Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India
Background Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatme...
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description | Background
Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients.
Methods
At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed.
Results
The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality.
Conclusion
Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed. |
doi_str_mv | 10.1007/s00464-011-1938-0 |
format | Article |
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Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients.
Methods
At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed.
Results
The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality.
Conclusion
Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-011-1938-0</identifier><identifier>PMID: 21993937</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Anastomosis, Surgical - methods ; Biological and medical sciences ; Body Mass Index ; Cholesterol - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Digestive system. Abdomen ; Duodenum - surgery ; Endoscopy ; Female ; Gastrectomy - methods ; Gastric Bypass - methods ; Gastroenterology ; Gastrointestinal surgery ; General aspects ; Glycated Hemoglobin A - metabolism ; Gynecology ; Hepatology ; Humans ; Hypotheses ; Investigative techniques, diagnostic techniques (general aspects) ; Jejunum - surgery ; Laparoscopy ; Laparoscopy - methods ; Length of Stay ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; Proctology ; Prospective Studies ; Small intestine ; Stomach, duodenum, intestine, rectum, anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Surveillance ; Treatment Outcome ; Triglycerides - metabolism ; Weight control ; Weight Loss</subject><ispartof>Surgical endoscopy, 2012-03, Vol.26 (3), p.688-692</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-4830ece68b4334eaab42ee1fc5249325c231423f7b990b1e54982d51a7be044c3</citedby><cites>FETCH-LOGICAL-c400t-4830ece68b4334eaab42ee1fc5249325c231423f7b990b1e54982d51a7be044c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-011-1938-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-011-1938-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25579798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21993937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Praveen Raj, P.</creatorcontrib><creatorcontrib>Kumaravel, R.</creatorcontrib><creatorcontrib>Chandramaliteeswaran, C.</creatorcontrib><creatorcontrib>Vaithiswaran, V.</creatorcontrib><creatorcontrib>Palanivelu, C.</creatorcontrib><title>Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background
Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients.
Methods
At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed.
Results
The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality.
Conclusion
Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Anastomosis, Surgical - methods</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cholesterol - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Digestive system. Abdomen</subject><subject>Duodenum - surgery</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastric Bypass - methods</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>General aspects</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Jejunum - surgery</subject><subject>Laparoscopy</subject><subject>Laparoscopy - methods</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>Proctology</subject><subject>Prospective Studies</subject><subject>Small intestine</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Surveillance</subject><subject>Treatment Outcome</subject><subject>Triglycerides - metabolism</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtP3DAUha0KBFPgB3RTWUgVq1A_k5gdQn0gjcSmXVuOc0M9SuLgm1DNv6-nMxSpEqu7uN-5j3MI-cDZNWes-oyMqVIVjPOCG1kX7B1ZcSVFIQSvj8iKGckKURl1St4jbljGDdcn5FRwY6SR1YqktZtciujjFDxtl9jCGDewWUbX02Y7OUT6O8y_KPYAz0AfHc4J_ByH7Q2dEvRhCKNLW5oAl35GGjvqciPilKmQFQgpANIuxYHej21w5-S4cz3CxaGekZ9fv_y4-16sH77d392uC68YmwtVSwYeyrpRUipwrlECgHdeC2Wk0F5IroTsqsYY1nDQytSi1dxVDTClvDwjV_u5-ZqnBXC2Q0APfe9GiAtak03QUmuVycv_yE1cUnbgL1TWpSlZhvge8vk5TNDZKYUhv245s7s47D4Om-OwuzjsTvPxMHhpBmj_KV78z8CnA-DQu75LbvQBXzmtK1OZOnNiz2FujY-QXi98e_sfswKjmA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Praveen Raj, P.</creator><creator>Kumaravel, R.</creator><creator>Chandramaliteeswaran, C.</creator><creator>Vaithiswaran, V.</creator><creator>Palanivelu, C.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India</title><author>Praveen Raj, P. ; Kumaravel, R. ; Chandramaliteeswaran, C. ; Vaithiswaran, V. ; Palanivelu, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-4830ece68b4334eaab42ee1fc5249325c231423f7b990b1e54982d51a7be044c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Anastomosis, Surgical - methods</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cholesterol - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Digestive system. Abdomen</topic><topic>Duodenum - surgery</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastric Bypass - methods</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>General aspects</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Jejunum - surgery</topic><topic>Laparoscopy</topic><topic>Laparoscopy - methods</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>Proctology</topic><topic>Prospective Studies</topic><topic>Small intestine</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Surveillance</topic><topic>Treatment Outcome</topic><topic>Triglycerides - metabolism</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Praveen Raj, P.</creatorcontrib><creatorcontrib>Kumaravel, R.</creatorcontrib><creatorcontrib>Chandramaliteeswaran, C.</creatorcontrib><creatorcontrib>Vaithiswaran, V.</creatorcontrib><creatorcontrib>Palanivelu, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Praveen Raj, P.</au><au>Kumaravel, R.</au><au>Chandramaliteeswaran, C.</au><au>Vaithiswaran, V.</au><au>Palanivelu, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>26</volume><issue>3</issue><spage>688</spage><epage>692</epage><pages>688-692</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Background
Bariatric surgeries are now redefined as metabolic surgeries given the excellent resolution of metabolic derangements accompanying obesity. Duodenojejunal bypass (DJB) is a novel metabolic surgery based on foregut hypothesis. Reports describe DJB as a stand-alone procedure for the treatment of diabetes in nonobese subjects. For obese subjects, DJB is combined with sleeve gastrectomy. This combination of DJB and sleeve gastrectomy is proposed as an ideal alternative to Roux-en-Y gastric bypass (RYGB) with these advantages: (1) easy postoperative endoscopic surveillance, (2) preservation of the pyloric mechanism, which prevents dumping syndrome, and (3) reduced alimentary limb tension. This study aimed to analyze the short-term outcomes of laparoscopic DJB with sleeve gastrectomy for morbidly obese patients.
Methods
At our institution, 38 patients who underwent laparoscopic DJB with sleeve gastrectomy were followed up. The inclusion criteria for the study were according to the Asian Pacific Bariatric Surgery Society guidelines. Sleeve gastrectomy was performed over a 36-Fr bougie, with the first part of the duodenum mobilized and transected. The jejunum was divided 50 cm distal to duodenojejunal flexure. A 75- to 150-cm alimentary limb was fashioned and brought in a retrocolic manner. End-to-end hand-sewn duodenojejunostomy was performed. Intestinal continuity was restored with a stapled jejunojejunostomy, and mesenteric rents were closed.
Results
The study population consisted of 38 patients (15 men and 23 women) ranging in age from 31 to 48 years. During a mean follow-up period of 17 months, the excess body weight loss was 72%, with a 92% resolution of diabetes. One patient presented with internal herniation through the retrocolic window 1 month after the operation and was managed surgically without any complication. No other minor or major complications occurred, and there was no mortality.
Conclusion
Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. Long-term follow-up studies are needed.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21993937</pmid><doi>10.1007/s00464-011-1938-0</doi><tpages>5</tpages></addata></record> |
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subjects | Abdominal Surgery Adult Anastomosis, Surgical - methods Biological and medical sciences Body Mass Index Cholesterol - metabolism Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Digestive system. Abdomen Duodenum - surgery Endoscopy Female Gastrectomy - methods Gastric Bypass - methods Gastroenterology Gastrointestinal surgery General aspects Glycated Hemoglobin A - metabolism Gynecology Hepatology Humans Hypotheses Investigative techniques, diagnostic techniques (general aspects) Jejunum - surgery Laparoscopy Laparoscopy - methods Length of Stay Male Medical sciences Medicine Medicine & Public Health Metabolism Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - surgery Proctology Prospective Studies Small intestine Stomach, duodenum, intestine, rectum, anus Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Surveillance Treatment Outcome Triglycerides - metabolism Weight control Weight Loss |
title | Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India |
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