Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population
Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine recep...
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| Veröffentlicht in: | Molecular biology reports 2012-03, Vol.39 (3), p.2753-2759 |
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| creator | Singh, Neha Sinha, Nakul Kumar, Sudeep Pandey, Chandra M. Agrawal, Suraksha |
| description | Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356,
P
= 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09,
P
= 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66,
P
|
| doi_str_mv | 10.1007/s11033-011-1031-8 |
| format | Article |
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P
= 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09,
P
= 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66,
P
< 0.0001 and OR 0.36, CI 0.24–0.55,
P
< 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors, i.e., CCR5 and CX3CR1.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1031-8</identifier><identifier>PMID: 21744265</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; CCR5 protein ; Chemokine receptors ; Chemokines ; CX3C Chemokine Receptor 1 ; CX3CR1 protein ; DNA Mutational Analysis ; DNA Primers - genetics ; Gene Frequency ; Gene polymorphism ; Genes ; Genetic Association Studies ; Genetic diversity ; Genetic Predisposition to Disease - genetics ; Heart ; Heart attacks ; Histology ; Humans ; India - epidemiology ; Inflammation ; Insertion ; Leukocyte migration ; Leukocytes ; Life Sciences ; Morphology ; Myocardial infarction ; Myocardial Infarction - epidemiology ; Myocardial Infarction - genetics ; Neurons ; Odds Ratio ; Polymorphism ; Polymorphism, Genetic - genetics ; Receptors, CCR5 - genetics ; Receptors, Chemokine - genetics ; Risk Factors</subject><ispartof>Molecular biology reports, 2012-03, Vol.39 (3), p.2753-2759</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-856e6dc7356b975a80927b77dae802e73ed3bc333dd1576c8e58090d3ded57903</citedby><cites>FETCH-LOGICAL-c469t-856e6dc7356b975a80927b77dae802e73ed3bc333dd1576c8e58090d3ded57903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1031-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1031-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21744265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Neha</creatorcontrib><creatorcontrib>Sinha, Nakul</creatorcontrib><creatorcontrib>Kumar, Sudeep</creatorcontrib><creatorcontrib>Pandey, Chandra M.</creatorcontrib><creatorcontrib>Agrawal, Suraksha</creatorcontrib><title>Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356,
P
= 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09,
P
= 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66,
P
< 0.0001 and OR 0.36, CI 0.24–0.55,
P
< 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors, i.e., CCR5 and CX3CR1.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>CCR5 protein</subject><subject>Chemokine receptors</subject><subject>Chemokines</subject><subject>CX3C Chemokine Receptor 1</subject><subject>CX3CR1 protein</subject><subject>DNA Mutational Analysis</subject><subject>DNA Primers - genetics</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Histology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Inflammation</subject><subject>Insertion</subject><subject>Leukocyte migration</subject><subject>Leukocytes</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - genetics</subject><subject>Neurons</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Receptors, CCR5 - genetics</subject><subject>Receptors, Chemokine - genetics</subject><subject>Risk Factors</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1PxCAURYnR6PjxA9wY4kY3VSilwNIYvxKjLnTdMPBmpk4LFdrF_HtpZtTERFeQvHMPeVyEjim5oISIy0gpYSwjlGbpQjO5hSaUC5YVSshtNCGM0KyQnO6h_RjfCSEFFXwX7eVUFEVe8glavvhm1frQLerY4tphs4DWL2sHOICBrvcBz8FBxNpZHOq4xH6GtRl6wO3KGx1srZsUnOlg-tq70fHkQ7_ADy6NHO58NzR6HB2inZluIhxtzgP0dnvzen2fPT7fPVxfPWamKFWfSV5CaY1gvJwqwbUkKhdTIawGSXIQDCybGsaYtWnZ0kjgCSGWWbBcKMIO0Nna2wX_MUDsq7aOBppGO_BDrBRVinOmWCLP_yXTL0vJaC6LhJ7-Qt_9EFzaY_SVsqB5mSC6hkzwMQaYVV2oWx1WyTTKRLWurEqVVWNllUyZk414mLZgvxNfHSUgXwMxjdwcws_Lf1s_AWndoQ8</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Singh, Neha</creator><creator>Sinha, Nakul</creator><creator>Kumar, Sudeep</creator><creator>Pandey, Chandra M.</creator><creator>Agrawal, Suraksha</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population</title><author>Singh, Neha ; Sinha, Nakul ; Kumar, Sudeep ; Pandey, Chandra M. ; Agrawal, Suraksha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-856e6dc7356b975a80927b77dae802e73ed3bc333dd1576c8e58090d3ded57903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>CCR5 protein</topic><topic>Chemokine receptors</topic><topic>Chemokines</topic><topic>CX3C Chemokine Receptor 1</topic><topic>CX3CR1 protein</topic><topic>DNA Mutational Analysis</topic><topic>DNA Primers - genetics</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic Association Studies</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Histology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Inflammation</topic><topic>Insertion</topic><topic>Leukocyte migration</topic><topic>Leukocytes</topic><topic>Life Sciences</topic><topic>Morphology</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - genetics</topic><topic>Neurons</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Receptors, CCR5 - genetics</topic><topic>Receptors, Chemokine - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Neha</creatorcontrib><creatorcontrib>Sinha, Nakul</creatorcontrib><creatorcontrib>Kumar, Sudeep</creatorcontrib><creatorcontrib>Pandey, Chandra M.</creatorcontrib><creatorcontrib>Agrawal, Suraksha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Neha</au><au>Sinha, Nakul</au><au>Kumar, Sudeep</au><au>Pandey, Chandra M.</au><au>Agrawal, Suraksha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>39</volume><issue>3</issue><spage>2753</spage><epage>2759</epage><pages>2753-2759</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356,
P
= 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09,
P
= 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66,
P
< 0.0001 and OR 0.36, CI 0.24–0.55,
P
< 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors, i.e., CCR5 and CX3CR1.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21744265</pmid><doi>10.1007/s11033-011-1031-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences CCR5 protein Chemokine receptors Chemokines CX3C Chemokine Receptor 1 CX3CR1 protein DNA Mutational Analysis DNA Primers - genetics Gene Frequency Gene polymorphism Genes Genetic Association Studies Genetic diversity Genetic Predisposition to Disease - genetics Heart Heart attacks Histology Humans India - epidemiology Inflammation Insertion Leukocyte migration Leukocytes Life Sciences Morphology Myocardial infarction Myocardial Infarction - epidemiology Myocardial Infarction - genetics Neurons Odds Ratio Polymorphism Polymorphism, Genetic - genetics Receptors, CCR5 - genetics Receptors, Chemokine - genetics Risk Factors |
| title | Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population |
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