Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender
We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone spee...
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| Veröffentlicht in: | Molecular biology reports 2012-03, Vol.39 (3), p.2259-2265 |
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| description | We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) values were measured at distal radius or mid-shaft tibia by quantitative ultrasound. Genotypic associations of SOS were tested with each of nucleotide sequence variants identified by previous studies. The genetic association analysis revealed that 2 out of 11 nucleotide sequence variants were associated with SOS (rs1721400, rs7776725,
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| doi_str_mv | 10.1007/s11033-011-0975-z |
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P
< 7.58 × 10
−4
). Further analysis with partitioning data by gender showed that the mid-shaft tibia phenotypes were associated with the rs1721400 and rs7776725 in females (
P
< 3.79 × 10
−4
), but not in males (
P
> 3.79 × 10
−4
). The current study suggested female-specific associations of rs1721400 and rs7776725 with bone mineral density and heterogeneity of genetic association by skeletal site measured for bone mineral density.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-0975-z</identifier><identifier>PMID: 21655950</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Association analysis ; Biomedical and Life Sciences ; Bone density ; Bone Density - genetics ; Bone mineral density ; Cohort Studies ; Data processing ; Female ; Gender ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease - genetics ; Genetics ; Genotype ; Histology ; Humans ; Life Sciences ; Male ; Middle Aged ; Morphology ; Nucleotide sequence ; Osteoporosis - epidemiology ; Osteoporosis - genetics ; Phenotype ; Polymorphism, Single Nucleotide - genetics ; Radius ; Radius - diagnostic imaging ; Republic of Korea - epidemiology ; Sex Factors ; Tibia ; Tibia - diagnostic imaging ; Ultrasonography ; Ultrasound</subject><ispartof>Molecular biology reports, 2012-03, Vol.39 (3), p.2259-2265</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-bd2eb43765a1d7799fd2e97e2d3429a1fda8379d4375d5356564144066bb22f3</citedby><cites>FETCH-LOGICAL-c403t-bd2eb43765a1d7799fd2e97e2d3429a1fda8379d4375d5356564144066bb22f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-0975-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-0975-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21655950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woo, Jiyoung</creatorcontrib><creatorcontrib>Kim, Younyoung</creatorcontrib><creatorcontrib>Lee, Chaeyoung</creatorcontrib><title>Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) values were measured at distal radius or mid-shaft tibia by quantitative ultrasound. Genotypic associations of SOS were tested with each of nucleotide sequence variants identified by previous studies. The genetic association analysis revealed that 2 out of 11 nucleotide sequence variants were associated with SOS (rs1721400, rs7776725,
P
< 7.58 × 10
−4
). Further analysis with partitioning data by gender showed that the mid-shaft tibia phenotypes were associated with the rs1721400 and rs7776725 in females (
P
< 3.79 × 10
−4
), but not in males (
P
> 3.79 × 10
−4
). The current study suggested female-specific associations of rs1721400 and rs7776725 with bone mineral density and heterogeneity of genetic association by skeletal site measured for bone mineral density.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Association analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Bone density</subject><subject>Bone Density - genetics</subject><subject>Bone mineral density</subject><subject>Cohort Studies</subject><subject>Data processing</subject><subject>Female</subject><subject>Gender</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Nucleotide sequence</subject><subject>Osteoporosis - epidemiology</subject><subject>Osteoporosis - genetics</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Radius</subject><subject>Radius - diagnostic imaging</subject><subject>Republic of Korea - epidemiology</subject><subject>Sex Factors</subject><subject>Tibia</subject><subject>Tibia - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1v1DAQhi0EotuFH8AFWVzoJeDxRxwfUUVbpEpceo-ceFJcZe3Wdlptfz0OW6iEBKeRxs88ntFLyDtgn4Ax_TkDMCEaBtAwo1Xz-IJsQGnRSKO7l2TDBINGdgqOyHHON4wxCVq9JkccWqWMYhsyXWDBFK8xYFwyXWvxI7U5x9Hb4mPINE40LOOMsXiHNOPdgmFEem-Tt6Fk-uDLDzrEgHTnAyY7U4ch-7Knw341OkxvyKvJzhnfPtUtuTr7enV60Vx-P_92-uWyGSUTpRkcx0EK3SoLTmtjptowGrkTkhsLk7Od0MZVRDklVKtaCVKyth0GziexJR8P2tsU65a59DufR5xn--u83oAxSkswlTz5LwmMd4xLXtfakg9_oTdxSaGesfraTjLVVggO0Jhizgmn_jb5nU37aurXsPpDWH0Nq1_D6h_rzPsn8TLs0P2Z-J1OBfgByPUpXGN6_vnf1p9oEJ_9</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Woo, Jiyoung</creator><creator>Kim, Younyoung</creator><creator>Lee, Chaeyoung</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender</title><author>Woo, Jiyoung ; Kim, Younyoung ; Lee, Chaeyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-bd2eb43765a1d7799fd2e97e2d3429a1fda8379d4375d5356564144066bb22f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Association analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Bone density</topic><topic>Bone Density - genetics</topic><topic>Bone mineral density</topic><topic>Cohort Studies</topic><topic>Data processing</topic><topic>Female</topic><topic>Gender</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Histology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Nucleotide sequence</topic><topic>Osteoporosis - epidemiology</topic><topic>Osteoporosis - genetics</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Radius</topic><topic>Radius - diagnostic imaging</topic><topic>Republic of Korea - epidemiology</topic><topic>Sex Factors</topic><topic>Tibia</topic><topic>Tibia - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woo, Jiyoung</creatorcontrib><creatorcontrib>Kim, Younyoung</creatorcontrib><creatorcontrib>Lee, Chaeyoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woo, Jiyoung</au><au>Kim, Younyoung</au><au>Lee, Chaeyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>39</volume><issue>3</issue><spage>2259</spage><epage>2265</epage><pages>2259-2265</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) values were measured at distal radius or mid-shaft tibia by quantitative ultrasound. Genotypic associations of SOS were tested with each of nucleotide sequence variants identified by previous studies. The genetic association analysis revealed that 2 out of 11 nucleotide sequence variants were associated with SOS (rs1721400, rs7776725,
P
< 7.58 × 10
−4
). Further analysis with partitioning data by gender showed that the mid-shaft tibia phenotypes were associated with the rs1721400 and rs7776725 in females (
P
< 3.79 × 10
−4
), but not in males (
P
> 3.79 × 10
−4
). The current study suggested female-specific associations of rs1721400 and rs7776725 with bone mineral density and heterogeneity of genetic association by skeletal site measured for bone mineral density.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21655950</pmid><doi>10.1007/s11033-011-0975-z</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Online Journals |
| subjects | Animal Anatomy Animal Biochemistry Association analysis Biomedical and Life Sciences Bone density Bone Density - genetics Bone mineral density Cohort Studies Data processing Female Gender Gene Frequency Genetic Association Studies Genetic Predisposition to Disease - genetics Genetics Genotype Histology Humans Life Sciences Male Middle Aged Morphology Nucleotide sequence Osteoporosis - epidemiology Osteoporosis - genetics Phenotype Polymorphism, Single Nucleotide - genetics Radius Radius - diagnostic imaging Republic of Korea - epidemiology Sex Factors Tibia Tibia - diagnostic imaging Ultrasonography Ultrasound |
| title | Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender |
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