DJ-1 may contribute to metastasis of non-small cell lung cancer
Lung cancer is a leading cause of cancer-related death, about 40% human non-small cell lung cancer (NSCLC) patients showed lymph node involvements. However, the precise mechanism for the metastasis is still not fully understood. This study was to analyze the potential molecular mechanism for lung ca...
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| Veröffentlicht in: | Molecular biology reports 2012-03, Vol.39 (3), p.2697-2703 |
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| creator | Bai, Jing Guo, Changlong Sun, Wenjing Li, Ming Meng, Xiangning Yu, Yang Jin, Yan Tong, Dandan Geng, Jingshu Huang, Qi Qi, Jiping Fu, Songbin |
| description | Lung cancer is a leading cause of cancer-related death, about 40% human non-small cell lung cancer (NSCLC) patients showed lymph node involvements. However, the precise mechanism for the metastasis is still not fully understood. This study was to analyze the potential molecular mechanism for lung cancer metastasis. In the current study, proteomics analysis by two-dimensional electrophoresis (2-DE) was performed first to identify the differentially expressed protein between the higher metastasis lung adenocarcinoma cell line Anip973 and the lower metastasis lung adenocarcinoma cell line AGZY83-a. We confirmed the result by RT-PCR, immunoblotting and immunocytochemistry analyses in these two cell lines. Then we examined the expression of the differentially expressed protein in tumor tissues of NSCLC patients by immunoblotting and immunohistochemistry analyses. Using 2-DE analysis, we have identified DJ-1 was expressed higher in the higher metastasis Anip973 compared to the parental cell line AGZY83-a, that was confirmed by RT-PCR, immunoblotting and immunocytochemistry analyses. In NSCLC patients’ tumor tissues study, immunoblotting data showed that, DJ-1 expression level was significantly higher in 72.2% (13/18) of NSCLC tissue samples compared to that in paired normal lung tissues (
P
= 0.044). Immunohistochemistry analysis demonstrated increased DJ-1 expression in 85 NSCLC tumor tissue samples compared with 7 normal lung tissue samples (
P
= 0.044). DJ-1 expression was also found to be significantly correlated with cancer lymphatic metastasis (
P
= 0.039). DJ-1 might contribute to the metastasis of NSCLC. |
| doi_str_mv | 10.1007/s11033-011-1024-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_919954121</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>919954121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-47a54db018bda43e4602c21a773f9c8426660997ccc516b628dc2bc78833bd153</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rr6A7xI8eIpmknSpDmJrN8seNFzSNN06dKPNWkP--9N6aogCGFymGfeGR6EzoFcAyHyJgAQxjABwEAox_IAzSGVDHMls0M0J4wA5lkKM3QSwoYQwkGmx2hGQUiiBJuj2_tXDEljdont2t5X-dC7pO-SxvUmxFeFpCuTtmtxaExdJ9bFUg_tOrGmtc6foqPS1MGd7f8F-nh8eF8-49Xb08vyboUtZ6LHXJqUFzmBLC8MZ44LQi0FIyUrlc04FUIQpaS1NgWRC5oVluZWZhljeQEpW6CrKXfru8_BhV43VRiPMa3rhqAVKJVyoBDJyz_kpht8G48bIZFFSEUIJsj6LgTvSr31VWP8TgPRo1s9udXRrR7dahlnLvbBQ9644mfiW2YE6ASE2GrXzv9u_j_1Cw3egTw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>919684129</pqid></control><display><type>article</type><title>DJ-1 may contribute to metastasis of non-small cell lung cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bai, Jing ; Guo, Changlong ; Sun, Wenjing ; Li, Ming ; Meng, Xiangning ; Yu, Yang ; Jin, Yan ; Tong, Dandan ; Geng, Jingshu ; Huang, Qi ; Qi, Jiping ; Fu, Songbin</creator><creatorcontrib>Bai, Jing ; Guo, Changlong ; Sun, Wenjing ; Li, Ming ; Meng, Xiangning ; Yu, Yang ; Jin, Yan ; Tong, Dandan ; Geng, Jingshu ; Huang, Qi ; Qi, Jiping ; Fu, Songbin</creatorcontrib><description>Lung cancer is a leading cause of cancer-related death, about 40% human non-small cell lung cancer (NSCLC) patients showed lymph node involvements. However, the precise mechanism for the metastasis is still not fully understood. This study was to analyze the potential molecular mechanism for lung cancer metastasis. In the current study, proteomics analysis by two-dimensional electrophoresis (2-DE) was performed first to identify the differentially expressed protein between the higher metastasis lung adenocarcinoma cell line Anip973 and the lower metastasis lung adenocarcinoma cell line AGZY83-a. We confirmed the result by RT-PCR, immunoblotting and immunocytochemistry analyses in these two cell lines. Then we examined the expression of the differentially expressed protein in tumor tissues of NSCLC patients by immunoblotting and immunohistochemistry analyses. Using 2-DE analysis, we have identified DJ-1 was expressed higher in the higher metastasis Anip973 compared to the parental cell line AGZY83-a, that was confirmed by RT-PCR, immunoblotting and immunocytochemistry analyses. In NSCLC patients’ tumor tissues study, immunoblotting data showed that, DJ-1 expression level was significantly higher in 72.2% (13/18) of NSCLC tissue samples compared to that in paired normal lung tissues (
P
= 0.044). Immunohistochemistry analysis demonstrated increased DJ-1 expression in 85 NSCLC tumor tissue samples compared with 7 normal lung tissue samples (
P
= 0.044). DJ-1 expression was also found to be significantly correlated with cancer lymphatic metastasis (
P
= 0.039). DJ-1 might contribute to the metastasis of NSCLC.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1024-7</identifier><identifier>PMID: 21670963</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell Line, Tumor ; DNA Primers - genetics ; Electrophoresis, Gel, Two-Dimensional ; Genetic Association Studies ; Histology ; Humans ; Immunoblotting ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Life Sciences ; Lung cancer ; Lymphatic Metastasis - genetics ; Lymphatic Metastasis - physiopathology ; Metastasis ; Morphology ; Oncogene Proteins - genetics ; Oncogene Proteins - metabolism ; Protein Deglycase DJ-1 ; Reverse Transcriptase Polymerase Chain Reaction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><ispartof>Molecular biology reports, 2012-03, Vol.39 (3), p.2697-2703</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-47a54db018bda43e4602c21a773f9c8426660997ccc516b628dc2bc78833bd153</citedby><cites>FETCH-LOGICAL-c436t-47a54db018bda43e4602c21a773f9c8426660997ccc516b628dc2bc78833bd153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1024-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1024-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21670963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Jing</creatorcontrib><creatorcontrib>Guo, Changlong</creatorcontrib><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Meng, Xiangning</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Tong, Dandan</creatorcontrib><creatorcontrib>Geng, Jingshu</creatorcontrib><creatorcontrib>Huang, Qi</creatorcontrib><creatorcontrib>Qi, Jiping</creatorcontrib><creatorcontrib>Fu, Songbin</creatorcontrib><title>DJ-1 may contribute to metastasis of non-small cell lung cancer</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Lung cancer is a leading cause of cancer-related death, about 40% human non-small cell lung cancer (NSCLC) patients showed lymph node involvements. However, the precise mechanism for the metastasis is still not fully understood. This study was to analyze the potential molecular mechanism for lung cancer metastasis. In the current study, proteomics analysis by two-dimensional electrophoresis (2-DE) was performed first to identify the differentially expressed protein between the higher metastasis lung adenocarcinoma cell line Anip973 and the lower metastasis lung adenocarcinoma cell line AGZY83-a. We confirmed the result by RT-PCR, immunoblotting and immunocytochemistry analyses in these two cell lines. Then we examined the expression of the differentially expressed protein in tumor tissues of NSCLC patients by immunoblotting and immunohistochemistry analyses. Using 2-DE analysis, we have identified DJ-1 was expressed higher in the higher metastasis Anip973 compared to the parental cell line AGZY83-a, that was confirmed by RT-PCR, immunoblotting and immunocytochemistry analyses. In NSCLC patients’ tumor tissues study, immunoblotting data showed that, DJ-1 expression level was significantly higher in 72.2% (13/18) of NSCLC tissue samples compared to that in paired normal lung tissues (
P
= 0.044). Immunohistochemistry analysis demonstrated increased DJ-1 expression in 85 NSCLC tumor tissue samples compared with 7 normal lung tissue samples (
P
= 0.044). DJ-1 expression was also found to be significantly correlated with cancer lymphatic metastasis (
P
= 0.039). DJ-1 might contribute to the metastasis of NSCLC.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell Line, Tumor</subject><subject>DNA Primers - genetics</subject><subject>Electrophoresis, Gel, Two-Dimensional</subject><subject>Genetic Association Studies</subject><subject>Histology</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Life Sciences</subject><subject>Lung cancer</subject><subject>Lymphatic Metastasis - genetics</subject><subject>Lymphatic Metastasis - physiopathology</subject><subject>Metastasis</subject><subject>Morphology</subject><subject>Oncogene Proteins - genetics</subject><subject>Oncogene Proteins - metabolism</subject><subject>Protein Deglycase DJ-1</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xI8eIpmknSpDmJrN8seNFzSNN06dKPNWkP--9N6aogCGFymGfeGR6EzoFcAyHyJgAQxjABwEAox_IAzSGVDHMls0M0J4wA5lkKM3QSwoYQwkGmx2hGQUiiBJuj2_tXDEljdont2t5X-dC7pO-SxvUmxFeFpCuTtmtxaExdJ9bFUg_tOrGmtc6foqPS1MGd7f8F-nh8eF8-49Xb08vyboUtZ6LHXJqUFzmBLC8MZ44LQi0FIyUrlc04FUIQpaS1NgWRC5oVluZWZhljeQEpW6CrKXfru8_BhV43VRiPMa3rhqAVKJVyoBDJyz_kpht8G48bIZFFSEUIJsj6LgTvSr31VWP8TgPRo1s9udXRrR7dahlnLvbBQ9644mfiW2YE6ASE2GrXzv9u_j_1Cw3egTw</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Bai, Jing</creator><creator>Guo, Changlong</creator><creator>Sun, Wenjing</creator><creator>Li, Ming</creator><creator>Meng, Xiangning</creator><creator>Yu, Yang</creator><creator>Jin, Yan</creator><creator>Tong, Dandan</creator><creator>Geng, Jingshu</creator><creator>Huang, Qi</creator><creator>Qi, Jiping</creator><creator>Fu, Songbin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>DJ-1 may contribute to metastasis of non-small cell lung cancer</title><author>Bai, Jing ; Guo, Changlong ; Sun, Wenjing ; Li, Ming ; Meng, Xiangning ; Yu, Yang ; Jin, Yan ; Tong, Dandan ; Geng, Jingshu ; Huang, Qi ; Qi, Jiping ; Fu, Songbin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-47a54db018bda43e4602c21a773f9c8426660997ccc516b628dc2bc78833bd153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell Line, Tumor</topic><topic>DNA Primers - genetics</topic><topic>Electrophoresis, Gel, Two-Dimensional</topic><topic>Genetic Association Studies</topic><topic>Histology</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Life Sciences</topic><topic>Lung cancer</topic><topic>Lymphatic Metastasis - genetics</topic><topic>Lymphatic Metastasis - physiopathology</topic><topic>Metastasis</topic><topic>Morphology</topic><topic>Oncogene Proteins - genetics</topic><topic>Oncogene Proteins - metabolism</topic><topic>Protein Deglycase DJ-1</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Jing</creatorcontrib><creatorcontrib>Guo, Changlong</creatorcontrib><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Meng, Xiangning</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Tong, Dandan</creatorcontrib><creatorcontrib>Geng, Jingshu</creatorcontrib><creatorcontrib>Huang, Qi</creatorcontrib><creatorcontrib>Qi, Jiping</creatorcontrib><creatorcontrib>Fu, Songbin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Jing</au><au>Guo, Changlong</au><au>Sun, Wenjing</au><au>Li, Ming</au><au>Meng, Xiangning</au><au>Yu, Yang</au><au>Jin, Yan</au><au>Tong, Dandan</au><au>Geng, Jingshu</au><au>Huang, Qi</au><au>Qi, Jiping</au><au>Fu, Songbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DJ-1 may contribute to metastasis of non-small cell lung cancer</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>39</volume><issue>3</issue><spage>2697</spage><epage>2703</epage><pages>2697-2703</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Lung cancer is a leading cause of cancer-related death, about 40% human non-small cell lung cancer (NSCLC) patients showed lymph node involvements. However, the precise mechanism for the metastasis is still not fully understood. This study was to analyze the potential molecular mechanism for lung cancer metastasis. In the current study, proteomics analysis by two-dimensional electrophoresis (2-DE) was performed first to identify the differentially expressed protein between the higher metastasis lung adenocarcinoma cell line Anip973 and the lower metastasis lung adenocarcinoma cell line AGZY83-a. We confirmed the result by RT-PCR, immunoblotting and immunocytochemistry analyses in these two cell lines. Then we examined the expression of the differentially expressed protein in tumor tissues of NSCLC patients by immunoblotting and immunohistochemistry analyses. Using 2-DE analysis, we have identified DJ-1 was expressed higher in the higher metastasis Anip973 compared to the parental cell line AGZY83-a, that was confirmed by RT-PCR, immunoblotting and immunocytochemistry analyses. In NSCLC patients’ tumor tissues study, immunoblotting data showed that, DJ-1 expression level was significantly higher in 72.2% (13/18) of NSCLC tissue samples compared to that in paired normal lung tissues (
P
= 0.044). Immunohistochemistry analysis demonstrated increased DJ-1 expression in 85 NSCLC tumor tissue samples compared with 7 normal lung tissue samples (
P
= 0.044). DJ-1 expression was also found to be significantly correlated with cancer lymphatic metastasis (
P
= 0.039). DJ-1 might contribute to the metastasis of NSCLC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21670963</pmid><doi>10.1007/s11033-011-1024-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor DNA Primers - genetics Electrophoresis, Gel, Two-Dimensional Genetic Association Studies Histology Humans Immunoblotting Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Lung cancer Lymphatic Metastasis - genetics Lymphatic Metastasis - physiopathology Metastasis Morphology Oncogene Proteins - genetics Oncogene Proteins - metabolism Protein Deglycase DJ-1 Reverse Transcriptase Polymerase Chain Reaction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| title | DJ-1 may contribute to metastasis of non-small cell lung cancer |
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