Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India

Background Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatme...

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Veröffentlicht in:Surgical endoscopy 2012-03, Vol.26 (3), p.688-692
Hauptverfasser: Praveen Raj, P., Kumaravel, R., Chandramaliteeswaran, C., Vaithiswaran, V., Palanivelu, C.
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container_end_page 692
container_issue 3
container_start_page 688
container_title Surgical endoscopy
container_volume 26
creator Praveen Raj, P.
Kumaravel, R.
Chandramaliteeswaran, C.
Vaithiswaran, V.
Palanivelu, C.
description Background Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients. Methods At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed. Results The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality. Conclusion Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.
doi_str_mv 10.1007/s00464-011-1938-0
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Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients. Methods At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed. Results The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality. Conclusion Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-011-1938-0</identifier><identifier>PMID: 21993937</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Anastomosis, Surgical - methods ; Biological and medical sciences ; Body Mass Index ; Cholesterol - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Digestive system. Abdomen ; Duodenum - surgery ; Endoscopy ; Female ; Gastrectomy - methods ; Gastric Bypass - methods ; Gastroenterology ; Gastrointestinal surgery ; General aspects ; Glycated Hemoglobin A - metabolism ; Gynecology ; Hepatology ; Humans ; Hypotheses ; Investigative techniques, diagnostic techniques (general aspects) ; Jejunum - surgery ; Laparoscopy ; Laparoscopy - methods ; Length of Stay ; Male ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; Proctology ; Prospective Studies ; Small intestine ; Stomach, duodenum, intestine, rectum, anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients. Methods At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed. Results The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality. Conclusion Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Anastomosis, Surgical - methods</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cholesterol - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Digestive system. Abdomen</subject><subject>Duodenum - surgery</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastric Bypass - methods</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>General aspects</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Jejunum - surgery</subject><subject>Laparoscopy</subject><subject>Laparoscopy - methods</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>Proctology</subject><subject>Prospective Studies</subject><subject>Small intestine</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Surveillance</subject><subject>Treatment Outcome</subject><subject>Triglycerides - metabolism</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtP3DAUha0KBFPgB3RTWUgVq1A_k5gdQn0gjcSmXVuOc0M9SuLgm1DNv6-nMxSpEqu7uN-5j3MI-cDZNWes-oyMqVIVjPOCG1kX7B1ZcSVFIQSvj8iKGckKURl1St4jbljGDdcn5FRwY6SR1YqktZtciujjFDxtl9jCGDewWUbX02Y7OUT6O8y_KPYAz0AfHc4J_ByH7Q2dEvRhCKNLW5oAl35GGjvqciPilKmQFQgpANIuxYHej21w5-S4cz3CxaGekZ9fv_y4-16sH77d392uC68YmwtVSwYeyrpRUipwrlECgHdeC2Wk0F5IroTsqsYY1nDQytSi1dxVDTClvDwjV_u5-ZqnBXC2Q0APfe9GiAtak03QUmuVycv_yE1cUnbgL1TWpSlZhvge8vk5TNDZKYUhv245s7s47D4Om-OwuzjsTvPxMHhpBmj_KV78z8CnA-DQu75LbvQBXzmtK1OZOnNiz2FujY-QXi98e_sfswKjmA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Praveen Raj, P.</creator><creator>Kumaravel, R.</creator><creator>Chandramaliteeswaran, C.</creator><creator>Vaithiswaran, V.</creator><creator>Palanivelu, C.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India</title><author>Praveen Raj, P. ; Kumaravel, R. ; Chandramaliteeswaran, C. ; Vaithiswaran, V. ; Palanivelu, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-4830ece68b4334eaab42ee1fc5249325c231423f7b990b1e54982d51a7be044c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Anastomosis, Surgical - methods</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cholesterol - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Digestive system. Abdomen</topic><topic>Duodenum - surgery</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastric Bypass - methods</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>General aspects</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Jejunum - surgery</topic><topic>Laparoscopy</topic><topic>Laparoscopy - methods</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>Proctology</topic><topic>Prospective Studies</topic><topic>Small intestine</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Surveillance</topic><topic>Treatment Outcome</topic><topic>Triglycerides - metabolism</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Praveen Raj, P.</creatorcontrib><creatorcontrib>Kumaravel, R.</creatorcontrib><creatorcontrib>Chandramaliteeswaran, C.</creatorcontrib><creatorcontrib>Vaithiswaran, V.</creatorcontrib><creatorcontrib>Palanivelu, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Praveen Raj, P.</au><au>Kumaravel, R.</au><au>Chandramaliteeswaran, C.</au><au>Vaithiswaran, V.</au><au>Palanivelu, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>26</volume><issue>3</issue><spage>688</spage><epage>692</epage><pages>688-692</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Background Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients. Methods At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed. Results The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality. Conclusion Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21993937</pmid><doi>10.1007/s00464-011-1938-0</doi><tpages>5</tpages></addata></record>
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subjects Abdominal Surgery
Adult
Anastomosis, Surgical - methods
Biological and medical sciences
Body Mass Index
Cholesterol - metabolism
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Digestive system. Abdomen
Duodenum - surgery
Endoscopy
Female
Gastrectomy - methods
Gastric Bypass - methods
Gastroenterology
Gastrointestinal surgery
General aspects
Glycated Hemoglobin A - metabolism
Gynecology
Hepatology
Humans
Hypotheses
Investigative techniques, diagnostic techniques (general aspects)
Jejunum - surgery
Laparoscopy
Laparoscopy - methods
Length of Stay
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolism
Middle Aged
Obesity
Obesity, Morbid - blood
Obesity, Morbid - complications
Obesity, Morbid - surgery
Proctology
Prospective Studies
Small intestine
Stomach, duodenum, intestine, rectum, anus
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Surveillance
Treatment Outcome
Triglycerides - metabolism
Weight control
Weight Loss
title Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India
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