Substitution Treatment - statistics & numerical data</subject><subject>Opioid dependence</subject><subject>Opioid-Related Disorders - drug therapy</subject><subject>Opioid-Related Disorders - epidemiology</subject><subject>Opioid-Related Disorders - psychology</subject><subject>Opioids</subject><subject>Pharmacology. Drug treatments</subject><subject>Prescribed</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Sedative</subject><subject>Substance-Related Disorders - drug therapy</subject><subject>Substance-Related Disorders - epidemiology</subject><subject>Substance-Related Disorders - psychology</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><subject>Traumatic life events</subject><subject>Violence</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkt-L1DAQgIMo3t7qvyB9EX3pOpM2afoi6OGpcKCgPoc0md5m7TY1aZW7v94su3rggxoIgfDND-YbxgqEDQLKF7uNi8u1GayjacMBcQNiA1Vzj61QNW0JUMv7bJV_ZKkalGfsPKUd5CNbeMjOODYoEMSKdR9jGMJ4Ta5YEhWhLzoab4Pz5pYmP1IqfCpMSsF6M2foh5-3hd36wW1DcMUczbI3hR-LMPngXbk3fpzzzehkZk_jnB6xB70ZEj0-vWv25fLN54t35dWHt-8vXl2VVvBqLq2qbC_ryvW2hVrUfSu4kAR119qqc6REJxSquuVouKpBWiNVpaQ0fY0CVLVmz455pxi-LZRmvffJ0jCYkcKSdItt22AO-TcJWEGjcltr9vyvJFaCc8VB1BlVR9TGkFKkXk_R70280Qj6YE3v9J01fbCmQejsKIc-OVVZuj2534G_NGXg6QkwyZqhj2a0Pt1xdYNc4iHR6yNHec7fPUWdbHZgyflIdtYu-P_p5uUfSezgR5_rfqUbSruwxDF71KgT16A_HbbssGSIAFzm8f4Er-LPHg</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Vogel, Marc</creator><creator>Dürsteler-MacFarland, Kenneth M</creator><creator>Walter, Marc</creator><creator>Strasser, Johannes</creator><creator>Fehr, Stephanie</creator><creator>Prieto, Luis</creator><creator>Wiesbeck, Gerhard A</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>7QJ</scope></search><sort><creationdate>20111201</creationdate><title>Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients</title><author>Vogel, Marc ; Dürsteler-MacFarland, Kenneth M ; Walter, Marc ; Strasser, Johannes ; Fehr, Stephanie ; Prieto, Luis ; Wiesbeck, Gerhard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-c83cf643dfc90454f95256e04b9c3bde85b58184921a28406ca683866af415083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Adverse childhood events</topic><topic>Age Factors</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Analgesics, Opioid - urine</topic><topic>Benzodiazepines</topic><topic>Benzodiazepines - adverse effects</topic><topic>Benzodiazepines - therapeutic use</topic><topic>Benzodiazepines - urine</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Abuse - psychology</topic><topic>Child Abuse - statistics & numerical data</topic><topic>Childhood</topic><topic>Childhood abuse</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Diazepam</topic><topic>Drug addiction</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methadone - therapeutic use</topic><topic>Methadone - urine</topic><topic>Neuropharmacology</topic><topic>Opiate Substitution Treatment - methods</topic><topic>Opiate Substitution Treatment - psychology</topic><topic>Opiate Substitution Treatment - statistics & numerical data</topic><topic>Opioid dependence</topic><topic>Opioid-Related Disorders - drug therapy</topic><topic>Opioid-Related Disorders - epidemiology</topic><topic>Opioid-Related Disorders - psychology</topic><topic>Opioids</topic><topic>Pharmacology. Drug treatments</topic><topic>Prescribed</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Sedative</topic><topic>Substance-Related Disorders - drug therapy</topic><topic>Substance-Related Disorders - epidemiology</topic><topic>Substance-Related Disorders - psychology</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><topic>Traumatic life events</topic><topic>Violence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogel, Marc</creatorcontrib><creatorcontrib>Dürsteler-MacFarland, Kenneth M</creatorcontrib><creatorcontrib>Walter, Marc</creatorcontrib><creatorcontrib>Strasser, Johannes</creatorcontrib><creatorcontrib>Fehr, Stephanie</creatorcontrib><creatorcontrib>Prieto, Luis</creatorcontrib><creatorcontrib>Wiesbeck, Gerhard A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogel, Marc</au><au>Dürsteler-MacFarland, Kenneth M</au><au>Walter, Marc</au><au>Strasser, Johannes</au><au>Fehr, Stephanie</au><au>Prieto, Luis</au><au>Wiesbeck, Gerhard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>119</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Abstract Background Benzodiazepine (BZD) misuse in opioid-maintained patients is widespread and has been related to poorer treatment success. Associated factors, in particular, traumatic childhood experiences, have not been investigated extensively. Methods Cross-sectional survey including the childhood trauma questionnaire (CTQ) and clinical data among 193 patients prescribed oral opioids or injectable diacetylmorphine for opioid dependence. Results BZD use was prevalent (61%) and the burden of childhood traumatic experiences was high with 67% reporting at least one trauma subscore of moderate-to-severe level. In univariate analysis, CTQ-subcategories “emotional abuse” ( p < 0.05), “emotional neglect” ( p < 0.01) and “physical neglect” ( p < 0.001) were significantly associated with prolonged BZD use. In multivariate analysis, prolonged BZD use was associated with categorized overall CTQ-scores (OR 1.5), HCV-seropositivity (OR 4.0), psychiatric family history (OR 2.3), and opioid dose (mg methadone equivalents, OR 1.010). Conclusions Childhood traumatic experiences may be associated with prolonged BZD use in opioid-maintained patients and could pose an important starting-point for prevention.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21715105</pmid><doi>10.1016/j.drugalcdep.2011.05.037</doi><tpages>6</tpages></addata></record> |
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| ispartof | Drug and alcohol dependence, 2011-12, Vol.119 (1), p.93-98 |
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| subjects | Addictive behaviors Adult and adolescent clinical studies Adverse childhood events Age Factors Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Analgesics, Opioid - urine Benzodiazepines Benzodiazepines - adverse effects Benzodiazepines - therapeutic use Benzodiazepines - urine Biological and medical sciences Child Child Abuse - psychology Child Abuse - statistics & numerical data Childhood Childhood abuse Comorbidity Cross-Sectional Studies Diazepam Drug addiction Female Humans Logistic Models Male Medical sciences Methadone - therapeutic use Methadone - urine Neuropharmacology Opiate Substitution Treatment - methods Opiate Substitution Treatment - psychology Opiate Substitution Treatment - statistics & numerical data Opioid dependence Opioid-Related Disorders - drug therapy Opioid-Related Disorders - epidemiology Opioid-Related Disorders - psychology Opioids Pharmacology. Drug treatments Prescribed Psychiatric Status Rating Scales Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Sedative Substance-Related Disorders - drug therapy Substance-Related Disorders - epidemiology Substance-Related Disorders - psychology Surveys and Questionnaires Time Factors Traumatic life events Violence |
| title | Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients |
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