C9-R95X polymorphism in patients with neovascular age-related macular degeneration

A non-sense mutation at codon 95 in the gene encoding complement factor C9 (C9-R95X) is found most frequently among Japanese. The authors investigated the association between C9-R95X and Japanese patients with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2012-01, Vol.53 (1), p.508-512
Hauptverfasser:	Nishiguchi, Koji M, Yasuma, Tetsuhiro R, Tomida, Daisuke, Nakamura, Makoto, Ishikawa, Kohei, Kikuchi, Masato, Ohmi, Yuhsuke, Niwa, Toshimitsu, Hamajima, Nobuyuki, Furukawa, Koichi, Terasaki, Hiroko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Complement C9 - genetics Complement C9 - metabolism Disease Models, Animal DNA - genetics Female Fluorescein Angiography Fundus Oculi Genotype Humans Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology Male Mice Mice, Inbred C57BL Polymerase Chain Reaction Polymorphism, Genetic Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology
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