Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides

Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of Systemic Lupus Erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the...

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Veröffentlicht in:	Journal of immunotoxicology 2012-01, Vol.9 (1), p.85-95
Hauptverfasser:	Dar, Sajad A., Das, Shukla, Ramachandran, Vishnampettai G., Bhattacharya, Sambit N., Mustafa, M. D., Banerjee, Basu D., Verma, Prashant
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Cells, Cultured Chromatography, Gas cytokines Cytokines - secretion DDT DDT - toxicity Enzyme-Linked Immunosorbent Assay Female Flow Cytometry HCH Humans Hydrocarbons, Chlorinated - blood Hydrocarbons, Chlorinated - toxicity India Interferon-gamma - secretion Interleukin-10 - secretion Interleukin-2 - secretion Interleukin-4 - secretion Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - secretion Lindane - toxicity Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - immunology Male Mitogens - pharmacology OCP Pesticides - blood Pesticides - toxicity Phytohemagglutinins - pharmacology SLE systemic lupus erythematosus T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - secretion T-lymphocytes Time Factors Toxicity Tests Young Adult
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