Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma

This study explored the combined effect of number and pattern of mutations in the X/precore regions of the hepatitis B virus (HBV) genome, mutational complex genotype (MCG), on hepatocellular carcinoma (HCC) development. Sequence variations were determined by direct sequencing and multiplex restrict...

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Veröffentlicht in:	Cancer science 2012-02, Vol.103 (2), p.296-304
Hauptverfasser:	Jang, Jeong Won, Chun, Ji‐Yong, Park, Young Min, Shin, Soo‐Kyung, Yoo, Wangdon, Kim, Soo‐Ok, Hong, Sun Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged alpha -fetoprotein Base Sequence Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - virology Case-Control Studies DNA, Viral - genetics Female Gene polymorphism Genetic Markers Genome, Viral Genomes Genotype Genotype & phenotype Hepatitis B Hepatitis B - complications Hepatitis B - virology Hepatitis B Core Antigens - genetics Hepatitis B e antigen Hepatitis B e Antigens - genetics Hepatitis B virus Hepatitis B virus - genetics Hepatocellular carcinoma Humans Infections Laboratories Liver cancer Liver cirrhosis Liver diseases Liver Neoplasms - complications Liver Neoplasms - virology Male Middle Aged Multivariate analysis Mutation Nucleotide sequence Patients Polymorphism, Single Nucleotide Risk factors Risk groups Sequence Analysis, DNA Trans-Activators - genetics
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