Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?

The airway smooth muscle (ASM) layer within the airway wall modulates airway diameter and distensibility. Even in the relaxed state, the ASM layer possesses finite stiffness and limits the extent of airway distension by the radial force generated by parenchymal tethers and transmural pressure. Airwa...

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Veröffentlicht in:	Journal of applied physiology (1985) 2012-02, Vol.112 (3), p.337-346
Hauptverfasser:	Raqeeb, Abdul, Jiao, Yuekan, Syyong, Harley T, Paré, Peter D, Seow, Chun Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Amides - pharmacology Animals Asthma Asthma - drug therapy Asthma - metabolism Asthma - physiopathology Azepines - pharmacology Calcium - metabolism Imidazoles - pharmacology In Vitro Techniques Kinases Molecular Targeted Therapy Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiology Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism Naphthalenes - pharmacology Phosphorylation Physiology Pyridines - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Sheep Signal Transduction Smooth muscle Trachea - drug effects Trachea - metabolism Trachea - physiology
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