IN VITRO ACTIVITY OF COLISTIN OR SULBACTAM IN COMBINATION WITH FOSFOMYCIN OR IMIPENEM AGAINST CLINICAL ISOLATES OF CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII PRODUCING OXA-23 CARBAPENEMASES
This study investigated the in vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against eight strains of carbapenem-resistant A. baumannii (CRAB). The eight CRAB clinical isolates were collected from hospitalized patients admitted to Songklanagarind Hospital in sout...
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| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 2011-07, Vol.42 (4), p.890-900 |
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| creator | SANTIMALEEWORAGUN, Wichai WONGPOOWARAK, Payom CHAYAKUL, Pantip PATTHARACHAYAKUL, Sutthiporn TANSAKUL, Pimpimon GAREY, Kevin W |
| description | This study investigated the in vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against eight strains of carbapenem-resistant A. baumannii (CRAB). The eight CRAB clinical isolates were collected from hospitalized patients admitted to Songklanagarind Hospital in southern Thailand during January-December 2008. The isolates were divided into 4 different patterns of clonal relationships using the Repetitive Extragenic Palindromic-Polymerase Chain Reaction method (REP-PCR). The in vitro activity of combination antibacterial agents against theses isolates were determined by chequerboard and time-kill methods. All isolates producing OXA-23 carbapenemases were universally susceptible to colistin but intermittently susceptible to other antimicrobial agents. A chequerboard assay showed the synergistic effects of sulbactam plus fosfomycin and colistin plus fosfomycin in 75% and 12.5% of isolates, respectively. Sulbactam at a concentration of 1 x MIC plus fosfomycin at 1 x MIC or at 1/4 x MIC showed synergism in 75% and 37.5% of clinical isolates, respectively. Bactericidal activity was observed for up to 12 hours of incubation. There was no synergism between colistin and sulbactam, sulbactam and imipenem, and colistin and imipenem, against the tested isolates. Combined use of sulbactam and fosfomycin may provide an alternative therapeutic option for CRAB infections. |
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The eight CRAB clinical isolates were collected from hospitalized patients admitted to Songklanagarind Hospital in southern Thailand during January-December 2008. The isolates were divided into 4 different patterns of clonal relationships using the Repetitive Extragenic Palindromic-Polymerase Chain Reaction method (REP-PCR). The in vitro activity of combination antibacterial agents against theses isolates were determined by chequerboard and time-kill methods. All isolates producing OXA-23 carbapenemases were universally susceptible to colistin but intermittently susceptible to other antimicrobial agents. A chequerboard assay showed the synergistic effects of sulbactam plus fosfomycin and colistin plus fosfomycin in 75% and 12.5% of isolates, respectively. Sulbactam at a concentration of 1 x MIC plus fosfomycin at 1 x MIC or at 1/4 x MIC showed synergism in 75% and 37.5% of clinical isolates, respectively. Bactericidal activity was observed for up to 12 hours of incubation. There was no synergism between colistin and sulbactam, sulbactam and imipenem, and colistin and imipenem, against the tested isolates. Combined use of sulbactam and fosfomycin may provide an alternative therapeutic option for CRAB infections.</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 22299471</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: SEAMO, Regional Tropical Medicine and Public Health Network</publisher><subject>Acinetobacter baumannii ; Acinetobacter baumannii - drug effects ; Acinetobacter baumannii - enzymology ; Acinetobacter baumannii - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial agents ; Bacterial Proteins - metabolism ; beta-Lactam Resistance ; beta-Lactamases - metabolism ; Biological and medical sciences ; Carbapenems - pharmacology ; Colistin - pharmacology ; Decapoda ; Drug Therapy, Combination ; Fosfomycin - pharmacology ; General aspects ; Humans ; Imipenem - pharmacology ; In Vitro Techniques ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Synergism ; Synergistic effect ; Thailand ; Time Factors</subject><ispartof>Southeast Asian journal of tropical medicine and public health, 2011-07, Vol.42 (4), p.890-900</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Central Coordinating Board, SEAMEO-TROPMED Project Jul 2011</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24388047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22299471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANTIMALEEWORAGUN, Wichai</creatorcontrib><creatorcontrib>WONGPOOWARAK, Payom</creatorcontrib><creatorcontrib>CHAYAKUL, Pantip</creatorcontrib><creatorcontrib>PATTHARACHAYAKUL, Sutthiporn</creatorcontrib><creatorcontrib>TANSAKUL, Pimpimon</creatorcontrib><creatorcontrib>GAREY, Kevin W</creatorcontrib><title>IN VITRO ACTIVITY OF COLISTIN OR SULBACTAM IN COMBINATION WITH FOSFOMYCIN OR IMIPENEM AGAINST CLINICAL ISOLATES OF CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII PRODUCING OXA-23 CARBAPENEMASES</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>This study investigated the in vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against eight strains of carbapenem-resistant A. baumannii (CRAB). The eight CRAB clinical isolates were collected from hospitalized patients admitted to Songklanagarind Hospital in southern Thailand during January-December 2008. The isolates were divided into 4 different patterns of clonal relationships using the Repetitive Extragenic Palindromic-Polymerase Chain Reaction method (REP-PCR). The in vitro activity of combination antibacterial agents against theses isolates were determined by chequerboard and time-kill methods. All isolates producing OXA-23 carbapenemases were universally susceptible to colistin but intermittently susceptible to other antimicrobial agents. A chequerboard assay showed the synergistic effects of sulbactam plus fosfomycin and colistin plus fosfomycin in 75% and 12.5% of isolates, respectively. Sulbactam at a concentration of 1 x MIC plus fosfomycin at 1 x MIC or at 1/4 x MIC showed synergism in 75% and 37.5% of clinical isolates, respectively. Bactericidal activity was observed for up to 12 hours of incubation. There was no synergism between colistin and sulbactam, sulbactam and imipenem, and colistin and imipenem, against the tested isolates. Combined use of sulbactam and fosfomycin may provide an alternative therapeutic option for CRAB infections.</description><subject>Acinetobacter baumannii</subject><subject>Acinetobacter baumannii - drug effects</subject><subject>Acinetobacter baumannii - enzymology</subject><subject>Acinetobacter baumannii - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial agents</subject><subject>Bacterial Proteins - metabolism</subject><subject>beta-Lactam Resistance</subject><subject>beta-Lactamases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbapenems - pharmacology</subject><subject>Colistin - pharmacology</subject><subject>Decapoda</subject><subject>Drug Therapy, Combination</subject><subject>Fosfomycin - pharmacology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Imipenem - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Synergism</subject><subject>Synergistic effect</subject><subject>Thailand</subject><subject>Time Factors</subject><issn>0125-1562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90U1P5CAYB_Ae1qwv61fYkE02emnCS1vgyNTOSNKCKYy7nhqmpcmYebN1Dn46v5qoYzR72AMB8vx4_hC-RScQ4TRGaYaPo9NxvIcwgYiz79ExxpjzhKKT6FkqcCttrYHIrQyrO6CnINelNDaUdA3MvJyEmqhA2Oe6mkglrNQK_JH2Gky1merqLn-3spI3hSoqIGZCKmNBXkolc1ECaXQpbGHeuot6It5cXBcmBAllQ7xUhdWvUUUNJmJeCaWkBDe1vpqH2gzovyLG5MtpYQrzIzrq3Wr054f5LJpPC5tfx6WevQbHOwLhY9zxFKc9QTjhWZZSwju-aFOUMkZoz_sWU8Z7RJzPsEepJ552i6xzLYMkIS6Ms-jive9u2D7s_fjYrJdj61crt_Hb_dhwxEMEhzjIy_9KhChiNAkXCfTXP_R-ux824R0NYwkmGYUkoJ8HtF-sfdfshuXaDU_Nxx8G8PsA3Ni6VT-4TbscP11CGIMJJS_tQJNs</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>SANTIMALEEWORAGUN, Wichai</creator><creator>WONGPOOWARAK, Payom</creator><creator>CHAYAKUL, Pantip</creator><creator>PATTHARACHAYAKUL, Sutthiporn</creator><creator>TANSAKUL, Pimpimon</creator><creator>GAREY, Kevin W</creator><general>SEAMO, Regional Tropical Medicine and Public Health Network</general><general>Central Coordinating Board, SEAMEO-TROPMED Project</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>IN VITRO ACTIVITY OF COLISTIN OR SULBACTAM IN COMBINATION WITH FOSFOMYCIN OR IMIPENEM AGAINST CLINICAL ISOLATES OF CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII PRODUCING OXA-23 CARBAPENEMASES</title><author>SANTIMALEEWORAGUN, Wichai ; WONGPOOWARAK, Payom ; CHAYAKUL, Pantip ; PATTHARACHAYAKUL, Sutthiporn ; TANSAKUL, Pimpimon ; GAREY, Kevin W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p300t-d9525f31249665739d9bc5158837f9fc2789f13ae62e15e3e7db6dac80343a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acinetobacter baumannii</topic><topic>Acinetobacter baumannii - drug effects</topic><topic>Acinetobacter baumannii - enzymology</topic><topic>Acinetobacter baumannii - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobial agents</topic><topic>Bacterial Proteins - metabolism</topic><topic>beta-Lactam Resistance</topic><topic>beta-Lactamases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbapenems - pharmacology</topic><topic>Colistin - pharmacology</topic><topic>Decapoda</topic><topic>Drug Therapy, Combination</topic><topic>Fosfomycin - pharmacology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Imipenem - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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The eight CRAB clinical isolates were collected from hospitalized patients admitted to Songklanagarind Hospital in southern Thailand during January-December 2008. The isolates were divided into 4 different patterns of clonal relationships using the Repetitive Extragenic Palindromic-Polymerase Chain Reaction method (REP-PCR). The in vitro activity of combination antibacterial agents against theses isolates were determined by chequerboard and time-kill methods. All isolates producing OXA-23 carbapenemases were universally susceptible to colistin but intermittently susceptible to other antimicrobial agents. A chequerboard assay showed the synergistic effects of sulbactam plus fosfomycin and colistin plus fosfomycin in 75% and 12.5% of isolates, respectively. Sulbactam at a concentration of 1 x MIC plus fosfomycin at 1 x MIC or at 1/4 x MIC showed synergism in 75% and 37.5% of clinical isolates, respectively. Bactericidal activity was observed for up to 12 hours of incubation. There was no synergism between colistin and sulbactam, sulbactam and imipenem, and colistin and imipenem, against the tested isolates. Combined use of sulbactam and fosfomycin may provide an alternative therapeutic option for CRAB infections.</abstract><cop>Bangkok</cop><pub>SEAMO, Regional Tropical Medicine and Public Health Network</pub><pmid>22299471</pmid><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0125-1562 |
| ispartof | Southeast Asian journal of tropical medicine and public health, 2011-07, Vol.42 (4), p.890-900 |
| issn | 0125-1562 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - enzymology Acinetobacter baumannii - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Bacterial Proteins - metabolism beta-Lactam Resistance beta-Lactamases - metabolism Biological and medical sciences Carbapenems - pharmacology Colistin - pharmacology Decapoda Drug Therapy, Combination Fosfomycin - pharmacology General aspects Humans Imipenem - pharmacology In Vitro Techniques Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Polymerase Chain Reaction Synergism Synergistic effect Thailand Time Factors |
| title | IN VITRO ACTIVITY OF COLISTIN OR SULBACTAM IN COMBINATION WITH FOSFOMYCIN OR IMIPENEM AGAINST CLINICAL ISOLATES OF CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII PRODUCING OXA-23 CARBAPENEMASES |
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